Results 61 to 70 of about 15,754,334 (318)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Observation of a new boson at a mass of 125 GeV with the CMS experiment at the LHC

open access: yes, 2012
Results are presented from searches for the standard model Higgs boson in proton-proton collisions at sqrt(s)=7 and 8 TeV in the CMS experiment at the LHC, using data samples corresponding to integrated luminosities of up to 5.1 inverse femtobarns at 7 ...
S. Chatrchyan   +499 more
semanticscholar   +1 more source

Comprehensive genomic characterization of squamous cell lung cancers

open access: yesNature, 2012
Lung squamous cell carcinoma is a common type of lung cancer, causing approximately 400,000 deaths per year worldwide. Genomic alterations in squamous cell lung cancers have not been comprehensively characterized, and no molecularly targeted agents have ...
P. Hammerman   +332 more
semanticscholar   +1 more source

A new dynamical approach of Emden-Fowler equations and systems [PDF]

open access: yes, 2010
We give a new approach on general systems of the form \[(G){[c]{c}% -\Delta_{p}u=\operatorname{div}(|\nabla u| ^{p-2}\nabla u)=\epsilon_{1}|x| ^{a}u^{s}v^{\delta}, -\Delta_{q}v=\operatorname{div}(|\nabla v|^{q-2}\nabla u)=\epsilon_{2}|x|^{b}u^{\mu}v^{m},\
Bidaut-Véron, Marie-Françoise   +1 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Multimessenger observations of a flaring blazar coincident with high-energy neutrino IceCube-170922A [PDF]

open access: yesScience, 2018
Neutrino emission from a flaring blazar Neutrinos interact only very weakly with matter, but giant detectors have succeeded in detecting small numbers of astrophysical neutrinos.
M. Aartsen   +499 more
semanticscholar   +1 more source

Open-charm tetraquark $$X_c$$ X c and open-bottom tetraquark $$X_b$$ X b

open access: yesEuropean Physical Journal C: Particles and Fields, 2020
Motivated by the LHCb observation of exotic states $$X_{0,1}(2900)$$ X 0 , 1 ( 2900 ) with four open quark flavors in the $$D^- K^+$$ D - K + invariant mass distribution in the decay channel $$B^\pm \rightarrow D^+ D^- K^\pm $$ B ± → D + D - K ± , we ...
Xiao-Gang He, Wei Wang, Ruilin Zhu
doaj   +1 more source

Global bifurcation and constant sign solutions of discrete boundary value problem involving p-Laplacian

open access: yesAdvances in Difference Equations, 2021
We study the unilateral global bifurcation result for the one-dimensional discrete p-Laplacian problem { − Δ [ φ p ( Δ u ( t − 1 ) ) ] = λ a ( t ) φ p ( u ( t ) ) + g ( t , u ( t ) , λ ) , t ∈ [ 1 , T + 1 ] Z , Δ u ( 0 ) = u ( T + 2 ) = 0 , $$ \textstyle\
Fumei Ye
doaj   +1 more source

Boundedness of the extremal solutions in dimension 4 [PDF]

open access: yes, 2012
In this paper we establish the boundedness of the extremal solution u^* in dimension N=4 of the semilinear elliptic equation $-\Delta u=\lambda f(u)$, in a general smooth bounded domain Omega of R^N, with Dirichlet data $u|_{\partial \Omega}=0$, where f ...
Villegas, Salvador
core  

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