Results 121 to 130 of about 5,768 (191)

Inactivation of Ube3a in P19 embryonic carcinoma cells by RNA interference

, 2006
UBE3A, the gene associated with the neurogenetic disorder Angelman syndrome (AS), is imprinted in certain regions of normal brain, where it is expressed from the maternal allele only, while in most other tissues, the gene is biallelically expressed.
Sotirova, Vihra Nikolova
core  

O papel da Ube3A na diferenciação pré-sináptica

The decrease in UBE3A gene expression levels results in Angelman Syndrome, a rare neurodevelopmental disease characterized by cognitive and motor impairments, epilepsy and EEG abnormalities, as well as lack of speech and sleep difficulties.
Bruno, Inês Conceição Denis
core  

Adenosine Receptor Functionality and Desensitization Machinery in a Neuronal Cell Model of Angelman Syndrome. [PDF]

J Dev Biol
Contestabile M, Martins de Almeida JF, De Cesari C, Tonazzini I, Artini PG, Daniele S.   +5 more
europepmc   +1 more source

Lactate Dehydrogenase B Expression in Cerebellum of Adult <i>Ube3a</i> ^m-/p+ Mice. [PDF]

MicroPubl Biol
Ramos Rivera MA, Torres Ortiz C.
europepmc   +1 more source

Crossing the finish line towards a disease-modifying treatment for Angelman syndrome. [PDF]

J Neurodev Disord
Judson MC, de Almeida LP, Burdine RD, Chamberlain SJ, Deverman BE, Distel B, Ehlers MD, Jalazo E, Kushner SA, Nespeca M, Sanders SJ, Scheffner M, Yi JJ, Zylka MJ, Elgersma Y, Philpot BD.   +15 more
europepmc   +1 more source

A xenotransplantation model for reactivation of paternal UBE3A using human-specific antisense oligonucleotides. [PDF]

Sci Rep
Smeenk H, Lendemeijer B, Buurma MG, Forgione MA, Slump DE, Monshouwer RA, Wallaard I, Mientjes EJ, Hoogendijk WJG, Elgersma Y, de Vrij FMS, Kushner SA.   +11 more
europepmc   +1 more source

UBE3A-mediated mH2A1 Ubiquitination activates TERT transcription to promote senescence resistance in pancreatic cancer. [PDF]

Cell Death Dis
Ren L, Lu R, Fei X, Chen S, Liu P, Liu S, Zhu C, Shen X, Wang X, Pan Y.   +9 more
europepmc   +1 more source

HPV16 E6 oncoprotein promotes microhomology-mediated viral integration by increasing PolΘ protein expression. [PDF]

Proc Natl Acad Sci U S A
Zhu G, Asada S, Abeykoon JP, Sun L, Mukkavalli S, D'Andrea AD.   +5 more
europepmc   +1 more source

UBE3A isoform-selective and non-selective contributions to Angelman syndrome phenotypes. [PDF]

Mol Psychiatry
Krzeski JC, Mientjes EJ, Judson MC, Dong G, Hipp RI, Lien KH, Gu B, Philpot BD, Elgersma Y.   +8 more
europepmc   +1 more source

Ubenimex synergizes with the PD-L1 blockade in gastric cancer by competitively binding LAP3 with UBE3A. [PDF]

Cell Death Dis
Zhao C, Li J, Zheng J, Chi M, Shao Y, Che Y, Chen W, Dai J, Chen C, Li X, Zan L, Shi Y, Duan Y, Yang L, Yang T.   +14 more
europepmc   +1 more source