Results 261 to 270 of about 30,210 (297)

Ubiquitin-conjugating enzymes: novel regulators of eukaryotic cells

Trends in Biochemical Sciences, 1990
Covalent attachment of ubiquitin to cellular proteins is essential for cell viability and is catalysed by a set of distinct ubiquitin-conjugating enzymes. Individual members of this novel enzyme family mediate strikingly diverse functions, including DNA repair, cell cycle control, selective protein degradation and essential functions of the stress ...
Jentsch, S., Seufert, W., Sommer, T., Reins, H.   +3 more
openaire   +3 more sources

Characterization of the mouse ubiquitin-conjugating enzyme gene UbcM4

Mammalian Genome, 1999
The ubiquitination pathway targets not only normal (short-lived) intracellular eukaryotic proteins for degradation when appropriate, but also serves to eliminate mutant/misfolded proteins from the cell. An understanding of the molecular basis of the interaction between the ubiquitin-conjugating enzymes (E2s), ubiquitin protein ligases (E3s), and target
T P, Moynihan, U, Nuber, H C, Ardley, S A, Rose, A F, Markham, M, Scheffner, P A, Robinson   +6 more
openaire   +2 more sources

QRI8, a novel ubiquitin-conjugating enzyme in Saccharomyces cerevisiae

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1992
We have cloned and sequenced the gene encoding a novel ubiquitin-conjugating enzyme in Saccharomyces cerevisiae. Disruption of this gene shows that it is not essential for cell viability.
A, Vassal, A, Boulet, E, Decoster, G, Faye   +3 more
openaire   +2 more sources

Characterization of a human ubiquitin-conjugating enzyme gene UBE2L3

Mammalian Genome, 1996
Ubiquitin-conjugating enzymes (E2s) are essential components of the post-translational protein ubiquitination pathway, mediating the transfer of activated ubiquitin to substrate proteins. We have identified a human gene, UBE2L3, localized on Chromosome (Chr) 22q11.
T P, Moynihan, H C, Ardley, J P, Leek, J, Thompson, N S, Brindle, A F, Markham, P A, Robinson   +6 more
openaire   +2 more sources

An Altered-specificity Ubiquitin-conjugating Enzyme/Ubiquitin–Protein Ligase Pair

Journal of Molecular Biology, 2004
The human CCR4-NOT complex is a global regulator of RNA polymerase II transcription. Recently, we showed that the RING domain CNOT4 subunit contains intrinsic ubiquitin-protein ligase (E3) activity. Here we show that binding of the CNOT4 RING finger to the ubiquitin-conjugating enzyme (E2) UbcH5B is highly selective.
Winkler, GS, Albert, TK, Dominguez, C, Legtenberg, YI, Boelens, R, Timmers, HT   +5 more
openaire   +4 more sources

Location of ubiquitin conjugates and ubiquitin-conjugating enzymes in rabbit brain.

1991
The work reports the location of ubiquitin conjugates and ubiquitin-conjugating enzymes in homogenates of rabbit brain.
MAGNANI, MAURO, SERAFINI, GIORDANO, ANTONELLI, ANTONELLA, CRINELLI, RITA, Manuela Malatesta, Giancarlo Gazzanelli   +5 more
openaire   +2 more sources

BRUCE—a giant death-defying ubiquitin-conjugating enzyme

Trends in Cell Biology, 1998
Abstract HAUSER, H-P., BARDROFF, M., PYROWOLAKIS, G. and JENTSCH, S. (1998) A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors J. Cell Biol.
openaire   +1 more source

Metal–Organic Framework-Based Enzyme Biocomposites

Chemical Reviews, 2021
, Peter Wied, Francesco Carraro
exaly  

Bioinspired Framework Catalysts: From Enzyme Immobilization to Biomimetic Catalysis

Chemical Reviews, 2023
Kun-Yu Wang, Jiandong Pang, Wei Shi
exaly  

Expanding the Synthetic Toolbox through Metal–Enzyme Cascade Reactions

Chemical Reviews, 2023
Ivan Lavandera, Vicente Gotor-Fernández
exaly