Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu+4 more
wiley +1 more source
Computational Analysis of the Mechanism of the Ubiquitin Conjugating Enzyme Ubc13 [PDF]
Serban Zamfir+3 more
openaire +2 more sources
Molecular Mechanism of HINTW (HINT Gene in W-Chromosome)-Mediated UBE2I (Ubiquitin Conjugating Enzyme E2 I) Interaction in Female Differentiation of Chicken Embryos. [PDF]
Sun C+8 more
europepmc +1 more source
Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import
Scott M. Plafker+3 more
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A Functional Analysis of the Yeast Ubiquitin Ligase Rsp5: The Involvement of the Ubiquitin-Conjugating Enzyme Ubc4 and Poly-Ubiquitination in Ethanol-Induced Down-Regulation of Targeted Proteins [PDF]
Hiroyuki Hiraishi+3 more
openalex +1 more source
Cell Apoptosis and Glucocorticoid‐Induced Osteonecrosis
The review identifies glucocorticoid‐induced osteocyte/osteoblast apoptosis as central to femoral head osteonecrosis (GION), mediated through STAT1‐caspase‐3, PI3K/Akt, Wnt/β‐catenin, and oxidative stress pathways. Emerging therapies targeting these pathways (e.g., HIF‐1α stabilization, AMPK activation, and exosome‐mediated miRNA delivery) show ...
Xiumei Tang+7 more
wiley +1 more source
The Ubiquitin-Conjugating Enzyme E2 O (UBE2O) and Its Therapeutic Potential in Human Leukemias and Solid Tumors. [PDF]
Maffeo B, Cilloni D.
europepmc +1 more source
Overexpression of soybean ubiquitin-conjugating enzyme gene GmUBC2 confers enhanced drought and salt tolerance through modulating abiotic stress-responsive gene expression in Arabidopsis [PDF]
Guoan Zhou, Ruzhen Chang, Lijuan Qiu
openalex +1 more source