Results 241 to 250 of about 39,918 (341)

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

eLife Assessment: The ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during aging

Pablo Wappner
openalex   +1 more source

StUBC13, a Ubiquitin-Conjugating Enzyme, Positively Regulates Salt and Osmotic Stresses in Potato [PDF]

Xue Fu, Xun Tang, Ning Zhang, Huaijun Si
openalex   +1 more source

Hepatitis C Virus Downregulates Ubiquitin-Conjugating Enzyme E2S Expression To Prevent Proteasomal Degradation of NS5A, Leading to Host Cells More Sensitive to DNA Damage [PDF]

, 2018
Hang Pham, Tram Nguyen, Lap P. Nguyen, Sang‐Seop Han, Yun-Sook Lim, Soon B. Hwang   +5 more
openalex   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

A conserved asparagine has a structural role in ubiquitin-conjugating enzymes. [PDF]

Nat Chem Biol, 2013
Berndsen CE, Wiener R, Yu IW, Ringel AE, Wolberger C.   +4 more
europepmc   +1 more source

The Human COP9 Signalosome Protects Ubiquitin-conjugating Enzyme 3 (UBC3/Cdc34) from β-Transducin Repeat-containing Protein (βTrCP)-mediated Degradation [PDF]

, 2010
María Elena Fernández-Sánchez, Emmanuel Sechet, Florence Margottin-Goguet, Lars Rogge, Elisabetta Bianchi   +4 more
openalex   +1 more source

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

Involvement of Ubiquitin-Conjugating Enzyme E2C in Proliferation and Invasion of Prostate Carcinoma Cells

, 2014
Shuliang Song, Lei Cui, Jing Guangwu, Changjie Liu   +3 more
openalex   +1 more source

Unsaturated Phosphorus Electrophiles to Probe Protein Tyrosine Phosphatases

Angewandte Chemie International Edition, EarlyView.
Charged aryl‐ethynyl phosphonamidic and phosphonic acids are introduced as low‐reactivity electrophiles for peptide‐based activity probes that enable selective, target‐specific profiling of protein tyrosine phosphatases. The probes show no off‐target cysteine reactivity and engage only the interacting phosphatase in global proteomic analysis.
Eleftheria Poulou, Max Ruwolt, Christian E. Stieger, Kristin Kemnitz‐Hassanin, Christian P. R. Hackenberger   +4 more
wiley   +1 more source