Results 231 to 240 of about 617,710 (283)

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

Advanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken, Paula Beltran Lobo, Yunzhao Wu, Lyla A. Rowe, Emre Fertan, Cara L. Croft, Maria Jimenez‐Sanchez, Dezerae Cox, David Klenerman   +8 more
wiley   +1 more source

Ubiquitin beyond the proteome: lipids, glycans, metabolites, nucleic acids, and an expanding molecular landscape. [PDF]

Biochem Soc Trans
Endo A, Yoshida Y.
europepmc   +1 more source

Granzyme B PET Imaging Reveals Lgmn+ Macrophage‐Mediated Immune Evasion and Guides Immunotherapy in EGFR‐TKI‐Resistant NSCLC

Advanced Science, EarlyView.
Graphical illustration of 68Ga‐GZB PET/CT imaging reveals immune dynamics post‐EGFR‐TKI resistance in NSCLC; Lgmn+ macrophages‐derived Lgmn‐containing extracellular vesicles inhibit glycolysis, induce CD8+ T cell exhaustion, and targeting Lgmn restores immunotherapy sensitivity.
Dongliang Wang, Wenqin Luo, Qiufang Liu, Wenxuan Tang, Bin Zhu, Jiwei Chen, Qian Zhou, Shuang Tang, Xiaoping Xu, Shaoli Song   +9 more
wiley   +1 more source

Proteome analyses reveal endoplasmic reticulum stress-induced changes in protein abundance associated with Ube2j2 deficiency in human cell culture. [PDF]

G3 (Bethesda)
Dahlberg CL, Zinkgraf M, Laugesen SH, Søltoft CL, Ginebra Q, Bennett EP, Hartmann-Petersen R, Ellgaard L.   +7 more
europepmc   +1 more source

Porcine Reproductive and Respiratory Syndrome Virus NSP8 Suppresses NF-κB Signaling by Hijacking Host UBE2K and IKKα. [PDF]

Viruses
Liu D, Yan Y, Fu X, Qin L, Ma J, Zhou H, Sun S, Li H, Dong W, Zhou J.   +9 more
europepmc   +1 more source

UBE2D4 Upregulation Promotes Cuproptosis Sensitivity in Colorectal Cancer. [PDF]

Mol Genet Genomic Med
Wang B, Li C, Guo X, Liang Z.
europepmc   +1 more source

Multiple directed mutagenesis reduces enzymatic activity and antibody recognition of the African Swine Fever Virus E2 ubiquitin-conjugating protein (ASFV-pI215L). [PDF]

Emerg Microbes Infect
Jordão N, Urbano AC, Boinas F, Martins C, Ferreira F.   +4 more
europepmc   +1 more source

A Conserved Magnaporthe oryzae Effector Counteracts the Rice Ubiquitin-Proteasome System by Disrupting the E2 Function to Suppress Immunity. [PDF]

Plant Biotechnol J
Wang M, Wang R, Xiong Y, You X, Zhang F, Mao X, He F, Tao H, Jiang S, Fang L, Xu X, Wang J, Hao Z, Hou Y, Zhang H, Wang J, Zheng W, Sun W, Wang GL, Ning Y.   +19 more
europepmc   +1 more source

The role of E3 ubiquitin ligases in selective types of macroautophagy. [PDF]

EMBO Rep
Müller M, Winklhofer KF, Reggiori F.
europepmc   +1 more source

Location of ubiquitin conjugates and ubiquitin-conjugating enzymes in rabbit brain.

, 1991
The work reports the location of ubiquitin conjugates and ubiquitin-conjugating enzymes in homogenates of rabbit brain.
MAGNANI, MAURO, SERAFINI, GIORDANO, ANTONELLI, ANTONELLA, CRINELLI, RITA, Manuela Malatesta, Giancarlo Gazzanelli   +5 more
openaire   +3 more sources