Arabidopsis COP10 forms a complex with DDB1 and DET1 in vivo and enhances the activity of ubiquitin conjugating enzymes [PDF]
Genes & Development, 2004 COP10 is a ubiquitin-conjugating enzyme variant (UEV), which is thought to act together with COP1, DET1, and the COP9 signalosome (CSN) in Arabidopsis to repress photomorphogenesis.
Yuki Yanagawa +11 more
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Determinants of chemoselectivity in ubiquitination by the J2 family of ubiquitin-conjugating enzymes. [PDF]
EMBO JAbstractUbiquitin-conjugating enzymes (E2) play a crucial role in the attachment of ubiquitin to proteins. Together with ubiquitin ligases (E3), they catalyze the transfer of ubiquitin (Ub) onto lysines with high chemoselectivity. A subfamily of E2s, including yeast Ubc6 and human Ube2J2, also mediates noncanonical modification of serines, but the ...
Swarnkar A +9 more
europepmc +4 more sources
The Lysine Deprotonation Mechanism in a Ubiquitin Conjugating Enzyme. [PDF]
J Phys Chem BUbiquitination is a biochemical reaction in which a small protein, ubiquitin (Ub), is covalently linked to a lysine on a target protein. This type of post-translational modification can signal for protein degradation, DNA repair, or inflammation response.
Wathan AJ +3 more
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Echinococcus granulosus ubiquitin-conjugating enzymes (E2D2 and E2N) promote the formation of liver fibrosis in TGFβ1-induced LX-2 cells [PDF]
Parasites & VectorsBackground Cystic echinococcosis (CE) is a widespread zoonosis caused by the infection with Echinococcus granulosus sensu lato (E. granulosus s.l.). CE cysts mainly develop in the liver of intermediate hosts, characterized by the fibrotic tissue that ...
Xiaodi Du +6 more
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The Emerging Role and Mechanism of E2/E3 Hybrid Enzyme UBE2O in Human Diseases [PDF]
BiomedicinesThe ubiquitin–proteasome system (UPS) plays a pivotal role in determining protein fate, regulating signal transduction, and maintaining cellular homeostasis. Protein ubiquitination, a key post-translational modification, is orchestrated by the sequential
Qian Cheng +5 more
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Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins. [PDF]
EMBO Journal, 1990 Wolfgang Seufert, Stefan Jentsch
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Regulation of p53 by the Ubiquitin-conjugating Enzymes UbcH5B/C in Vivo* [PDF]
Journal of Biological Chemistry, 2004 p53 levels are regulated by ubiquitination and 26 S proteasome-mediated degradation. p53 is a substrate for the E3 ligase Mdm2, however, the ubiquitin-conjugating enzymes (E2s) involved in p53 ubiquitination in intact cells have not been defined previously.
M. Saville +7 more
semanticscholar +5 more sources
RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination. [PDF]
Biochim Biophys Acta, 2014 Metzger MB +3 more
europepmc +2 more sources
Targeting neddylation E2s: a novel therapeutic strategy in cancer
Journal of Hematology & Oncology, 2021 Ubiquitin-conjugating enzyme E2 M (UBE2M) and ubiquitin-conjugating enzyme E2 F (UBE2F) are the two NEDD8-conjugating enzymes of the neddylation pathway that take part in posttranslational modification and change the activity of target proteins.
Yi-Chao Zheng +6 more
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