Results 31 to 40 of about 617,710 (283)

The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity

Cell Reports, 2019
Summary: Ubiquitin and ubiquitin-like chains are finely balanced by conjugating and de-conjugating enzymes. Alterations in this balance trigger the response to stress conditions and are often observed in pathologies.
Aymeric P. Bailly, Aurelien Perrin, Marina Serrano-Macia, Chantal Maghames, Orsolya Leidecker, Helene Trauchessec, M.L. Martinez-Chantar, Anton Gartner, Dimitris P. Xirodimas   +8 more
doaj   +1 more source

The ubiquitin-proteasome system is required for African swine fever replication. [PDF]

PLoS ONE, 2017
Several viruses manipulate the ubiquitin-proteasome system (UPS) to initiate a productive infection. Determined viral proteins are able to change the host's ubiquitin machinery and some viruses even encode their own ubiquitinating or deubiquitinating ...
Lucía Barrado-Gil, Inmaculada Galindo, Diego Martínez-Alonso, Sergio Viedma, Covadonga Alonso   +4 more
doaj   +1 more source

TULIP2: An Improved Method for the Identification of Ubiquitin E3-Specific Targets

Frontiers in Chemistry, 2019
Protein modification by Ubiquitin or Ubiquitin-like modifiers is mediated by an enzyme cascade composed of E1, E2, and E3 enzymes. E1s, or ubiquitin-activating enzymes, perform ubiquitin activation. Next, ubiquitin is transferred to ubiquitin-conjugating
Daniel Salas-Lloret, Giulia Agabitini, Román González-Prieto   +2 more
doaj   +1 more source

The HIP2~ubiquitin conjugate forms a non-compact monomeric thioester during di-ubiquitin synthesis. [PDF]

PLoS ONE, 2015
Polyubiquitination is a post-translational event used to control the degradation of damaged or unwanted proteins by modifying the target protein with a chain of ubiquitin molecules.
Benjamin W Cook, Kathryn R Barber, Brian H Shilton, Gary S Shaw   +3 more
doaj   +1 more source

Structural Diversity of Ubiquitin E3 Ligase

Molecules, 2021
The post-translational modification of proteins regulates many biological processes. Their dysfunction relates to diseases. Ubiquitination is one of the post-translational modifications that target lysine residue and regulate many cellular processes ...
Sachiko Toma-Fukai, Toshiyuki Shimizu
doaj   +1 more source

Crystal structure of UBA2ufd-Ubc9: insights into E1-E2 interactions in sumo pathways [PDF]

, 2010
Canonical ubiquitin-like proteins (UBLs) such as ubiquitin, Sumo, NEDD8, and ISG15 are ligated to targets by E1-E2-E3 multienzyme cascades. The Sumo cascade, conserved among all eukaryotes, regulates numerous biological processes including protein ...
Miller, D.J., Asad M Taherbhoy, Schulman, B.A., Darcie J Miller, Steven N Seyedin, Huang Danny T., Wang, J., Kobe, B., Steven N. Seyedin, Seyedin Steven N., David W. Miller, Miller David W., Darcie J. Miller, Hunt Harold W., Miller, D.W., Taherbhoy, A.M., Danny T. Huang, Brenda A. Schulman, Miller Darcie J., Danny T Huang, Wang Jing, Harold W. Hunt, Harold W Hunt, Asad M. Taherbhoy, Schulman Brenda A., Jing Wang, Huang, D.T., Taherbhoy Asad M., David W Miller, Hunt, H.W., Seyedin, S.N., Brenda A Schulman   +31 more
core   +2 more sources

UBE2G1 governs the destruction of cereblon neomorphic substrates

eLife, 2018
The cereblon modulating agents (CMs) including lenalidomide, pomalidomide and CC-220 repurpose the Cul4-RBX1-DDB1-CRBN (CRL4CRBN) E3 ubiquitin ligase complex to induce the degradation of specific neomorphic substrates via polyubiquitination in ...
Gang Lu, Stephanie Weng, Mary Matyskiela, Xinde Zheng, Wei Fang, Scott Wood, Christine Surka, Reina Mizukoshi, Chin-Chun Lu, Derek Mendy, In Sock Jang, Kai Wang, Mathieu Marella, Suzana Couto, Brian Cathers, James Carmichael, Philip Chamberlain, Mark Rolfe   +17 more
doaj   +1 more source

Pleiotropic Roles of a KEAP1-Associated Deubiquitinase, OTUD1

Antioxidants, 2023
Protein ubiquitination, which is catalyzed by ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin ligases, is a crucial post-translational modification to regulate numerous cellular functions in a spatio–temporal-specific manner ...
Daisuke Oikawa, Kouhei Shimizu, Fuminori Tokunaga   +2 more
doaj   +1 more source

Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase η in Saccharomyces cerevisiae [PDF]

, 2007
Bypassing of DNA lesions by damage-tolerant DNA polymerases depends on the interaction of these enzymes with the monoubiquitylated form of the replicative clamp protein, PCNA.
Bielen, Aleksandra B., Ulrich, Helle D., Parker, Joanne L., Đikić, Ivan   +3 more
core   +1 more source

Determinants of Functionality in the Ubiquitin Conjugating Enzyme Family [PDF]

Structure, 2004
The E2 enzymes are key enzymes in the ubiquitin and ubiquitin-like protein ligation pathways. To understand the functionality of the different E2 enzymes, we analyzed 190 protein sequences and 211 structures and electrostatic potentials. Key findings include: The ScUbc1 orthologs are defined by a C-terminal UBA domain. An N-terminal sequence motif that
Winn, Peter J., Religa, Tomasz L., Battey, James N.D., Banerjee, Amit, Wade, Rebecca C.   +4 more
openaire   +2 more sources