Results 61 to 70 of about 63,885 (332)

Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes

Nature Communications, 2017
The transfer of ubiquitin (UB) to cellular targets is mediated sequentially by three groups of enzymes, UB activating enzyme (E1), UB conjugating enzyme (E2) and UB ligase (E3).
Xianpeng Liu, Bo Zhao, Limin Sun, Karan Bhuripanyo, Yiyang Wang, Yingtao Bi, Ramana V. Davuluri, Duc M. Duong, Dhaval Nanavati, Jun Yin, Hiroaki Kiyokawa   +10 more
doaj   +1 more source

Ubiquitin-Conjugating Enzyme OsUBC11 Affects the Development of Roots via Auxin Pathway

Rice, 2023
Rice has 48 ubiquitin-conjugating enzymes, and the functions of most of these enzymes have not been elucidated. In the present study, a T-DNA insertional mutant named R164, which exhibited a significant decrease in the length of primary and lateral roots,
Yunfei Han, Chuanzhong Zhang, Hanjing Sha, Xiaojing Wang, Yue Yu, Jia Liu, Guangxin Zhao, Jingying Wang, Guankai Qiu, Xingjian Xu, Jun Fang   +10 more
doaj   +1 more source

Genome-Wide Identification, Phylogenetic and Expression Analyses of the Ubiquitin-Conjugating Enzyme Gene Family in Maize.

PLoS ONE, 2015
BackgroundUbiquitination is a post-translation modification where ubiquitin is attached to a substrate. Ubiquitin-conjugating enzymes (E2s) play a major role in the ubiquitin transfer pathway, as well as a variety of functions in plant biological ...
Dengwei Jue, Xuelian Sang, Shengqiao Lu, Chen Dong, Qiufang Zhao, Hongliang Chen, Liqiang Jia   +6 more
doaj   +1 more source

SUMO modification of the ubiquitin-conjugating enzyme E2-25K

Nature Structural & Molecular Biology, 2005
Post-translational modification with small ubiquitin-related modifier (SUMO) alters the function of many proteins, but the molecular mechanisms and consequences of this modification are still poorly defined. During a screen for novel SUMO1 targets, we identified the ubiquitin-conjugating enzyme E2-25K (Hip2).
Edith Oberhofer, Puck Knipscheer, Frauke Melchior, Frauke Melchior, Stefan Jentsch, Roman Körner, Titia K. Sixma, Jesper V. Olsen, A. Pichler, A. Pichler, Willem J. van Dijk   +10 more
openaire   +5 more sources

Targeting the ubiquitin system by fragment-based drug discovery

Frontiers in Molecular Biosciences, 2022
The ubiquitin system contains a wealth of potential drug targets for many diseases and conditions, including neurodegenerative, immune, metabolic and developmental diseases, as well as multiple cancers.
Cassandra Kennedy, Katherine McPhie, Katrin Rittinger   +2 more
doaj   +1 more source

Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: a key role for ubiquitin-conjugating enzymes.

European Heart Journal, 2011
AIMS Mice with a cardiomyocyte (CM)-restricted knockout of signal transducer and activator of transcription 3 (STAT3-KO) develop spontaneous heart failure.
A. Haghikia, E. Missol-Kolka, D. Tsikas, L. Venturini, S. Brundiers, M. Castoldi, M. Muckenthaler, M. Eder, B. Stapel, T. Thum, A. Haghikia, E. Petrasch‐Parwez, H. Drexler, D. Hilfiker-Kleiner, M. Scherr   +14 more
semanticscholar   +1 more source

Redirecting the specificity of ubiquitination by modifying ubiquitin-conjugating enzymes. [PDF]

Proceedings of the National Academy of Sciences, 1995
Depletion of specific cellular proteins is a powerful tool in biological research and has many medical and agricultural benefits. In contrast to genetic methods currently available to attenuate protein levels, we describe an alternative approach that redirects the ubiquitin-dependent proteolytic pathway to facilitate specific proteolytic removal ...
Mark Gosink, Richard D. Vierstra
openaire   +3 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity

Nature Communications, 2017
The RIG-I-MAVS signalling pathway plays an important role in sensing virus infection. Here the authors identify the ubiquitin-conjugating enzymes Ube2D3 and Ube2N as essential for RIG-I activation and define their roles in mediating MAVS aggregation.
Yuheng Shi, Bofeng Yuan, Wenting Zhu, Rui Zhang, Lin Li, Xiaojing Hao, She Chen, Fajian Hou   +7 more
doaj   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source