Results 191 to 200 of about 164,141 (292)

Genotype-by-environment interactions shape ubiquitin-proteasome system activity. [PDF]

Genetics
Avery RR, Collins MA, Albert FW.
europepmc   +1 more source

β‐Aminoisobutyric Acid Alleviates Cisplatin‐Induced Muscle Atrophy by Regulating E3 Ubiquitin Ligases, Apoptosis, Amino Acid Metabolism, Autophagy, and Ferroptosis

Medicine Bulletin, EarlyView.
ABSTRACT Background Cisplatin (CIS) is a widely used broad‐spectrum anticancer agent, but its clinical application is often limited by severe adverse effects, including skeletal muscle atrophy, which compromises patients' quality of life and treatment efficacy.
Hao‐Zhe Wang, Wen‐Bi He, Huan Wang, Hao Wang, Wen‐Jun Fang, Meng‐Qian Li, Jiong‐Xing Huang, Fei‐Peng Chen, Hui‐Guo Wang, Lin Zhu, Xiao‐Guang Liu   +10 more
wiley   +1 more source

Dual Targeting of IDH2 and the Ubiquitin-Proteasome System Reveals a Functional Vulnerability in Breast Cancer Models. [PDF]

Cancers (Basel)
Gharari N, Mereu E, Luciano B, Heidari B, Mader S, Piva R.   +5 more
europepmc   +1 more source

Dysregulation of the ubiquitin-proteasome system in von Hippel-Lindau syndrome: molecular insights and clinical perspectives. [PDF]

Clin Exp Med
Bi Y, Wang R, Li L, Wang L, Chen X, Nie X, Meng J, Cai S.   +7 more
europepmc   +1 more source

A poliubiquitin receptorok fejlődésstádium-specifikus szabályozása Drosophila melanogasterben [PDF]

, 2009
Lipinszki Zoltán
core  

CRISPR‐Cas9 Genome‐Wide Screening in Paediatric Cancer: Functional Genomics for Target Discovery and the Improvement of Existing Therapies

Medicinal Research Reviews, EarlyView.
ABSTRACT CRISPR‐Cas9 genome‐wide screening has been instrumental towards identifying novel targets for drug discovery in cancer research. However, much of this research has centred specifically on adult cancers, with paediatric cancers being underserviced by current research and screening.
Steven He, Patrick Connerty, Antoine de Weck   +2 more
wiley   +1 more source

Harnessing Ubiquitin-Proteasome System-Related Genes to Identify Subtypes of Bladder Cancer and Reveal Immune Landscape. [PDF]

Am J Mens Health
Shi G, Zhou X, Yang F, Wang T.
europepmc   +1 more source

Neuroprotective effects of ursodeoxycholic acid in Parkinson's disease and Alzheimer's disease

Neuroprotection, EarlyView.
In Parkinson's disease (PD) and Alzheimer's disease (AD), various shared pathological mechanisms exist. UDCA has been shown to exert neuroprotective effects in preclinical and clinical studies. Such effects include the mitigation of neuroinflammation as well as rescue effects on mitochondrial dysfunction, oxidative stress, impaired autophagy, and ...
Ashley En Yi Chong, Andrew Octavian Sasmita, Rhun Yian Koh, Anna Pick Kiong Ling   +3 more
wiley   +1 more source

Tomato antiviral ubiquitin-proteasome system recognizes viral 59 kDa protein to confer tomato chlorosis virus resistance. [PDF]

Nat Commun
Zhao D, Liu X, Li H, Xia T, Jia Q, Li P, Shan Q, Li C, Li H, Gai Y, Lin T, Zang L, Zhou T, Wei JW, Zhu X, Gong B.   +15 more
europepmc   +1 more source

A DUF3455 domain‐containing protein promotes Ustilaginoidea virens infection and functions as a plant immune elicitor

New Plant Protection, EarlyView.
The fungal effector UvDUF1 from Ustilaginoidea virens not only promotes infection but also acts as a plant immunity elicitor, inducing broad‐spectrum disease resistance in rice and Nicotiana benthamiana. These results reveal its potential as a novel target for sustainable crop protection strategies.
Shuchen Wang, Wen Zhang, Wenyue Zheng, Qian Zhang, Mina Yu, Junjie Yu, Huijuan Cao, Xiayan Pan, Zhongqiang Qi, Yan Du, Rongsheng Zhang, Yunpeng Wang, Yongfeng Liu, Tianqiao Song   +13 more
wiley   +1 more source