Results 91 to 100 of about 129,362 (255)
Optimal experimental design in an EGFR signaling and down-regulation model [PDF]
arXiv, 2006 We apply the methods of optimal experimental design to a differential equation model for epidermal growth factor receptor (EGFR) signaling, trafficking, and down-regulation. The model incorporates the role of a recently discovered protein complex made up of the E3 ubiquitin ligase, Cbl, the guanine exchange factor (GEF), Cool-1 (Beta-Pix), and the Rho ...
arxiv
E3 Ubiquitin Ligases: Potential Therapeutic Targets for Skeletal Pathology and Degeneration
Stem Cells International, 2022 The ubiquitination-proteasome system (UPS) is crucial in regulating a variety of cellular processes including proliferation, differentiation, and survival. Ubiquitin protein ligase E3 is the most critical molecule in the UPS system.
Ruiyin Zeng +6 more
doaj +1 more source
Virology, 2000 Latent membrane protein 2A (LMP2A) is expressed in latent Epstein-Barr virus (EBV) infection. LMP2A functions to downregulate B-cell signal transduction and viral reactivation from latency in EBV-immortalized B cells in vitro, and acts to provide B cells
M. Ikeda +3 more
semanticscholar +1 more source
The APC/C Ubiquitin Ligase: from Cell Biology to Tumorigenesis
Frontiers in Oncology, 2012 The ubiquitin proteasome system (UPS) is required for normal cell proliferation, vertebrate development, and cancer cell transformation. The UPS consists of multiple proteins that work in concert to target a protein for degradation via the 26S proteasome.
Clara ePenas +2 more
doaj +1 more source
Deciding Whether a Regular Language is Generated by a Splicing System [PDF]
arXiv, 2011 Splicing as a binary word/language operation is inspired by the DNA recombination under the action of restriction enzymes and ligases, and was first introduced by Tom Head in 1987. Shortly thereafter, it was proven that the languages generated by (finite) splicing systems form a proper subclass of the class of regular languages.
arxiv
Splicing Systems from Past to Future: Old and New Challenges [PDF]
arXiv, 2015 A splicing system is a formal model of a recombinant behaviour of sets of double stranded DNA molecules when acted on by restriction enzymes and ligase. In this survey we will concentrate on a specific behaviour of a type of splicing systems, introduced by P\u{a}un and subsequently developed by many researchers in both linear and circular case of ...
arxiv
Modeling PROTAC Degradation Activity with Machine Learning [PDF]
Artificial Intelligence in the Life Sciences, Volume 6, 2024,
100104PROTACs are a promising therapeutic modality that harnesses the cell's built-in degradation machinery to degrade specific proteins. Despite their potential, developing new PROTACs is challenging and requires significant domain expertise, time, and cost. Meanwhile, machine learning has transformed drug design and development.
arxiv +1 more source
Ubiquitination Assay for Mammalian Cells
Bio-Protocol, 2016 Ubiquitin is an 8.5 kDa protein that can be activated and conjugated by ubiquitin-activating enzyme E1 and ubiquitin-conjugating enzyme E2, respectively.
Yang Peng +3 more
doaj +1 more source
A Key Role for the Ubiquitin Ligase UBR4 in Myofiber Hypertrophy in Drosophila and Mice
Cell Reports, 2019 Summary: Skeletal muscle cell (myofiber) atrophy is a detrimental component of aging and cancer that primarily results from muscle protein degradation via the proteasome and ubiquitin ligases.
Liam C. Hunt +11 more
doaj
Cell Research, 2013 The SCF (SKP1 (S-phase-kinase-associated protein 1), Cullin-1, F-box protein) E3 ubiquitin ligases, the founding member of Cullin-RING ligases (CRLs), are the largest family of E3 ubiquitin ligases in mammals.
Weihua Zhou, Wenyi Wei, Yi Sun
semanticscholar +1 more source