Results 111 to 120 of about 80,046 (337)

Gal3‐CaN‐Smurf1 Complex Sequestrates FLCN‐FNIPs to Facilitate TFEB Activation in Response to Endomembrane Damage

Advanced Science, EarlyView.
The schematic diagram illustrates the role of the recruitment of Gal3‐CaN‐Smurf1 complex in maintaining lysosomal membrane homeostasis upon damage. On the one hand, the Gal3‐CaN‐Smurf1 complex sequesters FLCN‐FNIPs to block the activation of RagC, where the active form RagC‐GDP is responsible for TFEB phosphorylation.
Qin Xia, Ziwan Liu, Gaoqing Feng, Wanting Xu, HuaHua Wang, Haihang Su, Jiaqian Li, Dan Liu, Jun Qu, Tonghui Yu, Lei Dong   +10 more
wiley   +1 more source

The APC/C Ubiquitin Ligase: from Cell Biology to Tumorigenesis

Frontiers in Oncology, 2012
The ubiquitin proteasome system (UPS) is required for normal cell proliferation, vertebrate development, and cancer cell transformation. The UPS consists of multiple proteins that work in concert to target a protein for degradation via the 26S proteasome.
Clara ePenas, Vimal eRamachandran, Nagi George Ayad   +2 more
doaj   +1 more source

The ubiquitin-proteasome pathway in Huntington's disease. [PDF]

, 2008
The accumulation of mutant protein is a common feature of neurodegenerative disease. In Huntington's disease, a polyglutamine expansion in the huntingtin protein triggers neuronal toxicity.
Finkbeiner, Steven, Mitra, Siddhartha
core   +2 more sources

FBXO44 Regulates FOXP1 Degradation Through AURKA‐Dependent Phosphorylation to Promote Colorectal Cancer Progression

Advanced Science, EarlyView.
FBXO44 promotes colorectal cancer progression by targeting FOXP1 for ubiquitin‐mediated degradation. This study reveals a phosphorylation‐dependent mechanism involving AURKA and highlights the FBXO44/FOXP1/Cyclin E2 axis as a potential therapeutic target in colorectal cancer.
Hongxu Nie, Hengjie Xu, Sheng Yang, Chuanxin Tian, Tuo Wang, Chi Jin, Zhihao Chen, Xiaowei Wang, Junwei Tang, Yifei Feng, Yueming Sun   +10 more
wiley   +1 more source

Regulation of human papillomavirus E6 oncoprotein function via a novel ubiquitin ligase FBXO4

mBio
Previous studies have shown that E6 interacts with the E6-associated protein (E6AP) ubiquitin-protein ligase and directs its ubiquitylation activity toward several specific cellular proteins, one of the most important of which is p53. Interestingly, E6AP
Arushi Vats, Luca Braga, Nezka Kavcic, Paola Massimi, Edoardo Schneider, Mauro Giacca, Laimonis A. Laimins, Lawrence Banks   +7 more
doaj   +1 more source

Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases [PDF]

, 2013
The SCF (SKP1 (S-phase-kinase-associated protein 1), Cullin-1, F-box protein) E3 ubiquitin ligases, the founding member of Cullin-RING ligases (CRLs), are the largest family of E3 ubiquitin ligases in mammals.
Sun, Yi, Wei, Wenyi, Zhou, Weihua
core   +1 more source

Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5

Advanced Science, EarlyView.
Okanin suppresses colorectal cancer growth by directly targeting PRDX5. This natural compound selectively binds peroxiredoxin 5 (PRDX5), inhibiting its activity and inducing WSB1‐mediated degradation. PRDX5 loss elevates ROS, suppresses GPX4 via SIAH2, and further triggers cell death (apoptosis and ferroptosis).
Ji Zhong Zhao, Yuan Fei Li, Fu Kang Yuan, Meng Lu Zhao, Ya Wen Han, Jia Xin Wang, Qi Yang, Han Ying Ye, Yu Cheng Lu, Shao Chin Lee   +9 more
wiley   +1 more source

A Tobacco Homolog of DCN1 is Involved in Cellular Reprogramming and in Developmental Transitions [PDF]

, 2011
Plant proteomes show remarkable plasticity in reaction to environmental challenges and during developmental transitions. Some of this adaptability comes from ubiquitin-mediated protein destruction regulated by cullin-RING E3 ubiquitin ligases (CRLs ...
Alexandra Ribarits, Alisher Tashpulatov, Alisher Touraev, Christina Friedmann, Elisabeth Ankele, Erwin Heberle-Bors, Julia Hosp, Katarzyna Szaszka, Klaus Palme, Marina Baumann, Tatiana Resch, Viktor Voronin, Yongfeng Jin   +12 more
core   +1 more source

SCF E3 Ligase Substrates Switch from CAN-D to Can-ubiquitylate

, 2018
Liu et al. (2018) report a mathematical model predicting how the cellular repertoire of SCF E3 ligases is assembled by “adaptive exchange on demand,” with the limited pool of CUL1 scanning the vast sea of F-box proteins for those with substrates ...
Schulman, B., Scott, D.
core   +1 more source

Ubiquitination accomplished: E1 and E2 enzymes were not necessary [PDF]

, 2016
Qiu et al. (2016) show that a mono-ADP-ribosyltransferase, SdeA, from Legionella pneumophila catalyzes ADP-ribosylation of ubiquitin, allowing SdeA to modify substrate with ubiquitin in the absence of E1 and E2 ...
Huang, Danny T., Nakasone, Mark
core   +1 more source