Results 131 to 140 of about 81,275 (289)

Publisher's Note: Cilia-localized GID/CTLH ubiquitin ligase complex regulates protein homeostasis of sonic hedgehog signaling components

, 2022
Friederike Hantel, Huaize Liu, Lisa Fechtner, Herbert Neuhaus, Jie Ding, Danilo Arlt, Peter Walentek, Pablo Villavicencio‐Lorini, Christoph Gerhardt, Thomas Hollemann, Thorsten Pfirrmann   +10 more
openalex   +2 more sources

Tumor‐Derived CDC37 Inhibits Antigen Cross‐Presentation in Dendritic Cells and Impairs Anti‐Tumor Immunity in Breast Cancer

Advanced Science, EarlyView.
Extracellular vesicle (EV)‐packaged CDC37 are released from TMBhiCTLlo breast cancer cells with high CDC37 expression, and internalized into endo/phagosomes of dendritic cells (DCs). Within these compartments, CDC37 locked HSP90–antigen complex, preventing antigen release into the cytosol.
Ruxin Wang, Yunyi Zhang, Xiangyu Meng, Jianli Zhao, Yue Xing, Qian Ouyang, Ning Zhang, Huiping Chen, Nanyan Miao, Erwei Song, Di Huang   +10 more
wiley   +1 more source

TIF1γ Protein Regulates Epithelial-Mesenchymal Transition by Operating as a Small Ubiquitin-like Modifier (SUMO) E3 Ligase for the Transcriptional Regulator SnoN1 [PDF]

, 2014
Yoshiho Ikeuchi, Shorafidinkhuja Dadakhujaev, Amrita Singh Chandhoke, Mai Anh Huynh, Anna Oldenborg, Mikako Ikeuchi, Lili Deng, Eric J. Bennett, J. Wade Harper, Azad Bonni, Shirin Bonni   +10 more
openalex   +1 more source

Hepatocyte‐Derived Extracellular Vesicles Deliver miR‐328‐3p to Trigger PP2A‐B56δ–Mediated p‐NLRP3S295‐Dependent Metaflammation in Macrophages upon Microcystin‐LR Exposure

Advanced Science, EarlyView.
Hepatocyte‐derived extracellular vesicles deliver miR‐328‐3p to trigger PP2A‐B56δ–mediated p‐NLRP3S295‐dependent metaflammation in macrophages upon microcystin‐LR exposure. 2‐DG, 2‐deoxy‐D‐glucose. B56δ, protein phosphatase 2A‐B56δ. ER, endoplasmic reticulum. iHD‐EV, inducible hepatocyte‐derived extracellular vesicles. IP3R, inositol 1,4,5‐triphosphate
Jia‐Shen Wu, Xin‐Yu Zhang, Xin‐Yu Ma, Yue‐Yue Wei, Lei‐Lei Wang, Ze‐Bang Du, Xiao‐Gang Xia, Lin Che, Dong‐Bei Guo, Han‐Ying Zheng, You‐Liang Yao, Wen‐Gang Li, Yu‐Chun Lin, Zhong‐Ning Lin   +13 more
wiley   +1 more source

Identification of RFPL3 Protein as a Novel E3 Ubiquitin Ligase Modulating the Integration Activity of Human Immunodeficiency Virus, Type 1 Preintegration Complex Using a Microtiter Plate-based Assay [PDF]

, 2014
Beng Hui Tan, Yasutsugu Suzuki, Hirotaka Takahashi, Pamela Ho Rui Ying, Chikako Takahashi, Qi’En Han, Wei-Xin Chin, Sheng‐Hao Chao, Tatsuya Sawasaki, Naoki Yamamoto, Youichi Suzuki   +10 more
openalex   +1 more source

METTL10‐Mediated PIAS3 Methylation Links Purine Metabolism to Gastric Cancer Progression

Advanced Science, EarlyView.
METTL10‐mediated methylation of PIAS3 at K442 inhibits its SUMO E3 ligase activity toward MITF. This reduces MITF SUMOylation and subsequent RNF4‐mediated ubiquitination, leading to MITF protein accumulation and gastric cancer progression. Abstract Metabolic dysregulation plays a significant role in the development of gastric cancer (GC).
Jinshui Tan, Huiwen Zhou, Jingsong Ma, Chensong Zhang, Yuhua Tan, Baoding Zhang, Jiabao Zhao, Ao Cheng, Chengyu Yang, Meijuan Xu, Shengyi Zhou, Yubo Xiong, Zeyang Lin, Guangchao Pan, Wenjie Ye, Mengya Zhong, Yang Yang, Yifan Zhuang, Shao‐Wei Li, Xianming Deng, Xuehui Hong   +20 more
wiley   +1 more source

Functional characterization of Cullin-1-RING ubiquitin ligase (CRL1) complex in Leishmania infantum.

PLoS Pathogens
Cullin-1-RING ubiquitin ligases (CRL1) or SCF1 (SKP1-CUL1-RBX1) E3 ubiquitin ligases are the largest and most extensively investigated class of E3 ligases in mammals that regulate fundamental processes, such as the cell cycle and proliferation.
Camila Rolemberg Santana Travaglini Berti de Correia, Caroline Torres, Ellen Gomes, Giovana Maffei Rodriguez, Wesley Klaysson Pereira Regatieri, Nayore Tamie Takamiya, Luana Aparecida Rogerio, Iran Malavazi, Marcelo Damário Gomes, Jeziel Dener Damasceno, Vitor Luiz da Silva, Marcos Antonio Fernandes de Oliveira, Marcelo Santos da Silva, Alessandro Silva Nascimento, Adriano Cappellazzo Coelho, Sandra Regina Maruyama, Felipe Roberti Teixeira   +16 more
doaj   +1 more source

Drosophila Roc1a Encodes a RING-H2 Protein with a Unique Function in Processing the Hh Signal Transducer Ci by the SCF E3 Ubiquitin Ligase

, 2021
Maher Noureddine, Timothy Donaldson, Stephen B. Thacker, Robert J. Duronio   +3 more
openalex   +1 more source

YKT6 Promotes Bladder Cancer Progression by Stabilizing β‐catenin Through USP7‐Mediated Deubiquitination

Advanced Science, EarlyView.
The SNARE protein YKT6 is upregulated in bladder cancer (BLCA), correlating with poor prognosis. YKT6 promotes tumor proliferation and metastasis by activating Wnt/β‐catenin signaling. It recruits Ubiquitin‐Specific Peptidase 7 (USP7) to deubiquitinate and stabilize β‐catenin, enhancing its nuclear accumulation and driving oncogenic gene expression ...
Sheng Tu, Wenzhi Du, Yongwen Luo, Jiageng Shi, Tianyun Liu, Meng Ji, Kangping Xiong, Siming Chen, Fenfang Zhou, Mingxing Li, Jingtian Yu, Gang Wang, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Kaiyu Qian   +16 more
wiley   +1 more source

Role of the C‐terminus of Saccharomyces cerevisiae ubiquitin‐conjugating enzyme (Rad6) in substrate and ubiquitin‐protein‐ligase (E3‐R) interactions [PDF]

, 1994
Bilha Raboy, Richard G. Kulka
openalex   +1 more source