Results 201 to 210 of about 81,275 (289)

Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S‐Adenosylmethionine Cycle

Advanced Science, EarlyView.
USP30 deubiquitinates and stabilizes MAT2A, thereby regulating DNA methylation and miRNA expression, which ultimately leads to disruption of lung endothelial barrier and inflammation. Abstract Microvascular dysfunction is a key contributor to the development of acute inflammatory diseases, characterized by heightened vascular hyperpermeability and ...
Baoyinna Baoyinna, Jinshan He, Jiaxing Miao, Nargis Shaheen, Boyu Xia, Cankun Wang, Qin Ma, Matthew C Bernier, Bryan A Whitson, Nuo Sun, Jing Zhao, Yutong Zhao   +11 more
wiley   +1 more source

The role of ubiquitin ligases in regulating immune cell functions. [PDF]

Front Immunol
Marty SE, Yip L, Wang F, Kumar M, Fathman CG.   +4 more
europepmc   +1 more source

Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases. [PDF]

PeerJ, 2016
Boomsma W, Nielsen SV, Lindorff-Larsen K, Hartmann-Petersen R, Ellgaard L.   +4 more
europepmc   +1 more source

THE POLYMORPHISM R441Q OF THE CHICKEN WWP1 UBIQUITIN PROTEIN LIGASE AFFECTS ITS FUNCTIONAL AND STRUCTURAL PROPRIETIES: POSSIBLE IMPLICATIONS TO GENETIC MUSCULAR DYSTROPHY / O POLIMORFISMO R441Q DA ENZIMA LIGASE WWP1 DA PROTEÍNA UBIQUITINA DE GALINHA AFETA SUAS PROPRIEDADES FUNCIONAIS E ESTRUTURAIS: POSSÍVEIS IMPLICAÇÕES À DISTROFIA MUSCULAR GENÉTICA

, 2021
Jane Eyre Gabriel
openalex   +1 more source

NUSAP1 Recruits DAXX to Suppress HIF‐Driven Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
A double‐negative feedback loop is identified in TNBC where NUSAP1 bridges HIF and DAXX via its microtubule‐associated domain (MAD) to recruit SETDB1, repressing HIF transcriptional activity by depositing the H3K9me3 repressive mark on HIF target genes, while HIF itself suppresses NUSAP1.
Yating Du, Jingjing Wang, Min Wang, Yao Zhang, Miaomiao Zheng, Huiyan Li, Xuemeng Wang, Huanran Sun, Kexin Tang, Changliang Shan, Qiang Zhao, Xiaoqian Meng, Yijie Wang, Jun Zhou, Yan Chen   +14 more
wiley   +1 more source

Substrate structure determines p97- and RAD23A/B-mediated proteasomal degradation in human cells. [PDF]

J Biochem
Ding Y, Tomita T, Tsuchiya H, Saeki Y.
europepmc   +1 more source

Potential Role of E3 Ubiquitin Protein Ligase in Traumatic Brain Injury Induced Autophagy

, 2020
Yuyang Tian
openalex   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

Role of Ubiquitin-regulated EMT in Cancer Metastasis and Chemoresistance. [PDF]

Int J Biol Sci
Xiao S, Tian L, Gan X, Xu X, Liao M, Song D, Yu Y, Qin W, Zhang R, Lyu H, Guo D, Zhang Q, Chen XZ, Zhou C, Tang J.   +14 more
europepmc   +1 more source

Evolutionary Divergence of an Ethylene‐Responsive Transcriptional Cascade Governs a Dose‐Dependent Balance between Cotton Fiber Length and Strength

Advanced Science, EarlyView.
A tunable, ethylene‐responsive cascade governing the dose‐dependent balance between fiber length and strength is unveiled. Elevated ethylene strengthens modern tetraploid cotton (G. hirsutum) fibers but elongates those of its diploid ancestor (G. arboreum). This phenotypic switch is traced to an evolutionary functional inversion of a conserved EIN3‐ERF‐
Jie Zhang, Mengli Yu, Yuling Guo, Jie Li, Gailing Gu, Ghulam Hussain, Shuya Ma, Fuguang Li, Hongwei Xue, Zhaoen Yang, Zuoren Yang   +10 more
wiley   +1 more source