Results 51 to 60 of about 129,362 (255)

Ubiquitin Ligases at the Heart of Skeletal Muscle Atrophy Control

Molecules, 2021
Skeletal muscle loss is a detrimental side-effect of numerous chronic diseases that dramatically increases mortality and morbidity. The alteration of protein homeostasis is generally due to increased protein breakdown while, protein synthesis may also be
Dulce Peris-Moreno, Laura Cussonneau, Lydie Combaret, Cécile Polge, Daniel Taillandier   +4 more
doaj   +1 more source

SIAH1 (siah E3 ubiquitin protein ligase 1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013
Review on SIAH1 (siah E3 ubiquitin protein ligase 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Nagano, Y, Matsuzawa, SI
openaire   +2 more sources

TRIM56 coiled-coil domain structure provides insights into its E3 ligase functions

Computational and Structural Biotechnology Journal, 2023
Protein ubiquitination is a post-translation modification mediated by E3 ubiquitin ligases. The RING domain E3 ligases are the largest family of E3 ubiquitin ligases, they act as a scaffold, bringing the E2-ubiquitin complex and its substrate together to
Xiaohua Lou, Binbin Ma, Yuan Zhuang, Xiang Xiao, Laurie J. Minze, Junji Xing, Zhiqiang Zhang, Xian C. Li   +7 more
doaj  

Decoding the ubiquitin-mediated pathway of arthropod disease vectors. [PDF]

PLoS ONE, 2013
Protein regulation by ubiquitin has been extensively described in model organisms. However, characterization of the ubiquitin machinery in disease vectors remains mostly unknown.
Anthony Choy, Maiara S Severo, Ruobai Sun, Thomas Girke, Joseph J Gillespie, Joao H F Pedra   +5 more
doaj   +1 more source

Spindle assembly checkpoint is sufficient for complete Cdc20 sequestering in mitotic control [PDF]

Comput Struct Biotechnol J. 2015 Apr 9;13:320-8, 2016
The spindle checkpoint assembly (SAC) ensures genome fidelity by temporarily delaying anaphase onset, until all chromosomes are properly attached to the mitotic spindle. The SAC delays mitotic progression by preventing activation of the ubiquitin ligase anaphase-promoting complex (APC/C) or cyclosome; whose activation by Cdc20 is required for sister ...
arxiv   +1 more source

Cullins 3a and 3b Assemble with Members of the Broad Complex/Tramtrack/Bric-a-Brac (BTB) Protein Family to Form Essential Ubiquitin-Protein Ligases (E3s) in Arabidopsis*

Journal of Biological Chemistry, 2005
Selective modification of proteins by ubiquitination is directed by diverse families of ubiquitin-protein ligases (or E3s). A large collection of E3s use Cullins (CULs) as scaffolds to form multisubunit E3 complexes in which the CUL binds a target ...
D. Gingerich, J. Gagne, D. Salter, H. Hellmann, M. Estelle, Ligeng Ma, R. Vierstra   +6 more
semanticscholar   +1 more source

Ubiquitin ligation to F-box protein targets by SCF–RBR E3–E3 super-assembly

Nature, 2021
E3 ligases are typically classified by hallmark domains such as RING and RBR, which are thought to specify unique catalytic mechanisms of ubiquitin transfer to recruited substrates 1 , 2 .
D. Horn-Ghetko, David T. Krist, J. R. Prabu, Kheewoong Baek, Monique P. C. Mulder, Maren Klügel, D. C. Scott, H. Ovaa, Gary Kleiger, B. Schulman   +9 more
semanticscholar   +1 more source

The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice

BMC Biology, 2022
Background Ubiquitination is a post-translational modification required for a number of physiological functions regulating protein homeostasis, such as protein degradation.
Kaori Nozawa, Yoshitaka Fujihara, Darius J. Devlin, Ricardo E. Deras, Katarzyna Kent, Irina V. Larina, Kohei Umezu, Zhifeng Yu, Courtney M. Sutton, Qiuji Ye, Laura K. Dean, Chihiro Emori, Masahito Ikawa, Thomas X. Garcia, Martin M. Matzuk   +14 more
doaj   +1 more source

E3-targetPred: Prediction of E3-Target Proteins Using Deep Latent Space Encoding [PDF]

arXiv, 2020
Understanding E3 ligase and target substrate interactions are important for cell biology and therapeutic development. However, experimental identification of E3 target relationships is not an easy task due to the labor-intensive nature of the experiments. In this article, a sequence-based E3-target prediction model is proposed for the first time.
arxiv  

A yeast cell cycle pulse generator model shows consistency with multiple oscillatory and checkpoint mutant datasets [PDF]

arXiv, 2023
The regulatory mechanisms driving progression of the yeast cell cycle appears to be comprised of an interacting network of transcription factors (TFs), cyclin-dependent kinases (CDK) and ubiquitin ligases. From a systems perspective the controlling regulatory network must produce robust periodic behavior during proliferative phases, but have the ...
arxiv