HECT E3 ubiquitin ligases – emerging insights into their biological roles and disease relevance
Journal of Cell Science, 2020 Homologous to E6AP C-terminus (HECT) E3 ubiquitin ligases play a critical role in various cellular pathways, including but not limited to protein trafficking, subcellular localization, innate immune response, viral infections, DNA damage responses and ...
Yaya Wang +4 more
semanticscholar +1 more source
The ubiquitin–protein ligase activity of Hdm2 is inhibited by nucleic acids
FEBS Letters, 2003 The proto‐oncoprotein Hdm2 is a member of the RING finger‐type family of ubiquitin–protein ligases E3. The RING finger domain is assumed to mediate the specific interaction of an E3 with its cognate ubiquitin‐conjugating enzyme E2, which catalyzes the covalent attachment of ubiquitin to substrate proteins. In addition, the RING finger domain of Hdm2 is
Laetitia K. Linares, Martin Scheffner
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A ubiquitin-protein ligase specific for type III protein substrates. [PDF]
Journal of Biological Chemistry, 1990 A previously studied species of ubiquitin-protein ligase contains specific sites for the binding of basic (Type I) and bulky hydrophobic (Type II) NH2-terminal amino acid residues of protein substrates. We now describe another enzyme that ligates ubiquitin specifically to proteins that have NH2-terminal residues other than the above two categories ...
Hannah Heller, A Hershko
openaire +2 more sources
Necdin promotes ubiquitin-dependent degradation of PIAS1 SUMO E3 ligase. [PDF]
PLoS ONE, 2014 Necdin, a pleiotropic protein that promotes differentiation and survival of mammalian neurons, is a member of MAGE (melanoma antigen) family proteins that share a highly conserved MAGE homology domain.
Ibrahim Gur +3 more
doaj +1 more source
Replication of proto-RNAs sustained by ligase-helicase cycle in oligomer world [PDF]
arXiv, 2013 A mechanism of the replication of proto-RNAs in oligomer world is proposed. The replication is carried out by a minimum cycle which is sustained by a ligase and a helicase. We expect that such a cycle actually worked in the primordial soup and can be constructed in vitro.
arxiv
Does inter-organellar proteostasis impact yeast quality and performance during beer fermentation? [PDF]
, 2019 During beer production, yeast generate ethanol that is exported to the extracellular environment where it accumulates. Depending on the initial carbohydrate concentration in the wort a high concentration of ethanol can be achieved in beer, often higher than 20% (v/v). It is noteworthy that the effects of elevated ethanol concentrations generated during
arxiv +1 more source
PepMLM: Target Sequence-Conditioned Generation of Therapeutic Peptide Binders via Span Masked Language Modeling [PDF]
arXiv, 2023 Target proteins that lack accessible binding pockets and conformational stability have posed increasing challenges for drug development. Induced proximity strategies, such as PROTACs and molecular glues, have thus gained attention as pharmacological alternatives, but still require small molecule docking at binding pockets for targeted protein ...
arxiv
Mechanistic analysis of PCNA poly-ubiquitylation by the ubiquitin protein ligases Rad18 and Rad5
EMBO Journal, 2009 Poly‐ubiquitylation is a common post‐translational modification that can impart various functions to a target protein. Several distinct mechanisms have been reported for the assembly of poly‐ubiquitin chains, involving either stepwise transfer of ...
J. L. Parker, H. Ulrich
semanticscholar +1 more source
Mechanism of cullin3 E3 ubiquitin ligase dimerization. [PDF]
PLoS ONE, 2012 Cullin E3 ligases are the largest family of ubiquitin ligases with diverse cellular functions. One of seven cullin proteins serves as a scaffold protein for the assembly of the multisubunit ubiquitin ligase complex.
Yin Yin Choo, Thilo Hagen
doaj +1 more source
Immune regulation by protein ubiquitination: roles of the E3 ligases VHL and Itch
Protein & Cell, 2018 Protein ubiquitination is an important means of post-translational modification which plays an essential role in the regulation of various aspects of leukocyte development and function.
Daisuke Aki +4 more
doaj +1 more source