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Ubiquitin-Protein Ligases - Novel Therapeutic Targets?
Current Protein and Peptide Science, 2004Intracellular protein degradation is a tightly regulated process that in many cases is controlled by protein ubiquitylation. The ubiquitin pathway is a major route by which cells not only remove normal proteins at the appropriate time but also abnormally folded normal or mutant, cytoplasmic and membrane, proteins.
Philip A, Robinson, Helen C, Ardley
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