Results 151 to 160 of about 574,104 (383)

Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1 to S phase transition and identifies a conserved family of proteins [PDF]

, 1996
Regulation of cell cycle progression occurs in part through the targeted degradation of both activating and inhibitory subunits of the cyclin-dependent kinases. During G1, CDC4, encoding a WD-40 repeat protein, and CDC34, encoding a ubiquitin-conjugating
Adams, Alison E M, Byers, Breck, Goebl, Mark G, Goetsch, Loretta, Johnson, Stephen L, Mathias, Neal, Pringle, John R, Winey, Mark   +7 more
core   +3 more sources

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

Journal of Cell Biology, 2014
PINK1 phosphorylates ubiquitin, which then binds to Parkin and activates its E3 ligase activity, leading to induction of selective autophagy of damaged mitochondria.
L. A. Kane, M. Lazarou, A. I. Fogel, Yan Li, Koji Yamano, Shireen A. Sarraf, Soojay Banerjee, R. Youle   +7 more
semanticscholar   +1 more source

Protein‐Like Polymers Targeting Keap1/Nrf2 as Therapeutics for Myocardial Infarction

Advanced Materials, EarlyView.
We describe a Keap1 targeting protein‐like polymer (PLP) which activates Nrf2, an important cytoprotective transcription factor for relieving myocardial infarction‐induced oxidative stress. This PLP increases cell survival in vitro in multiple relevant cardiac cell types and elicits pro‐reparative responses, improving cardiac function in a preclinical ...
Joshua M. Mesfin, Kendal P. Carrow, Alexander Chen, Madeline P. Hopps, JoJo J. Holm, Quincy P. Lyons, Michael B. Nguyen, Jervaughn D. Hunter, Assa Magassa, Elyse G. Wong, Kate Reimold, Sriya N. Paleti, Emily Gardner, Matthew P. Thompson, Colin G. Luo, Xiaoyu Zhang, Karen L. Christman, Nathan C. Gianneschi   +17 more
wiley   +1 more source

Autophagic Turnover of Inactive 26S Proteasomes in Yeast Is Directed by the Ubiquitin Receptor Cue5 and the Hsp42 Chaperone

Cell Reports, 2016
The autophagic clearance of 26S proteasomes (proteaphagy) is an important homeostatic mechanism within the ubiquitin system that modulates proteolytic capacity and eliminates damaged particles. Here, we define two proteaphagy routes in yeast that respond
Richard S. Marshall, Fionn McLoughlin, Richard D. Vierstra   +2 more
doaj   +1 more source

Microinjection of ubiquitin: intracellular distribution and metabolism in HeLa cells maintained under normal physiological conditions. [PDF]

, 1987
Noel G. Carlson, Martin Rechsteiner
openalex   +1 more source

A CMTM6 Nanobody Overcomes EGFR‐TKI Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Overcoming EGFR‐TKI resistance remains a critical challenge in NSCLC treatment. This study identifies CMTM6 as a key regulator of EGFR stability and demonstrates that a novel anti‐CMTM6 nanobody disrupts the CMTM6‐EGFR interaction. Targeting CMTM6 restores EGFR degradation, suppresses tumor growth, and confers therapeutic benefit in both CDX and PDX ...
Lu Xia, Jichuan Wang, Hui Xue, Haimeng Li, Qinghua Li, Sen Qin, Chunyu Yu, Yanhua Liu, Yu Gao, Lingyun Li, Sudun Guan, Enrun Zheng, Feiya Suo, Lin He, Yongsheng Wang, Wenling Han, Yongfeng Shang, Yong Geng, Luyang Sun   +18 more
wiley   +1 more source

New ubiquitin mRNA expressed during chicken spermiogenesis [PDF]

, 1987
Jovita Mezquita, Rafael Oliva, Cristóbal Mezquita   +2 more
openalex   +1 more source

Post-Translational Nuclear Protein Modification and High Vitamin-D Receptor Levels in Genetic Hypercalciuric Stone-Forming Rats

, 2016
Studies conducted on Genetic Hypercalciuric-Stone Forming (GHS) rats have shown that their excess calcium urine excretion might be caused by significantly high vitamin D receptor (VDR) levels found in key calcium-transporting tissues, since high VDR ...
Favus, MD, Murray, Goyal, Armaan
core  

The ubiquitin system: from cell signalling to disease biology and new therapeutic opportunities

Cell Death and Differentiation, 2021
R. Damgaard
semanticscholar   +1 more source