Results 171 to 180 of about 574,104 (383)
SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities [PDF]
, 1997 Traversal from G1 to S-phase in cycling cells of budding yeast is dependent on the destruction of the S-phase cyclin/CDK inhibitor SIC1. Genetic data suggest that SIC1 proteolysis is mediated by the ubiquitin pathway and requires the action of CDC34 ...
Deshaies, Raymond J. +2 more
core
Advanced Science, EarlyView.Glucocorticoid‐induced osteoporosis (GIOP) triggers osteocyte ferroptosis via SLC7A11 degradation. PSMD14 stabilizes SLC7A11 by counteracting glucocorticoid‐driven ubiquitination, preserving cystine uptake and glutathione synthesis. AAV‐mediated PSMD14 delivery or its agonist Pantethine rescues osteocyte survival and bone loss in GIOP mice.
Yifeng Shi +20 more
wiley +1 more source
Proteolysis of mitochondria in reticulocytes during maturation is ubiquitin‐dependent and is accompanied by a high rate of ATP hydrolysis [PDF]
, 1985 S. Rapoport +2 more
openalex +1 more source
Parkin uses the UPS to ship off dysfunctional mitochondria [PDF]
, 2011 Parkin is a ubiquitin E3 ligase that is implicated in familial Parkinson disease (PD). Previous studies have established its role in mitophagy, a pathway whereby dysfunctional mitochondria are targeted for autophagic degradation.
Chan, David C., Chan, Nickie C.
core
Advanced Science, EarlyView.L1CAM‐AS1 is identified as a novel H3K36me3‐guided, m6A‐modified long noncoding RNA (lncRNA) in hepatocellular carcinoma (HCC) cells. L1CAM‐AS1 stabilizes RAN protein, enhances M2 macrophages‐released CCL5‐induced nuclear import of RELA, activates the NF‐κB signaling, up‐regulates CCL2 expression and secretion from HCC cells, and enhances M2 ...
Teng Wang +6 more
wiley +1 more source
The Role of the Ubiquitin-Proteasome System and p62 in the Development of Neurodegenerative Disease [PDF]
Impulse: The Premier Undergraduate Neuroscience Journal, 2006 The ubiquitin-proteasome system (UPS) is the pathway for degradation of nuclear and cytosolic proteins that are aged, damaged, or misfolded. Malfunctions in the UPS have been implicated in a wide variety of neurodegenerative diseases. Some proteins, when
Michael G. Paine, Marie W. Wooten
doaj
Human ubiquitin genes: One member of the UbB gene subfamily is a tetrameric non‐processed pseudogene [PDF]
, 1988 Jack B. Cowland, Ove Wiborg, Jens Vuust
openalex +1 more source
Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA
Advanced Science, EarlyView.Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin +9 more
wiley +1 more source