Results 181 to 190 of about 519,123 (352)

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

Microvascular Health as a Key Determinant of Organismal Aging

Advanced Science, EarlyView.
This review spotlights the emerging field of vascular aging, providing a comprehensive and critical overview of the molecular processes and clinical manifestations of vascular dysfunction during aging. By combining basic angioscience concepts with a critical analysis of innovative pre‐clinical aging models and lifestyle interventions, it offers a ...
Mattia Cenciarini, Andrea Uccelli, Francesca Mangili, Myriam Grunewald, Simone Bersini   +4 more
wiley   +1 more source

Genes of the Ubiquitin Proteasome System Qualify as Differential Markers in Malignant Glioma of Astrocytic and Oligodendroglial Origin [PDF]

, 2022
Jerry Vriend, Thomas Klonisch
openalex   +1 more source

CircLRBA Promotes Epithelial‐Mesenchymal Transition, Immune Evasion, Chemoimmunotherapy Resistance and Metastasis Through Stabilizing Twist1

Advanced Science, EarlyView.
CircLRBA is highly expressed in breast cancer (BC) and associated with poor overall survival. Zeb1 mediated circLRBA facilitates BC cell proliferation, invasion, docetaxel (DTX) resistance and inhibits the infiltration of CD8+ T cell. CircLRBA could combine with SPOP to suppress the Twist1 ubiquitination degradation and enhances PD‐L1 transcription ...
Xiaosong Wang, Xin Yang, Lei Xing, Hang Chen, Fuming Xie, Bin Wang, Bowen Shi, Yan Yang, Junxia Chen   +8 more
wiley   +1 more source

AMP activated kinase negatively regulates hepatic Fetuin-A via p38 MAPK-C/EBPβ/E3 Ubiquitin Ligase Signaling pathway

, 2022
Vishal Kothari, Jeganathan Ramesh Babu, Suresh T. Mathews   +2 more
openalex   +1 more source

Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication

Advanced Science, EarlyView.
Wei et al. report that MPXV infection induces aerobic glycolysis, a process mediated by the viral protein I3 through lysine crotonylation at its K102 residue. The acetyltransferase MYST1 catalyzes the crotonylation of I3 to inhibit the ubiquitin‐mediated degradation of WDR26.
Pengjun Wei, Zongzheng Zhao, Ruoqi Xu, Qin Yan, Liangzi Jiang, Fuxiao Geng, Yang Gu, Tianjiao Wang, Jing Zhou, Xiao Li, Qin Yan, Chun Lu, Wan Li   +12 more
wiley   +1 more source

Bifurcate Regulation of Hematopoietic Homeostasis and Bone Osteogenesis by VHL‐HIF2α‐Controlled Adipocyte Function

Advanced Science, EarlyView.
The VHL‐HIF2α (VHL is Von Hippel‐Lindau) axis in adipocytes differentially regulates hematopoiesis and bone formation through stem cell factor (SCF) and chemerin, respectively. This hypoxia‐responsive pathway in adipocytes establishes a systemic signaling network with HSCs and MSCs to maintain tissue homeostasis, revealing a targetable axis for ...
Qian Li, Jia Li, Anshu Tang, Cong Li, Chao Zhang, Congcong Zhang, Yun‐Cai Liu   +6 more
wiley   +1 more source

SV2B Promotes the Progression of TFE3‐Rearranged Renal Cell Carcinoma by Interacting with HERC2 to Impede the Degradation of NF‐κB Subunits

Advanced Science, EarlyView.
TFE3‐rearranged renal cell carcinoma (TFE3‐RCC) lacks clearly defined diagnostic and therapeutic targets. SV2B, a TFE3 target gene, promotes TFE3‐RCC progression by activating the NF‐κB pathway. Targeted inhibition with padsevonil or Withaferin A effectively suppresses tumor progression.
Huayi Feng, Zhuang Xiong, Shaoqing Yu, Junxiao Liu, Shouqing Cao, Kan Liu, Xing Huang, Lequan Wen, Baojun Wang, Qingbo Huang, Tiejun Pan, Xu Zhang, Xin Ma, Xiubin Li   +13 more
wiley   +1 more source

ERβ/circAHNAK Axis Inhibits USP10–FMR1 Deubiquitination to Prevent m⁶A‐Mediated ADAM17 Decay and Promote Angiogenesis in Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
In clear cell renal cell carcinoma, estrogen receptor β (ERβ) upregulates circAHNAK, which competitively binds USP10 to prevent FMR1 deubiquitination, leading to FMR1 degradation. Loss of FMR1 hinders m⁶A‐dependent decay of ADAM17 mRNA, resulting in ADAM17 accumulation in tumor exosomes and enhanced angiogenesis.
Chao Xu, Sujing Zhang, Yuepeng Liu, Jingwei Lv, Yilong Cao, Yao Chen, Hao Sun, Bowei Zhang, Shengtao Dai, Jiehan Li, Xiaoling Li, Bei Shi, Qingyun Sun, Meng Zhu, Junfei Gu   +14 more
wiley   +1 more source

The <i>Shigella flexneri</i> effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic bacteria against interferon-induced ubiquitylation. [PDF]

Elife
Saavedra-Sanchez L, Dickinson MS, Apte SS, Zhang Y, De Jong M, Skavicus S, Heaton NS, Alto NM, Coers J.   +8 more
europepmc   +1 more source