Results 181 to 190 of about 305,105 (318)

Research advancements regarding the relationship between FBXO2 and malignant tumors (Review). [PDF]

Mol Med Rep
Zhang J, Yang J, Zhang X, Yuan Y, Sun S, Zhang S, He J.   +6 more
europepmc   +1 more source

Specific complex formation between yeast RAD6 and RAD18 proteins: a potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites. [PDF]

, 1994
V Bailly, John H. Lamb, Patrick Sung, Satya Prakash, Louise Prakash   +4 more
openalex   +1 more source

Ubiquitin [PDF]

, 2018
openaire   +1 more source

PSMD14‐Mediated LDHA Deubiquitination Upregulates ACLY Expression via H3K18 Lactylation to Promote Lipid Synthesis and Pancreatic Cancer Progression

Advanced Science, EarlyView.
This study investigates the expression and functional role of the deubiquitinase PSMD14 in PC, with a focus on the mechanism by which it promotes lactate accumulation–induced histone lactylation, thereby driving aberrant lipid metabolism. These findings establish that dual targeting of PSMD14 and the glycolysis–lactylation signaling axis may represent ...
Ri‐Shang Lu, Li‐Kun Ren, Xiao‐Bin Fei, Song‐Bai Liu, Yong‐Jia Gao, Jun‐Yi Hou, Chi Wang, Peng Liu, Chang‐Hao Zhu, Xing Wang, Yao‐Zhen Pan   +10 more
wiley   +1 more source

Structural and functional insights into Ubl domain-mediated regulation of SARS-CoV-2 PLpro. [PDF]

Biol Direct
Arya R, Ganesh J, Prashar V, Kumar M.
europepmc   +1 more source

Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts.

, 1991
Avram Hershko, D Ganoth, John R. Pehrson, Robert E. Palazzo, Lucie Cohen   +4 more
openalex   +1 more source

Discovering Uncharted Binding Pockets on E3 Ligases Leads to the Identification of FBW7 Allosteric Modulators

Advanced Science, EarlyView.
A computational approach to identify and characterize ligandable binding pockets on E3 ligases is presented. As a validation case, the first low‐micromolar small moleculesthat bind to the FBW7 E3 ligase are identified and confirmed to bind at the intended site.
Míriam Martínez‐Cartró, Álvaro Serrano‐Morrás, Andrea Bertran‐Mostazo, Roger Castaño‐Muñiz, Salvatore Scaffidi, Varbina Ivanova, Noémi Csorba, József Simon, Péter Ábrányi‐Balogh, Yunfeng Li, György M. Keserü, Bing Hao, Xavier Barril, Carles Galdeano   +13 more
wiley   +1 more source

A novel missense variant at the site of interaction between RLIM and E2 ubiquitin-conjugating enzymes causes Tønne-Kalscheuer syndrome. [PDF]

BMC Pediatr
Siavrienė E, Dapkūnas J, Maldžienė Ž, Mikštienė V, Petraitytė G, Preikšaitienė E.   +5 more
europepmc   +1 more source

Formation of a stable adduct between ubiquitin and the Arabidopsis ubiquitin-conjugating enzyme, AtUBC1+.

, 1993
Michael L. Sullivan, Richard D. Vierstra
openalex   +1 more source

The structure of the human gene encoding protein gene product 9.5 (PGP9.5), a neuron-specific ubiquitin C-terminal hydrolase [PDF]

, 1990
Ian N.M. Day, L J Hinks, Richard J. Thompson   +2 more
openalex   +1 more source