Results 191 to 200 of about 305,105 (318)

Disruption of NF‐κB‐Mediated Copper Homeostasis Sensitizes Breast Cancer to Cuproptosis

Advanced Science, EarlyView.
This study reveals a feedback mechanism regulating copper homeostasis, in which copper directly interacts with TAK1 to activate NF‐κB signaling, while NF‐κB transcriptionally suppresses copper transporter (CTR1) expression. These findings highlight a promising therapeutic strategy for breast cancer by combining NF‐κB inhibitors with copper chelators or
Xiaomei Zhang, Yaqing Su, Weixiong Yang, Zimin Song, Zicheng Sun, Xueji Wu, Jianwen Chen, Bing Gao, Zekang Wang, Lei Wang, Qiwei Jiang, Lang Bu, Jingting Li, Ying Lin, Wei Xie, Jie Li, Jianping Guo   +16 more
wiley   +1 more source

Heterogeneity in the structure of the ubiquitin conjugates of human alpha globin.

, 1994
Joseph R. Shaeffer
openalex   +1 more source

Immunogold localisation of ubiquitin‐protein conjugates in Sf9 insect cells [PDF]

, 1993
Péter Lőw, F J Doherty, Miklós Sass, János Kovács, R. John Mayer, Lajos László   +5 more
openalex   +1 more source

A Natural Major Module Confers the Trade‐Off between Phenotypic Mean and Plasticity of Grain Chalkiness in Rice

Advanced Science, EarlyView.
This study reveals the genetic and molecular mechanisms controlling the general trade‐off between phenotypic mean and plasticity of grain chalkiness in rice and identifies two major external drivers (high temperature and wide grain) and a natural major module (GCP6‐MPC5) that control this trade‐off.
Juncheng Zhang, Yu Du, Pengkun Xu, Luyu Zhong, Zhi Li, Wenran Zhu, Yicheng Li, Bo Cheng, Xinyuan Chang, Yawei Fan, Yibo Li   +10 more
wiley   +1 more source

Ubiquitination regulates allergic asthma by affecting immune cells and immune responses. [PDF]

Biochem Biophys Rep
Jin Z, Zhu Z, Jing X, Zeng J, Yan D.
europepmc   +1 more source

Assembly of the 26 S complex that degrades proteins ligated to ubiquitin is accompanied by the formation of ATPase activity.

, 1990
T Armon, D Ganoth, Avram Hershko
openalex   +1 more source

Purification and characterization of a ubiquitin carrier protein kinase from HeLa cells. [PDF]

, 1994
S. K. Kong, P Boon Chock
openalex   +1 more source

Post‐Translational Modifications of TOE3 Regulate Antiviral Defense in Tobacco

Advanced Science, EarlyView.
CK2αL phosphorylates TOE3 and enhances its stability, while FBXL1 promotes the ubiquitination‐degradation of TOE3 via the 26S proteasome. Compared to CK2αL‐phosphorylated TOE3, nonphosphorylated TOE3 shows a much higher affinity for FBXL1 and is more susceptible to ubiquitination‐degradation, thus facilitating viral infection. The regulatory mechanisms
Bolei Jiao, Baijun Wu, Honghui Lin, Dehui Xi   +3 more
wiley   +1 more source

Protein quality control systems in neurodegeneration - culprits, mitigators, and solutions? [PDF]

Front Neurol
Ciechanover A, Livneh I.
europepmc   +1 more source

Changes in ubiquitin and ubiquitin-protein conjugates in the CA1 neurons after transient sublethal ischemia

, 1991
Takashi Hayashi, Koji Takada, Makoto Matsuda   +2 more
openalex   +1 more source