Results 231 to 240 of about 525,256 (308)

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

Advanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan, Xinru Xi, Wei Dai, Tingfang Xiao, Yeqing Chen, Xuanyu Chen, Xiangting Ge, Chengguang Zhao, Hui Zhang, Yali Zhang, Weixi Zhang   +10 more
wiley   +1 more source

The dual role of the ubiquitin-proteasome system in photomorphogenesis. [PDF]

Essays Biochem
Zhou H, Deng XW.
europepmc   +1 more source

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source

Linear ubiquitination triggers Amph-mediated T-tubule biogenesis. [PDF]

Sci Adv
Kawaguchi K, Hama Y, Yoshikawa H, Nishino K, Morimoto K, Nakamura T, Koizumi M, Sakamaki Y, Abe K, Kakuta S, Ichimura K, Ikeda F, Kosako H, Fujita N.   +13 more
europepmc   +1 more source

Correction: BRK Targets Dok1 for Ubiquitin-Mediated Proteasomal Degradation to Promote Cell Proliferation and Migration

, 2014
The PLOS ONE Staff
openalex   +2 more sources

TOGR3, a Proteasome β4 Subunit, Orchestrates Sugar Homeostasis to Trade Off Growth and Thermotolerance in Rice

Advanced Science, EarlyView.
This study identifies a novel thermoregulatory mechanism in rice: TOGR3 partners with 26S proteasome subunits, including TT1, to drive thermoresponsive ubiquitin–proteasome activity, maintaining sugar homeostasis in stomatal regulation to balance growth and stress resistance.
Biyao Zhang, Xiaoyan Wu, Ting Xu, Feifei Guo, Xiaolu Shen, Cuiping Meng, Yanan Wang, Xue Han, Hong Zhao, Yongbiao Xue   +9 more
wiley   +1 more source

The ubiquitin-proteasome system in Alzheimer's disease: mechanism of action and current status of treatment. [PDF]

Front Aging Neurosci
Jia S, Li Q, Rui X, Qin W, Zhang W, Dou J, Zhang X.   +6 more
europepmc   +1 more source

Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization

Satoshi Kaito, Kazumasa Aoyama, Motohiko Oshima, Akiho Tsuchiya, Makiko Miyota, Masayuki Yamashita, Shuhei Koide, Yaeko Nakajima-Takagi, Hiroko Kozuka‐Hata, Masaaki Oyama, Takao Yogo, Tomohiro Yabushita, Ryoji Ito, Masaya Ueno, Atsushi Hirao, Kaoru Tohyama, Chao Li, Kimihito C. Kawabata, Kiyoshi Yamaguchi, Yoichi Furukawa, Hidetaka Kosako, Akihide Yoshimi, Susumu Goyama, Yasuhito Nannya, Seishi Ogawa, Karl Agger, Kristian Helin, Satoshi Yamazaki, Haruhiko Koseki, Noriko Doki, Yuka Harada, Hironori Harada, Atsuya Nishiyama, Makoto Nakanishi, Atsushi Iwama   +34 more
openalex   +1 more source

ubiquitin mediated proteolysis-html

, 2014
Karen Fugate
openalex   +1 more source

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

Advanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang, Shaoju Jin, Shaoying Wen, Wen Zeng, Chen Wang, Jingyu Wang, Qingyun Song, Guizhong Li, Pengzhi Yin, Yuhui Liao, Yuee Chai, Huiping Zhang, Shengchao Ma   +12 more
wiley   +1 more source