Results 191 to 200 of about 248,165 (360)

A LjBAK1-associated E3 ubiquitin ligase, LjPUB7, negatively regulates early symbiosis by targeting NFRs. [PDF]

BMC Plant Biol
Feng Y, Zou Z, Liu C, Zhang D, Wang Y, Ma Y, Cao Y, Wu P.   +7 more
europepmc   +1 more source

Characterization of Functional Domains of Cul3, an E3 Ubiquitin Ligase, Using Chimeric Analysis

, 2000
Jennifer Mitchell
openalex   +2 more sources

APC2 Cullin Protein and APC11 RING Protein Comprise the Minimal Ubiquitin Ligase Module of the Anaphase-promoting Complex [PDF]

, 2001
Zhanyun Tang, Bing Li, Rajnish Bharadwaj, Hai-Zhen Zhu, Engin Özkan, Kevin Hakala, J. Deisenhofer, Hongtao Yu   +7 more
openalex   +1 more source

Lactate Metabolic Reprogramming Mediated by CircRNA–LDHA Complex Facilitates Innate Immune Evasion of Liver Cancer

Advanced Science, EarlyView.
CircSMPD4 physically combines with lactate dehydrogenase A (LDHA) and reduces its acetylation level via SIRT2‐dependent deacetylation, thereby inhibiting chaperone‐mediated autophagy‐lysosome degradation of LDHA. Upregulating LDHA leads to increasing lactate production and extracellular export, which in turn suppresses natural killer cell cytotoxicity ...
Hao Shen, Boqiang Liu, Jing He, Weijun Zhao, Weiqi Li, Lingfeng Ma, Lidan Hou, Yi Wang, Chenqi Jin, Yushun Chang, Jie Lin, Jia Zhao, Binghan Jin, Yuanshi Tian, Xiujun Cai, Liang Shi, Yifan Wang   +16 more
wiley   +1 more source

Structural insights into the human HRD1 ubiquitin ligase complex. [PDF]

Nat Commun
Guo L, Liu G, He J, Jia X, He Y, Wang Z, Qian H.   +6 more
europepmc   +1 more source

The Cul3 Ubiquitin Ligase: An Essential Regulator of Diverse Cellular Processes

, 2000
Brittney Davidge
openalex   +2 more sources

Proteins related to the Nedd4 family of ubiquitin protein ligases interact with the L domain of Rous sarcoma virus and are required for gag budding from cells [PDF]

, 2001
Alexandra Kikonyogo, Fadila Bouamr, Marcy L. Vana, Yan Xiang, Ashok Aiyar, Carol Carter, Jonathan Leis   +6 more
openalex   +1 more source

EGFR Targeted Liposomal PROTAC Assisted With Epigenetic Regulation as an Efficient Strategy for Osimertinib‐Resistant Lung Cancer Therapy

Advanced Science, EarlyView.
In this study, an EGFR lipoSM PROTACs (GM‐protac), which can achieve efficient EGFR degradation and HDACi delivery, is developed. It is found that GM‐protac can both block EGFR‐dependent pathways and bypass the HDAC signaling pathway. Meanwhile, both display obvious tumor inhibition with negligible toxicity in EGFR‐TKI‐resistant lung cancer animal ...
Dongyuan Wang, Yajing Liu, Ying Chen, Chuan Dai, Wenzhu Hu, Jinyan Han, Zigang Li, Feng Yin, Yu Zhang, Chen Shi   +9 more
wiley   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer [PDF]

, 2002
Sabina Signoretti, Lucia Di Marcotullio, Andrea L. Richardson, Sridhar Ramaswamy, Beth Isaac, Montserrat Rué, Franco Monti, Massimo Loda, Michele Pagano   +8 more
openalex   +2 more sources