Results 191 to 200 of about 327,531 (416)

Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53 [PDF]

, 2000
Shengyun Fang, Jane Jensen, Robert L. Ludwig, Karen H. Vousden, Allan M. Weissman   +4 more
openalex   +1 more source

SUMOylation of SETD8 Promotes Tumor Growth by Methylating and Stabilizing MYC in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer (BC), MYC serves as a novel substrate of SETD8 to be methylated at lysine 412, which enhances MYC protein stability by preventing the CHIP‐mediated degradation and ultimately promotes tumor growth. SUMOylation of SETD8 leads to SETD8 stabilization and enhances MYC methylation.
Xia Zhang, Zhenxuan Chen, Xiaobo He, Jingxuan Wang, Jianliang Zhong, Yezi Zou, Xianchong Zheng, Yujie Lin, Ruhua Zhang, Tiebang Kang, Liwen Zhou, Yuanzhong Wu   +11 more
wiley   +1 more source

BMI1 induces ubiquitination and protein degradation of Nod‐like receptor family CARD domain containing 5 and suppresses human leukocyte antigen class I expression to induce immune escape in non‐small cell lung cancer

The Kaohsiung Journal of Medical Sciences, Volume 38, Issue 12, Page 1190-1202, December 2022., 2022
Abstract The Nod‐like receptor (NLR) family CARD domain containing 5 (NLRC5) has been reported as an activator of human leukocyte antigen (HLA) class I that is responsible for immune activity in cancer treatment. This work focuses on the role of BMI1 proto‐oncogene (BMI1) in the NLRC5‐HLA class I axis and in immune escape in non‐small cell lung cancer (
Zhi‐Hui Lu, Gan‐Jie Tu, Si‐Lv Fu, Kai Shang, Su‐Juan Peng, Li Chen, Xi‐Juan Gu   +6 more
wiley   +1 more source

UNC-104 transport properties are robust and independent of changes in its cargo binding [PDF]

arXiv
Cargo distribution within eukaryotic cells relies on the active transport mechanisms driven by molecular motors. Despite their critical role, the intricate relationship between motor transport properties and cargo binding - and its impact on motor distribution - remains inadequately understood.
arxiv  

Cancer Specific CAIX‐Targeting Supramolecular Lysosome‐Targeting Chimeras (Supra‐LYTAC) for Targeted Protein Degradation

Advanced Science, EarlyView.
Spatiotemporal Supra‐LYTAC formation near cancerous membrane via CAIX‐targeting is achieved. As a result of generation of Supra‐LYTAC, POI trafficking into lysosome is significantly implemented for targeted protein degradation. Abstract Recently, targeted protein degradation (TPD) strategies have emerged as a promising solution to tackle undruggable ...
Dohyun Kim, Gyeongseok Yang, Chaelyeong Lim, Gaeun Park, Jaemo Lee, Youjung Sim, Ja‐Hyoung Ryu   +6 more
wiley   +1 more source

circRNA‐MSR regulates the expression of FBXO21 to inhibit chondrocyte autophagy by targeting miR‐761 in osteoarthritis

The Kaohsiung Journal of Medical Sciences, Volume 38, Issue 12, Page 1168-1177, December 2022., 2022
Abstract Osteoarthritis (OA) is a chronic degenerative joint disease and is the most prevalent and disabling form of arthritis worldwide. Autophagy plays a vital role in OA. This study aimed to explore whether covalently closed circular RNA MSR (circRNA‐MSR) could affect the F‐box Only Protein 21 (FBXO21) expression by targeting microRNA‐761 (miR‐761),
Zhen Jia, Jia Liu, Jing Wang
wiley   +1 more source

SCFbeta-TrCP ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase [PDF]

, 2000
Amir Orian, Hedva Gonen, Beatrice Bercovich, Ifat Fajerman, Esther Eytan, Alain Israël, Frank Mercurio, Kazuhiro Iwaï, Alan L. Schwartz, Aaron Ciechanover   +9 more
openalex   +1 more source

SNORA74A Drives Self‐Renewal of Liver Cancer Stem Cells and Hepatocarcinogenesis Through Activation of Notch3 Signaling

Advanced Science, EarlyView.
Abstract Liver cancer stem cells (CSCs) account for tumor initiation, heterogeneity and therapy resistance. However, the role of small nucleolar RNAs (snoRNAs) in the regulation of liver CSCs remains largely unclear. Here, this work identifies a conserved H/ACA box snoRNA SNORA74A which is highly expressed in liver CSCs.
Ziheng Zhou, Yang Gu, Zhibin Yi, Jianyi Wang, Zhen Xiong, Hui Guo, Ying Du, Xiaoxiao Zhu, Lei He, Weizheng Ren, Yong Tian, Yanying Wang, Zusen Fan   +12 more
wiley   +1 more source

CircUCK2 regulates HECTD1‐mediated endothelial‐mesenchymal transition inhibition by interacting with FUS and protects the blood–brain barrier in ischemic stroke

The Kaohsiung Journal of Medical Sciences, Volume 39, Issue 1, Page 40-51, January 2023., 2023
Abstract Ischemic stroke (IS) has become a cerebrovascular disease of widespread concern. Overexpression of circUCK2 alleviates neuronal damage in IS. However, the specific regulatory mechanisms of circUCK2 are not fully understood. In this study, we found that circUCK2 and HECT domain E3 ubiquitin ligase 1 (HECTD1) were downregulated in IS models in ...
Jun‐Hong Zhuang, Huan‐Xiong Chen, Ning Gao, Rong‐Dao Sun, Cheng‐Ye Xiao, De‐Hua Zeng, Zheng‐Tao Yu, Jun Peng, Ying Xia   +8 more
wiley   +1 more source

Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4 [PDF]

, 2000
Corina N. Jolliffe, Kieran F. Harvey, Bryan P. Haines, Gayathri Parasivam, Sharad Kumar   +4 more
openalex   +1 more source