Results 111 to 120 of about 39,029 (256)
Advanced Science, EarlyView.. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li +15 more
wiley +1 more source
Cell Reports, 2017 Activation of the main DNA interstrand crosslink repair pathway in higher eukaryotes requires mono-ubiquitination of FANCI and FANCD2 by FANCL, the E3 ligase subunit of the Fanconi anemia core complex. FANCI and FANCD2 form a stable complex; however, the
Paolo Swuec +8 more
doaj +1 more source
The Role of Ubiquitination in Regulation of Innate Immune Signaling
, 2015 Ubiquitination, also denoted ubiquitylation, is a posttranslational modification that has been implicated in the regulation of both innate and adaptive immune responses. Ubiquitination plays crucial roles in innate immune signaling by ensuring the proper
Shengfeng Wan +7 more
core +1 more source
Advanced Science, EarlyView.ABSTRACT Current clinical approaches for knee cartilage repair are often limited by hypertrophy and fibrosis in the regenerated tissues. A decellularized tissue‐engineered hyaline cartilage graft (dLhCG), composed of a type II collagen‐based extracellular matrix, has been developed to overcome this limitation.
Zhen Zhang +16 more
wiley +1 more source
The Expanding Universe of Ubiquitin and Ubiquitin-Like Modifiers [PDF]
Plant Physiology, 2012 The post-translation addition of ubiquitin (Ub) and structurally related polypeptide modifiers to other intracellular constituents is now known to be an important intermediate driving a wide assortment of metabolic and regulatory processes in plants. Although the most common targets are other proteins, conjugation of specific modifiers to lipids and ...
openaire +2 more sources
Advanced Science, EarlyView.Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li +8 more
wiley +1 more source
Presynaptic protein ubiquitination and synaptic transmission [PDF]
, 2018 Ubiquitination of a target protein is an important post-translational modification. There is evidence for the involvement of ubiquitination of presynaptic proteins in synaptic transmission.
Vojnovic, Dijana
core +1 more source
, 2007 Cette thèse a été consacrée à l étude de la régulation par ubiquitination d une protéine de signalisation cellulaire, la GTPase Rac1. J ai montré que l ubiquitination dégradative de Rac1 affecte peu son variant d épissage Rac1b, et qu elle requiert l ...
GACON, Gérard, VISVIKIS, Orane
core
TED1 Promotes the Assembly of SCFD3‐D14‐D53 to Reinforce Strigolactone Signaling in Rice
Advanced Science, EarlyView.This study identifies TED1 as a positive regulator of strigolactones (SL) signaling in rice. The ted1 mutants display dwarfism and increased tillering with significantly reduced SLs sensitivity. Through its longer C‐terminal region, TED1 interacts with D53 and D14 to promote the assembly of SCFD3‐D14‐D53, thereby facilitating the efficient ...
Sheng Luo +22 more
wiley +1 more source
Molecular Mechanisms of TRAF6 Ubiquitination and Activation [PDF]
, 2009 The Tumor Necrosis Factor (TNF) Receptor Associated Factor 6 (TRAF6) is an intracellular signal transducers, being responsible for mediating many of the activation events initiated by TNF receptor (TNFR) and Toll-like/Interleukin-1 and 18 receptor (TIR ...
Wang, Zhi Qiang Kent
core +1 more source