Results 91 to 100 of about 39,029 (256)

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Insights into ubiquitinome dynamics in the host‒pathogen interplay during Francisella novicida infection

Cell Communication and Signaling
Ubiquitination functions as an important posttranslational modification for orchestrating inflammatory immune responses and cell death during pathogenic infection.
Luyu Yang, Yanfeng Li, Qingqing Xie, Tao Xu, Xiaopeng Qi   +4 more
doaj   +1 more source

Impact of High Glucose and Proteasome Inhibitor MG132 on Histone H2A and H2B Ubiquitination in Rat Glomerular Mesangial Cells

Journal of Diabetes Research, 2013
Background. Hyperglycemia plays a pivotal role in the development of diabetic nephropathy (DN) and may be related to epigenetic metabolic memory.
Chenlin Gao, Guo Chen, Li Liu, Xia Li, Jianhua He, Lan Jiang, Jianhua Zhu, Yong Xu   +7 more
doaj   +1 more source

Quantitative proteomics reveals extensive lysine ubiquitination and transcription factor stability states in Arabidopsis [PDF]

Protein activity, abundance, and stability can be regulated by post-translational modification including ubiquitination. Ubiquitination is conserved among eukaryotes and plays a central role in modulating cellular function; yet, we lack comprehensive ...
Pu, Yunting, Clark, Natalie M., Song, Gaoyuan, Montes, Christian, Olatunji, Damilola, Walley, Justin W., Malik, Shikha, Kelley, Dior, Ji, Chonghui   +8 more
core  

Ciliary/Flagellar Protein Ubiquitination

, 2015
Cilia/flagella are conserved eukaryotic organelles that play an important role in the control of cell motility and detection of environmental cues. However, the molecular mechanisms underlying ciliary/flagellar assembly, maintenance, disassembly, and ...
Huan Long, Qiyu Wang, Kaiyao Huang
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

The Ligation Systems for Ubiquitin and Ubiquitin-like Proteins

Molecules and Cells, 1998
Ubiquitin (Ub) is a highly conserved small protein present universally in eukaryotic cells, which is covalently attached to substrate proteins by a cascade system, consisting of activating (E1), conjugating (E2), and/or ligating (E3) enzymes. The modification of cellular proteins with Ub targets them for degradation by a large multisubunit protease ...
K, Tanaka, T, Suzuki, T, Chiba
openaire   +2 more sources

The role of ubiquitination in health and disease

MedComm
Ubiquitination is an enzymatic process characterized by the covalent attachment of ubiquitin to target proteins, thereby modulating their degradation, transportation, and signal transduction.
Yan Liao, Wangzheqi Zhang, Yang Liu, Chenglong Zhu, Zui Zou   +4 more
doaj   +1 more source

Bidirectional regulation of the ubiquitin-RNA modification axis in cancer

Frontiers in Oncology
RNA modifications, dynamically regulated by RNA-modifying proteins (RMPs) acting as “writers”, “erasers”, and “readers”, play pivotal roles in governing gene expression and cellular fate.
Kailang Li, Kailang Li, Lingling Bao, Lingling Bao, Bitao Jiang, Bitao Jiang, Xiaofeng Jin   +6 more
doaj   +1 more source

Insights into non-proteinaceous ubiquitination [PDF]

Ubiquitination plays a key role in the regulation of numerous diverse cellular functions. This process involves the covalent attachment of ubiquitin to protein substrates by a cascade of enzymes.
Huang, Danny, Dearlove, Emily
core   +1 more source