FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Mastermind-Like 1 Is Ubiquitinated: Functional Consequences for Notch Signaling.
PLoS ONE, 2015 Early studies demonstrated the involvement of ubiquitination of the Notch intracellular domain for rapid turnover of the transcriptional complex at Notch target genes. It was shown that this ubiquitination was promoted by the co-activator Mastermind like
Mozhgan Farshbaf +7 more
doaj +1 more source
USP15 regulates dynamic protein-protein interactions of the spliceosome through deubiquitination of PRP31. [PDF]
, 2017 Post-translational modifications contribute to the spliceosome dynamics by facilitating the physical rearrangements of the spliceosome. Here, we report USP15, a deubiquitinating enzyme, as a regulator of protein-protein interactions for the spliceosome ...
Das, Tanuza +6 more
core +1 more source
Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction
Advanced Healthcare Materials, EarlyView.Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang +4 more
wiley +1 more source
Ubiquitination in osteosarcoma: unveiling the impact on cell biology and therapeutic strategies
Cancer Biology & MedicineUbiquitination, a multifaceted post-translational modification, regulates protein function, degradation, and gene expression. The pivotal role of ubiquitination in the pathogenesis and progression of cancer, including colorectal, breast, and liver cancer,
Jianlin Shen +5 more
doaj +1 more source
Research Progress on the Mechanism for the Effect of Ubiquitination on Meat Quality [PDF]
Shipin KexueMeat quality is closely related to consumer experience and the benefits of deep processing enterprises, and it is influenced by diverse and complex factors.
WANG Mengxue, LIU Jitong, LI Jiqiang, ZHANG Lei, LIU Chenyue, ZHAO Wenyue, CHENG Haijian, TONG Lin, MAO Yanwei, ZHANG Yimin
doaj +1 more source
SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities [PDF]
, 1997 Traversal from G1 to S-phase in cycling cells of budding yeast is dependent on the destruction of the S-phase cyclin/CDK inhibitor SIC1. Genetic data suggest that SIC1 proteolysis is mediated by the ubiquitin pathway and requires the action of CDC34 ...
Deshaies, Raymond J. +2 more
core
The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex [PDF]
, 2015 The MAGE (Melanoma-associated antigen) protein family members are structurally related to each other by a MAGEhomology domain comprised of 2 winged helix motifs WH/A and WH/B. This family specifically evolved in placental mammals although single homologs
Alan R Lehmann +11 more
core +3 more sources
Regional and age-dependent changes in ubiquitination in cellular and mouse models of Spinocerebellar ataxia type 3 [PDF]
, 2023 Haiyang Luo +3 more
openalex +1 more source
Advanced Materials Technologies, EarlyView.This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang +4 more
wiley +1 more source