Results 251 to 260 of about 308,731 (375)

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

Advanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li, Xueqi He, Xinyuan Hao, Yu Zhang, Xin Zhao, Shuang Wang, Zhenru Wang, Haonan Du, Hongda Li, Lian Yi, Zhimin Du, Weijie Du   +11 more
wiley   +1 more source

Collision-induced ribosome degradation driven by ribosome competition and translational perturbations. [PDF]

Nat Commun
Li S, Shounai O, Kato M, Ikeuchi K, Inada T.   +4 more
europepmc   +1 more source

Single-cell and multi-omics analysis identifies TRIM9 as a key ubiquitination regulator in pancreatic cancer

Liang Chen, Xiaomei Ying, Chenfeng Ma, Qikai Tang, Shuai Chen   +4 more
openalex   +1 more source

SARS-CoV-2/COVID-19 and its relationship with NOD2 and ubiquitination

, 2022
Edgardo Guzman Rivera, Asha Patnaik, Joann Salvemini, Sanjeev Jain, Katherine Lee, Daniel Lozeau, Qingping Yao   +6 more
openalex   +2 more sources

Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion

Advanced Science, EarlyView.
FUT8‐mediated core fucosylation of CD47 at N111 blocks SMURF1 binding and reduces CD47 ubiquitination and degradation. Blocking N111 glycosylation reduces CD47 expression and promotes macrophage phagocytosis of tumor cells. Furthermore, ablating CD47 core fucosylation boosts CD103+ dendritic cells (DCs) infiltration, increases natural killer (NK) cell ...
Yuting Cao, Siyuan Chai, Mingyang Li, Xiaoming Chen, Jiating Hu, Bingyi Lin, Liming Wu, Wen Yi, Qiang Zhu   +8 more
wiley   +1 more source

STING single amino acid polymorphisms modulate iridovirus immune evasion and pathogenicity spectrum. [PDF]

Proc Natl Acad Sci U S A
Qin X, Liang M, Pan W, Zhan Z, Li C, You Y, Weng S, He J, Guo C.   +8 more
europepmc   +1 more source

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

Advanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li, Shimin Jiang, Qi Jin, Peng Qu, Yingjie Guo, Xushan Lan, Xinyu Li, Cuiting Sun, Sinan Ai, Xin Li, Weiliang Sun, Jing Guo, Wenge Li, Liang Peng, Lihong Liu   +14 more
wiley   +1 more source

Interplay between ubiquitination and ADP-ribosylation and the case of dual modification ADPr-Ub. [PDF]

Essays Biochem
Zhu K, Chatrin C, Smith R, Ahel D, Ahel I.   +4 more
europepmc   +1 more source

Stk38 protein kinase preferentially inhibits TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages [PDF]

, 2015
Mingyue Wen, Xianwei Ma, Hong Cheng, Wei Jiang, Xiongfei Xu, Yi Zhang, Yan Zhang, Zhenhong Guo, Yizhi Yu, Hongmei Xu, Cheng Qian, Xuetao Cao, Huazhang An   +12 more
openalex   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source