Results 261 to 270 of about 278,733 (404)

Regulation of placental development and function by ubiquitination. [PDF]

Mol Med
Wang X, Li X, Yuan S, Gu Z, An Z, Xu Q, Cao B, Song Y, Tang C.   +8 more
europepmc   +1 more source

Fn14 Controls the SIRT2‐Mediated Deacetylation of Slug to Inhibit the Metastasis of Epithelial Ovarian Cancer

Advanced Science, EarlyView.
It is reported that Fn14 inhibited EOC metastasis by regulating Slug‐mediated EMT. Furthermore, Fn14 altered the subcellular localization of SIRT2 by interacting with SIRT2, leading to reduced SIRT2 shuttling into the nucleus and subsequently promoting the acetylated degradation of Slug.
Anyue Wu, Shengze Li, Chunyang Feng, Ruiju He, Ruolan Wu, Zhijun Hu, Jinhua Huang, Wenjing Wang, Lei Huang, Lihua Qiu   +9 more
wiley   +1 more source

Src-catalyzed Phosphorylation of c-Cbl Leads to the Interdependent Ubiquitination of Both Proteins [PDF]

, 2001
Masahiro Yokouchi, Takeshi Kondo, Archana Sanjay, Adam Houghton, Akihiko Yoshimura, Seturo Komiya, Hui Zhang, Roland Baron   +7 more
openalex   +1 more source

N-glycosylated LTβR increases the Th17/Treg cell ratio in liver cancer by blocking RORC ubiquitination and FOXP3 transcription. [PDF]

Cell Death Dis
Pan B, Yao Y, Wu H, Ye D, Zhang Z, Zhang X, Wang X, Tang N.   +7 more
europepmc   +1 more source

HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis

Advanced Science, EarlyView.
Glioblastoma (GBM) growth relies on glutamine synthetase (GS), which is stabilized by histone deacetylase 6 (HDAC6) and deubiquitinated by ubiquitin‐specific peptidase 9, X‐linked (USP9X). HDAC6 promotes GS deacetylation, while USP9X removes its K48‐linked polyubiquitination, enhancing GS stability.
Go Woon Kim, Minhae Cha, Hien Thi My Ong, Jung Yoo, Yu Hyun Jeon, Sang Wu Lee, Soo Yeon Oh, Min‐Jung Kang, Youngsoo Kim, So Hee Kwon   +9 more
wiley   +1 more source

Ubiquitination is essential for human cytomegalovirus US11-mediated dislocation of MHC class I molecules from the endoplasmic reticulum to the cytosol [PDF]

, 2001
Marjolein Kikkert, Gerco Hassink, Martine T. Barel, Christian Hirsch, F.J. van der Wal, Emmanuel J. H. J. Wiertz   +5 more
openalex   +1 more source

Brassinosteroid Signaling Dynamics: Ubiquitination-Dependent Regulation of Core Signaling Components. [PDF]

Int J Mol Sci
Qiu R, Zhou Y, Mao J.
europepmc   +1 more source

PP1A Modulates the Efficacy of Lenvatinib Plus ICIs Therapy by Inhibiting Ferroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
PP1A dephosphorylates Keap1 at the S104 site, stabilizing and promoting the nuclear translocation of Nrf2, which upregulates the expression of antioxidant genes and PD‐L1. This leads to suppressed ferroptosis and enhanced immune evasion, thereby improving the efficacy of TKI and ICI combination therapy.
Jitong Zhou, Meng Gao, Shikun Zhang, Wing‐Wa Guo, Wenzhi He, Minghe Zhang, Xi Chen, Cairang Dongzhi, Xiaomian Li, Yufeng Yuan, Weijie Ma   +10 more
wiley   +1 more source

Regulation of Ubiquitination and Degradation of p53 in Unstressed Cells through C-terminal Phosphorylation [PDF]

, 2001
Mikhail V. Chernov, Lora Jh Bean, Natalia Lerner, George R. Stark   +3 more
openalex   +1 more source

The Role of Ubiquitination on Macrophages in Cardiovascular Diseases and Targeted Treatment. [PDF]

Int J Mol Sci
Wang L, Zhang Y, Yue J, Zhou R.
europepmc   +1 more source