Results 271 to 280 of about 187,561 (340)

The Role of Ubiquitination on Macrophages in Cardiovascular Diseases and Targeted Treatment. [PDF]

Int J Mol Sci
Wang L, Zhang Y, Yue J, Zhou R.
europepmc   +1 more source

TRIB3 suppresses milk fatty acids metabolism by inhibiting p‐AKT/PPARG signaling in goat mammary epithelial cells

Animal Research and One Health, EarlyView.
In this study, it revealed that TRIB3 could mediate the transcriptional activity of PPARG, inhibit the phosphorylation of akt, and reduce the expression of lipid metabolism‐related genes, thus inhibiting TAG synthesis and affecting fatty acid composition.
Xinglong Gong, Tan Pan, Tiantian Xiong, Yifan Zhu, Juan J. Loor, Chengming Han, Yifan Li, Huan Lei, Jun Luo, Cong Li   +9 more
wiley   +1 more source

20-Hydroxyecdysone Modulates Bmp53-Mediated Apoptosis Regulation by Suppressing Mdm2-like-Dependent Ubiquitination in Silkworm, <i>Bombyx mori</i>. [PDF]

Insects
Wang M, Han D, Xiang L, Wang J, Luo B, Shen X.   +5 more
europepmc   +1 more source

Loss of TRIM21 drives UVB‐induced systemic inflammation by regulating DNA‐sensing pathways

Arthritis &Rheumatology, Accepted Article.
Background Patients with systemic lupus erythematosus (SLE) experience photosensitivity, with exposure to ultraviolet light B (UVB) driving lupus flares and triggering symptoms like joint pain, fatigue, and cutaneous lesions. Although the mechanism(s) linking UVB exposure to systemic effects are unclear, type I interferons (IFNs) are known to play a ...
Gantsetseg Tumurkhuu, Graziela Perri, Richard Moore, Lihong Huo, Arati Naveen Kumar, Richard Ainsworth, Trinitee Oliver, Gabriela de los Santos, David Gibb, Jessica Carriere, Jeong Min Yu, Rachel Abuav, Lindsy Forbess, Daniel J. Wallace, Mariko Ishimori, Wonwoo Shon, Christian Stehlik, Caroline A. Jefferies   +17 more
wiley   +1 more source

Midnolin Ubiquitination is Required for its Proteasome-Mediated Degradation. [PDF]

MedComm (2020)
He J, Lai T, Zhao Y, Yang H, Lei Z, Zhou L, Li N, He Y, Zhou W, Wu Y.   +9 more
europepmc   +1 more source

Ubiquitin C‐Terminal Hydrolase L1 (UCHL1), Beyond Hydrolysis

BioEssays, EarlyView.
UCHL1 is a neuron‐enriched component of the ubiquitin‐proteasome system. This review debates the biological relevance of its biochemical roles: limited DUB activity, potential ligase function, and mono‐ubiquitin stabilization. We emphasize the need to clarify the mechanisms and identify natural substrates for each function to understand their role in ...
Anwar Bdarneh, Inbal Maniv, Michael H. Glickman   +2 more
wiley   +1 more source

Degradation of voltage-gated calcium channels: mechanisms and applications in neurological and cardiovascular diseases. [PDF]

Cell Commun Signal
Liu L, Zhou Y, Liao P, Soong TW, Hu Z.
europepmc   +1 more source

Analysis of the Adenovirus E1B-55K-Anchored Proteome Reveals Its Link to Ubiquitination Machinery

, 2002
Josephine N. Harada, Anna Shevchenko, Andriy Shevchenko, David C. Pallas, Arnold Berk   +4 more
openalex   +1 more source

Dynamic protein interactions probed by NMR spectroscopy

Bulletin of the Korean Chemical Society, EarlyView.
Abstract Dynamic protein–protein interactions are essential for diverse cellular processes but often evade structural characterization due to their transient, heterogeneous, and disordered nature. This review focuses on how nuclear magnetic resonance (NMR) spectroscopy can provide detailed, residue‐level insights into these complex interactions.
Jaeseok Lee, Jung Ho Lee
wiley   +1 more source

Ubiquitination-targeted therapies improve BMD iPSC myogenic cell engraftment and dystrophin expression <i>in vivo</i>. [PDF]

Mol Ther Methods Clin Dev
Liu M, Chatterjee S, Wu J, Kashaniasl Z, Kumar A, Lin C, Darabi R.   +6 more
europepmc   +1 more source