Results 331 to 340 of about 278,733 (404)

Mitochondria and Endoplasmic Reticulum Contact Site as a Regulator of Proteostatic Stress Responses in Neurodegenerative Diseases

BioEssays, EarlyView.
Recent findings indicate that mitochondria‐associated membranes (MAMs), where the endoplasmic reticulum directly contacts the mitochondria, are a novel microdomain essential for cellular homeostasis, including proteostasis. We summarize the disruption of protein homeostasis and MAM alteration in neurodegenerative diseases, then discuss challenges and ...
Seiji Watanabe, Koji Yamanaka
wiley   +1 more source

F-box protein FBXO32 ubiquitinates and stabilizes D-type cyclins to drive cancer progression. [PDF]

Nat Commun
Li F, Yu H, Zhang Y, Ma Y, Chen X, Zhang J, Sun L, Guo R, Wu Y, Zheng P, Wang X, Bie P, He F, Zhang L, Xie C, Xiong H.   +15 more
europepmc   +1 more source

Annexin, a Protein for All Seasons: From Calcium Dependent Membrane Metabolism to RNA Recognition

BioEssays, EarlyView.
Annexins are an important protein family traditionally well known to bind to phospholipids and to interact with various proteins in a calcium dependent way. More recently, it has been established that a feature common to the family is also to bind to RNA having a role in translation. In bies70019 article, Vedeler et al.
Anni Vedeler, Gian Gaetano Tartaglia, Annalisa Pastore   +2 more
wiley   +1 more source

Regulation of Arabidopsis brassinosteroid receptor BRI1 endocytosis and degradation by plant U-box PUB12/PUB13-mediated ubiquitination

Proceedings of the National Academy of Sciences of the United States of America, 2018
Jinggeng Zhou, Derui Liu, Ping Wang, Xiyu Ma, Wenwei Lin, Sixue Chen, K. Mishev, Dongping Lu, Rahul Kumar, I. Vanhoutte, Xiangzong Meng, P. He, E. Russinova, Libo Shan   +13 more
semanticscholar   +1 more source

Nonproteolytic ubiquitination regulates chromatin occupancy by the NCoR/SMRT/HDAC3 corepressor complex in MCF-7 breast cancer cells. [PDF]

Proc Natl Acad Sci U S A
Ferrero G, Cardamone MD, Luca F, Bourk E, Ricci L, Liu W, Gao Y, Burrone G, Muhammad A, Chan S, Smith E, Fan TC, Cutrupi S, Garcia-Bassets I, De Bortoli M, Rosenfeld MG, Perissi V.   +16 more
europepmc   +1 more source

X‐ray controlled release strategy in cancer therapy

BMEMat, EarlyView.
A comprehensive review on the design principles and current strategies of X‐ray stimulated release systems in cancer therapy, focusing on the X‐ray responsive functional groups and materials as well as discussing the advantages and current challenges of X‐ray controlled release systems in cancer therapy.
Yiling Ruan, Hongxiang Huang, Huihui Liu, Jinglang Gong, Changjun Li, Xiaolian Sun   +5 more
wiley   +1 more source

Ubiquitin-conjugating enzyme UBE2N modulates proteostasis in immunoproteasome-positive acute myeloid leukemia. [PDF]

J Clin Invest
Ishikawa C, Barreyro L, Sampson AM, Hueneman KM, Choi K, Philbrook SY, Choi I, Bolanos LC, Wunderlich M, Volk AG, Watowich SS, Greis KD, Starczynowski DT.   +12 more
europepmc   +1 more source

Blocking ITGA5 potentiates the efficacy of anti‐PD‐1 therapy on glioblastoma by remodeling tumor‐associated macrophages

Cancer Communications, EarlyView.
Abstract Background Glioblastoma (GBM) is largely refractory to antibodies against programmed cell death 1 (anti‐PD‐1) therapy. Fully understanding the cellular heterogeneity and immune adaptations in response to anti‐PD‐1 therapy is necessary to design more effective immunotherapies for GBM.
Rongrong Zhao, Ziwen Pan, Jiawei Qiu, Boyan Li, Yanhua Qi, Zijie Gao, Wei Qiu, Weijie Tang, Xiaofan Guo, Lin Deng, Gang Li, Hao Xue   +11 more
wiley   +1 more source

The role of ubiquitination and deubiquitination in the pathogenesis of non-alcoholic fatty liver disease. [PDF]

Front Immunol
Zhang L, Liu S, Zhao Q, Liu X, Zhang Q, Liu M, Zhao W.   +6 more
europepmc   +1 more source

Hijacking the MDM2 E3 Ligase with novel BRD4‐Targeting PROTACs in Pancreatic Cancer Cells

ChemBioChem, Accepted Article.
The phenotypic effect induced by a Proteolysis‐Targeting Chimera (PROTAC) can depend on several factors, including the E3 ligase recruited. For the discovery of a first‐in‐class PROTAC for a target of interest, the E3 ligases commonly hijacked remain the Von Hippel‐Lindau (VHL) and Cereblon (CRBN) since potent and accessible ligands are readily ...
Mihaela Ficu, Dan Niculescu-Duvaz, Mohammed Aljarah, Caroline Springer, Christopher S. Kershaw   +4 more
wiley   +1 more source