Results 1 to 10 of about 117,949 (359)
The dynamics of linear polyubiquitin
Science Advances, 2020 A new efficient method for SAXS-driven simulations allows researchers to explain the dynamics of linear polyubiquitin. Polyubiquitin chains are flexible multidomain proteins, whose conformational dynamics enable them to regulate multiple biological ...
Alexander Jussupow +8 more
semanticscholar +1 more source
In the family with ubiquitin [PDF]
EMBO reports, 2011 The Cold Spring Harbor meeting on ‘The Ubiquitin family’, held in May 2011, brought together scientists from a wide range of fields, all under the common umbrella of ubiquitin and ubiquitin‐like protein structure, function and regulation.
Alexandru, Gabriela +2 more
openaire +4 more sources
The CaVβ Subunit Protects the I-II Loop of the Voltage-gated Calcium Channel CaV2.2 from Proteasomal Degradation but Not Oligoubiquitination. [PDF]
, 2016 CaVβ subunits interact with the voltage-gated calcium channel CaV2.2 on a site in the intracellular loop between domains I and II (the I-II loop). This interaction influences the biophysical properties of the channel and leads to an increase in its ...
Dolphin, AC, Page, KM, Rothwell, SW
core +1 more source
Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains
Cell Reports, 2016 Myosin VI is critical for cargo trafficking and sorting during early endocytosis and autophagosome maturation, and abnormalities in these processes are linked to cancers, neurodegeneration, deafness, and hypertropic cardiomyopathy.
Fahu He +9 more
doaj +1 more source
A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation. [PDF]
, 2015 Ubiquitination is of great importance as the post-translational modification of proteins with ubiquitin, or ubiquitin chains, facilitates a number of vital cellular processes.
Caddick, S +4 more
core +1 more source
Molecular Plant-Microbe Interactions, 2009 Plant responses against pathogens cause up- and downward shifts in gene expression. To identify differentially expressed genes in a plant-virus interaction, susceptible tomato plants were inoculated with the potyvirus Pepper yellow mosaic virus (PepYMV ...
Poliane Alfenas-Zerbini +5 more
doaj +1 more source
Analysis of polyubiquitin conjugates reveals that the Rpn10 substrate receptor contributes to the turnover of multiple proteasome targets [PDF]
, 2005 The polyubiquitin receptor Rpn10 targets ubiquitylated Sic1 to the 26S proteasome for degradation. In contrast, turnover of at least one ubiquitin-proteasome system (UPS) substrate, CPY*, is impervious to deletion of RPN10.
Deshaies, Raymond J. +4 more
core +1 more source
Experimental and Molecular Medicine, 2018 Experimental & molecular medicine Researchers may have found a new target for treatment of multiple myeloma (MM), a common type of blood cancer.
Lili Zhou +7 more
doaj +1 more source
Optineurin functions for optimal immunity [PDF]
, 2018 Optineurin (OPTN) was identified 20 years ago in a yeast-two-hybrid screen with a viral protein known to inhibit the cytolytic effects of tumor necrosis factor.
Slowicka, Karolina, van Loo, Geert
core +1 more source
Nature Communications, 2020 Ubiquitin mediated signaling contributes critically to host cell defenses during pathogen infection. Many pathogens manipulate the ubiquitin system to evade these defenses.
Jason M. Berk +10 more
semanticscholar +1 more source