Results 201 to 210 of about 117,989 (312)

Targeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias

Advanced Science, EarlyView.
Mass spectrometry‐based proteomics identify DESI2 as a novel component of the JAK2‐V617F complex, which associates with and stabilizes mutant JAK2 through deSUMOylation and deubiquitination, therefore promoting JAK2 mutant cell growth and MPN disease onset in vivo.
Husheng Mei, Wuqiang Wen, Wenjun Zhang, Shujing Zhang, Ting Sun, Guiming Li, Jing Zhang, Shuang Qi, Jie Zhou, Bing Li, Yunshuo Zhao, Xiaotong Chen, Bowen Li, Yiying Xue, Wang Lu, Yanli Sun, Jingyao Wang, Hengyue Shan, Shengzhe Zhang, Yushan Huang, Yisa Chen, Wenchao Wang, Qingsong Liu, Wenchao Lu, Li Tan, Yi Ding, Jianfei Fu, Jun Long, Lei Zhang, Baobing Zhao, Aibin Liang, Baishan Jiang, Jing Yang   +32 more
wiley   +1 more source

A Quinoline Derivative HZ-6d Induces Antiviral Activity Against Hepatitis C Virus Via Apoptosis-Mediated Cytotoxicity. [PDF]

Kobe J Med Sci
Suwardana GNR, Rhamadianti AF, Abe T, Deng L, Matsui C, Yasui M, Takeda N, Yamada T, Ueda M, Shoji I.   +9 more
europepmc   +1 more source

Non-radioactive in vitro PINK1 Kinase Assays Using Ubiquitin or Parkin as Substrate

, 2016
Fabienne C. Fiesel, Roman Hudec, Wolfdieter Springer   +2 more
openalex   +2 more sources

ubiquitin

Citation: 'ubiquitin' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13767 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Cytokinin Growth Responses in Arabidopsis Involve the 26S Proteasome Subunit RPN12 Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.010381.

The Plant Cell Online, 2002
Jan A. Smalle, J. Kurepa, Peizhen Yang, E. Babiychuk, S. Kushnir, Adam M. Durski, R. Vierstra   +6 more
semanticscholar   +1 more source

EGR Proteins Mediate Interferon‐Independent Anti‐HSV‐1 Responses Through Viral and Host Targets

Advanced Science, EarlyView.
Early antiviral responses are typically mediated by interferons. However, during HSV‐1 infection, host early growth response (Egr) genes, which are not interferon‐stimulated genes, are quickly induced by viral protein ICP0. EGR proteins, in turn, suppress viral lytic infection by activating viral latency‐associated (LAT) and host immune regulatory ...
Shuaishuai Wang, Fujun Hou, Xunuo Jin, Yuhang Xiang, Dongli Pan   +4 more
wiley   +1 more source

Statins attenuate PD-L1 sorting to small extracellular vesicles dependent on ubiquitin-like 3 modification. [PDF]

Sci Rep
Ageta H, Shimada Y, Nagaoka T, Takenaka K, Yoshioka Y, Konno K, Amemiya R, Nagase K, Hitachi K, Onouchi T, Watanabe M, Ochiya T, Tsuchida K.   +12 more
europepmc   +1 more source

2P066 Folding dynamics of ubiquitin after rapid mixing detected by single molecule fluorescence spectroscopy(01C. Protein: Property,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014))

, 2014
Masataka Saito, Eric Chen, Po‐Ting Chen, Rita P.‐Y. Chen, Kiyoto Kamagata, Hiroyuki Oikawa, Satoshi Takahashi   +6 more
openalex   +2 more sources

Brd4 BD1 Domain Antagonism of MS436 Preserves Blood‐Brain Barrier Integrity via Rnf43/β‐Catenin Signaling Pathway

Advanced Science, EarlyView.
MS436 competitively binds to the BD1 domain of Brd4, thereby suppressing Brd4 induced degradation of tight junction proteins via the Rnf43‐Fzd4‐β‐catenin signaling pathway. Consequently, this attenuation of degradation reduces blood‐brain barrier leakage, leading to an improved overall prognosis after stroke.
Chenxiao Li, Xiaochen Zhang, Jiangwei Xia, Shuang Liu, Yushan Du, Sihan Li, Shukui Zhang, Yong Zhang, Fen Ji, Jianwei Jiao, Jingjing Zhang   +10 more
wiley   +1 more source