Results 201 to 210 of about 33,989 (317)

Editorial: Aging and the social-emotional brain. [PDF]

Front Aging Neurosci
Soria-Gómez E, Piriz J, Torres-Alemán I.   +2 more
europepmc   +1 more source

Complete reconstitution of conjugation and subsequent degradation of the tumor suppressor protein p53 by purified components of the ubiquitin proteolytic system [PDF]

, 1994
Dganit Shkedy, Hedva Gonen, Beatrice Bercovich, Aaron Ciechanover   +3 more
openalex   +1 more source

The MdHB7L–MdICE1L–MdHOS1 Module Fine‐Tunes Apple Cold Response via CBF‐Dependent and CBF‐Independent Pathways

Advanced Science, EarlyView.
In early cold response, MdICE1L utilizes MdHB7L as a cofactor to facilitate the transcriptional activation of MdCBFs, thereby activating cold signaling rapidly and strongly. Subsequently, MdICE1L is degraded by MdHOS1. Meanwhile, MdHB7L is released and accumulates.
Jie Yang, Na Li, Ming Li, Ran Yi, Lina Qiu, Kangning Wang, Shuang Zhao, Fengwang Ma, Ke Mao   +8 more
wiley   +1 more source

FBXW2 inhibits the progression of gastric cancer via promoting β-catenin ubiquitylation. [PDF]

Int J Med Sci
Kuang Y, Ke M, Liu W, Xu F.
europepmc   +1 more source

HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis

Advanced Science, EarlyView.
Glioblastoma (GBM) growth relies on glutamine synthetase (GS), which is stabilized by histone deacetylase 6 (HDAC6) and deubiquitinated by ubiquitin‐specific peptidase 9, X‐linked (USP9X). HDAC6 promotes GS deacetylation, while USP9X removes its K48‐linked polyubiquitination, enhancing GS stability.
Go Woon Kim, Minhae Cha, Hien Thi My Ong, Jung Yoo, Yu Hyun Jeon, Sang Wu Lee, Soo Yeon Oh, Min‐Jung Kang, Youngsoo Kim, So Hee Kwon   +9 more
wiley   +1 more source

The Lysine Deprotonation Mechanism in a Ubiquitin Conjugating Enzyme. [PDF]

J Phys Chem B
Wathan AJ, Deschene NM, Litz JM, Sumner I.   +3 more
europepmc   +1 more source

Ubiquitin Immunostaining of Concentric Lamellar Bodies in Axon Terminals and Preterminal Axons in Cerebellar and Vestibular Nuclei of Groggy Mutant Rat

, 1994
Ikuo Takeuchi, Yoshiko Takeuchi, Eiko Aoki   +2 more
openalex   +2 more sources

Conjugation of Ubiquitin to Proteins from Green Plant Tissues [PDF]

, 1991
Bjarke Veierskov, Ian B. Ferguson
openalex   +1 more source

Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

Advanced Science, EarlyView.
The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su, Guoqing Wu, Muya Xiong, Yuhang Wang, Junyuan Cao, Mengyuan You, Yingchun Xiang, Tianqing Nie, Minjun Li, Gengfu Xiao, Leike Zhang, Qiang Shao, Yechun Xu   +12 more
wiley   +1 more source

Mechanism of millisecond Lys48-linked poly-ubiquitin chain formation by cullin-RING ligases. [PDF]

Nat Struct Mol Biol
Liwocha J, Li J, Purser N, Rattanasopa C, Maiwald S, Krist DT, Scott DC, Steigenberger B, Prabu JR, Schulman BA, Kleiger G.   +10 more
europepmc   +1 more source