Results 21 to 30 of about 117,989 (312)
International Journal of Molecular Sciences, 2018 Ever since the discovery of ubiquitin in 1975[...]
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Terminating protein ubiquitination [PDF]
Cell Cycle, 2011 Ubiquitination is a post-translational modification that generally directs proteins for degradation by the proteasome or by lysosomes. However, ubiquitination has been implicated in many other cellular processes, including transcriptional regulation, DNA repair, regulation of protein-protein interactions and association with ubiquitin-binding scaffolds.
Daniel K, Stringer, Robert C, Piper
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Growth Hormone Receptor Regulation in Cancer and Chronic Diseases
Frontiers in Endocrinology, 2020 The GHR signaling pathway plays important roles in growth, metabolism, cell cycle control, immunity, homeostatic processes, and chemoresistance via both the JAK/STAT and the SRC pathways. Dysregulation of GHR signaling is associated with various diseases
Ger J. Strous +9 more
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, 2019 Mutations in genes encoding PINK1 (PTEN-induced kinase 1) and Parkin (E3 ubiquitin ligase) are identified in familial Parkinson’s disease.
M. Pan +18 more
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bioRxiv, 2021 UCH37, also known as UCHL5, is a highly conserved deubiquitinating enzyme (DUB) that associates with the 26S proteasome. Recently it was reported that UCH37 activity is stimulated by branched ubiquitin chain architectures.
Aixin Song +12 more
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Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains
Cell Reports, 2016 Myosin VI is critical for cargo trafficking and sorting during early endocytosis and autophagosome maturation, and abnormalities in these processes are linked to cancers, neurodegeneration, deafness, and hypertropic cardiomyopathy.
Fahu He +9 more
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Molecular Plant-Microbe Interactions, 2009 Plant responses against pathogens cause up- and downward shifts in gene expression. To identify differentially expressed genes in a plant-virus interaction, susceptible tomato plants were inoculated with the potyvirus Pepper yellow mosaic virus (PepYMV ...
Poliane Alfenas-Zerbini +5 more
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The dynamics of linear polyubiquitin
Science Advances, 2020 A new efficient method for SAXS-driven simulations allows researchers to explain the dynamics of linear polyubiquitin. Polyubiquitin chains are flexible multidomain proteins, whose conformational dynamics enable them to regulate multiple biological ...
Alexander Jussupow +8 more
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Experimental and Molecular Medicine, 2018 Experimental & molecular medicine Researchers may have found a new target for treatment of multiple myeloma (MM), a common type of blood cancer.
Lili Zhou +7 more
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Frontiers in Physiology, 2018 Structural and functional alterations of mitochondria are intimately linked to a wide array of medical conditions. Many factors are involved in the regulation of mitochondrial function, including cytokines, chaperones, chemokines, neurosteroids, and ...
Victoria O. Polyakova +10 more
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