Ubiquitin-related modifiers of Arabidopsis thaliana influence root development. [PDF]
PLoS ONE, 2014 Ubiquitins are small peptides that allow for posttranslational modification of proteins. Ubiquitin-related modifier (URM) proteins belong to the class of ubiquitin-like proteins. A primary function of URM proteins has been shown to be the sulfur transfer
Florian John +4 more
doaj +1 more source
Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling
Nature Communications, 2020 LUBAC is involved in adding linear ubiquitin chains to important immune signaling proteins. Here the authors show that this mechanism is effective in inhibiting STAT1-mediated interferon signaling, and that the deubiquitinase OTULIN can remove these ...
Yibo Zuo +13 more
doaj +1 more source
Regulation of Wnt Signaling through Ubiquitination and Deubiquitination in Cancers
International Journal of Molecular Sciences, 2020 The Wnt signaling pathway plays important roles in embryonic development, homeostatic processes, cell differentiation, cell polarity, cell proliferation, and cell migration via the β-catenin binding of Wnt target genes.
Hong-Beom Park, Ju-Won Kim, K. Baek
semanticscholar +1 more source
The E3 ligase RAD18-mediated ubiquitination of henipavirus matrix protein promotes its nuclear-cytoplasmic trafficking and viral egress. [PDF]
Emerg Microbes InfectThe nuclear-cytoplasmic trafficking of matrix proteins (M) is essential for henipavirus budding, with M protein ubiquitination playing a pivotal role in this dynamic process.
Jin D +12 more
europepmc +2 more sources
Journal of Physical Chemistry B, 2016 Specificity of protein degradation by cellular proteasomes comes from tetra-ubiquitin recognition. We carry out molecular dynamics simulations to characterize how the ubiquitin receptor Rpn10 recognizes in the 26S proteasome K48-linked tetra-ubiquitin ...
Yi Zhang +4 more
semanticscholar +1 more source
The ubiquitin-proteasome pathway in Huntington's disease. [PDF]
, 2008 The accumulation of mutant protein is a common feature of neurodegenerative disease. In Huntington's disease, a polyglutamine expansion in the huntingtin protein triggers neuronal toxicity.
Finkbeiner, Steven, Mitra, Siddhartha
core +2 more sources
The Ubiquitination Machinery of the Ubiquitin System [PDF]
The Arabidopsis Book, 2014 The protein ubiquitin is a covalent modifier of proteins, including itself. The ubiquitin system encompasses the enzymes required for catalysing attachment of ubiquitin to substrates as well as proteins that bind to ubiquitinated proteins leading them to their final fate.
openaire +5 more sources
RING E3 ligases:key regulatory elements are involved in abiotic stress responses in plants [PDF]
BMB Reports, 2017 Plants are constantly exposed to a variety of abiotic stresses, such as drought, heat, cold, flood, and salinity. To survive under such unfavorable conditions, plants have evolutionarily developed their own resistant-mechanisms. For several decades, many
Cho, Seok Keun +6 more
core +2 more sources
A comparative analysis of the ubiquitination kinetics of multiple degrons to identify an ideal targeting sequence for a proteasome reporter. [PDF]
PLoS ONE, 2013 The ubiquitin proteasome system (UPS) is the primary pathway responsible for the recognition and degradation of misfolded, damaged, or tightly regulated proteins.
Adam T Melvin +5 more
doaj +1 more source
Frontiers in Microbiology, 2022 Phytophthora sp. are invasive groups of pathogens belonging to class Oomycetes. In order to contain and control them, a deep knowledge of their biology and infection strategy is imperative.
Kajal Mandal +7 more
doaj +1 more source