Results 211 to 220 of about 390,663 (288)

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Integrating Artificial Intelligence Into Digital Health-Optimized Therapeutics for the Remote Cardiac Rehabilitation. [PDF]

Clin Med Insights Cardiol
Wan X, Ge L, Tian J, Ding G, Gao B, Geng H, Ge C, Song X.   +7 more
europepmc   +1 more source

Adolescents' Experiences of Hate Speech and Psychological Needs: A Reflexive Thematic Analysis

Journal of Adolescence, EarlyView.
ABSTRACT Introduction Adolescents are increasingly exposed to hate speech in both online and offline contexts, yet limited research has examined how such exposure is experienced and how it relates to adolescents' psychological needs and well‐being. Drawing on Self‐Determination Theory (SDT), this study explores how adolescents make sense of hate speech
Tomas Jungert, Camilla Forsberg, Robert Thornberg, Lisa Nordlund, Emelie Hansen, Elisa Lagerstedt, Coralie Levesque   +6 more
wiley   +1 more source

A ubiquitous and interoperable deep learning model for automatic detection of pleomorphic gastroesophageal lesions. [PDF]

Sci Rep
Martins M, Mascarenhas MJ, Almeida MJ, Afonso J, Ribeiro T, Cardoso P, Mendes F, Mota J, Andrade P, Cardoso H, Mascarenhas-Saraiva M, Ferreira J, Macedo G.   +12 more
europepmc   +1 more source

‘Pre‐Technologies’ and the Lifeworld: Assistive Technologies as ‘Pre‐Technologies’ for Self‐Formation as Freedom

Journal of Applied Philosophy, EarlyView.
ABSTRACT This article identifies assistive technologies (ATs) as ‘pre‐technologies’ mediating access to other technologies for disabled subjects (DSs). The motivation is to show that without ATs, DSs cannot be said to have the same level of access to freedom and self‐forming activities as able‐bodied subjects.
Sarel Marais
wiley   +1 more source

Sparse identification of nonlinear dynamics and Koopman operators with Shallow Recurrent Decoder Networks. [PDF]

Proc Natl Acad Sci U S A
Gao ML, Williams JP, Kutz JN.
europepmc   +1 more source

Fostering Inclusive Excellence: Reimagining Oral Science Research and Admissions to Advance Dentistry During Perilous Times

Journal of Dental Education, EarlyView.
ABSTRACT Purpose: Recent shifts in public policy and legislation have aimed to dismantle progress toward racial equity in the United States, especially within the realm of education. Dental education institutions are responsible for cultivating the oral healthcare workforce of the future, but their ability to meet the growing dental burden is hampered ...
RK, JB, YK, DG
wiley   +1 more source

Minimax Bayesian Neural Networks. [PDF]

Entropy (Basel)
Hong J, Kuruoglu EE.
europepmc   +1 more source

Disrupting the Chain of Displaced Aggression: A Review and Agenda for Future Research

Journal of Organizational Behavior, EarlyView.
ABSTRACT Displaced aggression refers to instances in which a person redirects their harm‐doing behavior from a primary to a secondary, substitute target. Since the publication of the first empirical article in 1948, there has been a noticeable surge in research referencing this theory in both management and psychology journals.
Constantin Lagios, Simon Lloyd D. Restubog, Pauline Schilpzand, Kohyar Kiazad, Karl Aquino   +4 more
wiley   +1 more source