Results 181 to 190 of about 29,730 (229)

Tankyrases and Their Binding Proteins: Origins of Their Roles in Diverse Cellular Pathways. [PDF]

Cells
Chalabi Hagkarim N, Grand RJ.
europepmc   +1 more source

USP40 protects podocytes by deubiquitylating integrin β1. [PDF]

Biochem Biophys Res Commun
Mikami N, Fukushima T, Takematsu H, Kiuchi Z, Fukuhara D, Tanaka E, Kimura T, Suehiro J, Fukutomi T, Kobayashi K, Pastan I, Nagata M, Takano T, Matsusaka T, Akimoto Y, Kawanishi K, Yan K.   +16 more
europepmc   +1 more source

The E3 ubiquitin ligase mechanism specifying targeted microRNA degradation. [PDF]

Nature
Farnung J, Slobodyanyuk E, Wang PY, Blodgett LW, Lin DH, von Gronau S, Schulman BA, Bartel DP.   +7 more
europepmc   +1 more source

Polycomb repression works without Siesta, the <i>Drosophila</i> ortholog of mammalian PCGF3. [PDF]

Sci Adv
Kahn TG, Garrido A, Yushkova A, Kim M, Glotov A, Sreekumar S, Larsson J, Schwartz YB.   +7 more
europepmc   +1 more source

Reversal of ubiquitylation

, 2008
openaire   +1 more source

Non-proteolytic ubiquitylation in cellular signaling and human disease

Communications Biology, 2022
International audienceAbstract Ubiquitylation is one of the most common post-translational modifications (PTMs) of proteins that frequently targets substrates for proteasomal degradation.
Eva Pangou, Izabela Sumara
exaly   +2 more sources

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The regulation of necroptosis by ubiquitylation

Apoptosis, 2022
Necroptosis is a programmed necrosis that is mediated by receptor-interacting protein kinases RIPK1, RIPK3 and the mixed lineage kinase domain-like protein, MLKL. Necroptosis must be strictly regulated to maintain normal tissue homeostasis, and dysregulation of necroptosis leads to the development of various inflammatory, infectious, and degenerative ...
Yiliang, Chen, Wenqing, Ren, Qingsong, Wang, Yuan, He, Dan, Ma, Zhenyu, Cai   +5 more
openaire   +2 more sources

Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass

Nature Cell Biology, 2012
Protein ubiquitylation has emerged as a key regulatory mechanism in DNA-damage signalling and repair pathways. We report a proteome-wide, site-specific survey of ubiquitylation changes after ultraviolet irradiation, identifying numerous upregulated and ...
Petra Beli, Michael Lund Nielsen, Niels Mailand   +2 more
exaly   +2 more sources

Chemical chromatin ubiquitylation

Current Opinion in Chemical Biology, 2018
Histone modifications dynamically regulate chromatin structure and function, thereby mediating many processes that require access to DNA. Chemical protein synthesis has emerged as a powerful approach for generating homogeneously modified histone analogues in workable amounts for subsequent incorporation into nucleosome arrays for biochemical ...
Muhammad, Jbara, Hao, Sun, Guy, Kamnesky, Ashraf, Brik   +3 more
openaire   +2 more sources

Ubiquitylation and Cancer Development

Current Cancer Drug Targets, 2008
Ubiquitylation is an essential cellular process, and yet many cancer cells appear to be more reliant upon it than normal cells as they are surprisingly sensitive to proteasome inhibitors (PI) and proteasome inhibitor drugs are well tolerated in vivo.
Miasari, Maria., Puthalakath, Hamsa., Silke, John Hendry.   +2 more
openaire   +2 more sources