Results 91 to 100 of about 57,370 (289)

UDP-Glucuronosyltransferase Promoter Polymorphism in Iranian Neonates with Idiopathic Hyperbilirubinemia

Acta Medica Iranica, 2013
To determine the association between polymorphism of UGT1A1 gene and idiopathic hyperbilirubinemia in Iranian neonates. Fifty neonates with idiopathic hyperbilirubinemia and Serum total bilirubin (STB) more that 15mg/dl and 50 neonates with idiopathic ...
Mahbod Kaveh, Tahereh Esmailnia, Fatemeh Nayeri, Firoozeh Nili, Fatemeh Davari Tanha, Mahsa Ghajarzdeh   +5 more
doaj  

OATP2B1 Deficiency Ameliorates Irinotecan‐Induced Gastrointestinal Toxicity

Clinical and Translational Science, Volume 19, Issue 1, January 2026.
ABSTRACT Irinotecan (CPT‐11) is a prodrug of the topoisomerase I inhibitor SN‐38 used in the treatment of metastatic carcinomas of the colon or rectum. The clinical utility of this drug is hindered by debilitating side effects, most notably, severe gastrointestinal toxicity, which affects up to 40% of patients.
Hanieh Taheri, Peter de Bruijn, Yang Li, Nicholas R. Kleinert, Kara N. Corps, Ron H. J. Mathijssen, Kevin M. Huang, Alex Sparreboom, Shuiying Hu   +8 more
wiley   +1 more source

ケイカチュウ ニ イッカセイ コウビリルビン ケッショウ オ テイシタ ネフローゼ ショウコウグン ノ 2レイ [PDF]

, 2004
We present two patients with idiopathic nephrotic syndrome who showed temporary indirect hyperbilirubinemia during the course of treatment with immunosuppressant drugs and/or steroids.
Liang Lijun
core   +1 more source

Characterization of a membrane-bound C-glucosyltransferase responsible for carminic acid biosynthesis in Dactylopius coccus Costa [PDF]

, 2017
Carminic acid is a widely applied red colorant that is still harvested from insects because its biosynthesis is not fully understood. Here, the authors identify and characterize a membrane-bound C-glucosyltransferase catalyzing the final step during ...
A Radominska-Pandya, A Radominska-Pandya, A Rath, A Serrano, A Shevchenko, C Senay, D Pompon, DA Benson, DD Gadgil, F Pankewitz, HL Flores-Alatorre, J Magdalou, J Piel, J Piel, J Velíšek, J Wouters, K Lech, KS Brown, KW Bock, L Hernández-Hernández Fde, M Ouzzine, M Ouzzine, PA Joshi, R Kannangara, RD Finn, RLL Kellner, RLL Kellner, RLL Kellner, RW Dapson, S Caselín-Castro, S Caselín-Castro, SJ Ahn, ST Ramirez-Puebla, T Eisner, T Eisner   +34 more
core   +5 more sources

Genotype–Specific Safety and Pharmacokinetics of Cannabidiol in Healthy Volunteers

Clinical and Translational Science, Volume 19, Issue 1, January 2026.
ABSTRACT Cannabidiol (CBD) use has increased in America due to its widespread availability. Cannabidiol is metabolized by multiple polymorphic enzymes including CYP3A, CYP2C9, and CYP2C19. We sought to evaluate the genotype‐specific adverse events and pharmacokinetic profiles of cannabidiol, 7‐OH cannabidiol (an active metabolite), and 7‐COOH ...
Jumar Etkins, Gerald C. So, Jessica Bo Li Lu, Sachiko Koyama, Debora L. Gisch, Ricardo Melo Ferreira, Ying‐Hua Cheng, Kelsey McClara, Joshua Jun, Matthew Miller, Zeruesenay Desta, Michael T. Eadon   +11 more
wiley   +1 more source

Current trends in drug metabolism and pharmacokinetics. [PDF]

, 2019
Pharmacokinetics (PK) is the study of the absorption, distribution, metabolism, and excretion (ADME) processes of a drug. Understanding PK properties is essential for drug development and precision medication.
Abduljalil, Aghazadeh-Habashi, Aigrain, Aitman, Al Za'abi, Alegre, Alnaqeeb, Aspromonte, Babiskin, Baert, Bakke, Barnett, Bhattacharyya, Cang, Cannady, Cao, Cao, Capecchi, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Cheng, Cheng, Crawford, Currie, De Lange, Dean, Deng, Di Paolo, Dietrich, Diliberto, Dluzen, Dowling, Dragin, Dreisbach, Duan, Edeogu, Edginton, El-Arabey, El-Kadi, EMA, Eum, Falany, Fang, FDA, Feng, Feng, Feng, Ferri, Fleming, Foti, Fox, Freedman, Frye, Fukami, Gaj, Gan, Gao, Gao, Gao, Gao, Gao, Ge, Genovese, Gingell, Gingell, Gong, Graham, Gufford, Guo, Guo, Guo, Guévin, Han, Harrison, Hartz, Hasegawa, He, He, He, He, He, Ho, Ho, Hou, Hsu, Hsueh, Hu, Hu, Hu, Huo, Hwang, Ito, Jacob, Jeong, Jeong, Jia, Jian, Jiang, Jiang, Jiang, Jiang, Jilek, Jilek, Johnson, Jorga, Jung, Kaivosaari, Kalthoff, Kaminsky, Kannan, Karibe, Kesisoglou, Kim, Kim, Knights, Kong, Kota, Kumar, Kurokawa, Lai, Lan, Lanchote, Lee, Lehouritis, Li, Li, Li, Li, Li, Li, Li, Li, Li, Li, Li, Liang, Lin, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Lopes-Rodrigues, Lu, Lu, Lu, Löfgren, Mano, Marchitti, Margolskee, Martin, Matsson, Mattick, Mazerska, Mei, Mencia, Meng, Min, Mitra, Miyajima, Müller, Nair, Nakano, Nakano, Nakano, Nebert, Nguyen, Niederalt, Nieto Montesinos, Niu, Notenboom, Nozaki, Ohtsuki, Ono, Oostendorp, Pan, Pan, Papageorgiou, Papageorgiou, Park, Pea, Pedersen, Pelkonen, Pellegrino, Pettersson Bergstrand, Qi, Qin, Qiu, Qiu, Raaska, Rives, Riviere, Roberts, Robey, Rocha, Rose, Routy, Rowland, Ruwali, Saini, Satoh, Savage, Scheer, Scheer, Schlender, Schmitt, Schneider, Seitz, Showande, Shu, Shu, Shu, Shugarts, Siu, Song, Staudinger, Strong, Suarez-Sharp, Suh, Suiko, Sukkummee, Sun, Sun, Sutliff, Takeda, Tan, Tan, Tao, Tatsumi, Teorell, Tsai, Tsang, Tsuchiya, Tsume, Tu, Ulldemolins, van Waterschoot, von Richter, Vugmeyster, Vuppugalla, Wagner, Wagner, Wagner, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wassenaar, Watanabe, Wei, Wijayakumara, Wilkinson, Wong, Wu, Xia, Xie, Xie, Xu, Xu, Xu, Xu, Xu, Xue, Yamagata, Yamaguchi, Yan, Yang, Yang, Yang, Ye, Yellepeddi, Yi, Yi, Yigitaslan, Yim, Yin, Yoshida, Yoshida, Yoshimi, Yu, Yu, Yu, Yu, Yu, Yu, Yu, Zakeri-Milani, Zanger, Zeng, Zeng, Zhai, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zhao, Zhao, Zhao, Zhou, Zhou, Zhou, Zhou, Zhou, Zhu, Zhu, Zhu, Zhuang, Zimmermann   +332 more
core   +1 more source

Transcriptomic Association Analysis of the Metabolic Mechanism of Sulfamethoxazole in Channel Catfish (Ictalurus punctatus)

Animals
Sulfamethoxazole is a widely used antimicrobial drug used to treat bacterial diseases in aquaculture. To understand the gene expression in channel catfish liver after treatment with sulfamethoxazole, in this study, the treatment group received ...
Xiangxuan Du, Ruyu Sun, Lei Zhang, Yongtao Liu, Xiaohui Ai   +4 more
doaj   +1 more source

Induction of UDP-glucuronosyltransferase 1A by naturally occurring phytochemicals in human hepatoma cells

Journal of Medical Science, 2014
UDP-glucuronosyltransferases (UGTs) are important detoxification and drug-metabolizing enzymes, which catalyse the glucuronidation of exogenous and endogenous chemicals. The anti-carcinogenic activity of dietary phytochemicals is partly attributed to the
Violetta Krajka-Kuźniak, Adam Krysztofiak, Jarosław Paluszczak   +2 more
doaj   +1 more source

Impact of UGT1A1 gene variants on total bilirubin levels in Gilbert syndrome patients and in healthy subjects [PDF]

, 2012
A significant different allelic distribution, in Gilbert patients and in controls, was found for two promoter polymorphisms. Among patients, 82.2% were homozygous and 17.8% heterozygous for the c.− 41_ − 40dupTA allele; in control group, 9.9% were ...
Bronze-da-Rocha, Elsa, Carvalho, João, Costa, Elísio, Rodrigues, Carina, Santos, Rosário, Santos-Silva, Alice, Vieira, Emília   +6 more
core   +3 more sources

A Comparative Analysis of Michaelis-Menten, Hill, and Allosteric Models in Drug Metabolism

Iraqi Journal of Industrial Research
Background: Enzyme Kinetics it is a fundamental part of metabolic biochemistry because it helps to explore the mechanism of action and interaction of all substrates under the influence as well as environmental factors.
Ziyad K. Radeef
doaj   +1 more source