Results 101 to 110 of about 7,973 (164)
The effects of zinc sulfate on ethyl glucuronide immunoassay urine testing [PDF]
, 2016 Published research in the Journal of Analytical Toxicology and the American Society for Clinical Pathology has confirmed that the presence of Zinc Sulfate in adulterated urine samples can influence the testing results using EMIT and ELISA immunoassay ...
Cawley, Shanna Marie
core +1 more source
Development of icterus gravis in a preterm infant with G71R UGT1A1 polymorphism [PDF]
, 2013 BACKGROUND: Uridine diphosphate-glucuronosyltransferase (UGT) gene family is involved in the detoxification of biomaterials and drugs in the liver. Among the UGT gene family members, only UGT1A1 is involved in bilirubin conjugation.
Akimune Kaga +9 more
core +1 more source
Irinotecan pathway genotype analysis to predict pharmacokinetics [PDF]
, 2003 PURPOSE: The purpose was to explore the relationships between irinotecan disposition and allelic variants of genes coding for adenosine triphosphate binding cassette transporters and enzymes of putative relevance for irinotecan ...
Baker, S.D. (Sharyn) +7 more
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InsectsInsect-resistant substances from plants are important natural resources that human beings can potentially develop and use to control pests. In this study, we explored the adverse effects of rutin and quercetin on grasshopper (Calliptamus abbreviatus), as
Xunbing Huang, Li Zheng, Yueyue Wang
doaj +1 more source
La farmacogenetica dei farmaci antitumorali [PDF]
, 2014 La variabilità individuale nella risposta ai farmaci è molto importante in quanto può condizionare la riuscita di un trattamento farmacologico ed è dovuta, in gran parte, al profilo genetico.
IOFRIDA, CATERINA
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Establishment of the experimental procedure for prediction of conjugation capacity in mutant UGT1A1.
PLoS ONE, 2019 UDP-glucuronosyltransferase 1A1 (UGT1A1) is an enzyme that is found in the endoplasmic reticulum membrane and can reportedly have a large number of amino acid substitutions that result in the reduction of glucuronidation capacity.
Yutaka Takaoka +11 more
doaj +1 more source
Functional expression of uridine diphospho glucuronosyltransferases in fission yeast [PDF]
, 2011 Uridine diphospho (UDP) glucuronosyltransferases (UGTs) catalyze the transfer of a sugar moiety from UDP-sugar to endogenous or exogenous compounds. The water solubility of these substances is increased thereby and their excretion from the human body is ...
Buchheit, Daniela
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Gilbert Syndrome and the Development of Antiretroviral Therapy-Associated Hyperbilirubinemia [PDF]
, 2017 BackgroundUnconjugated hyperbilirubinemia results from Gilbert syndrome and from antiretroviral therapy (ART) containing protease inhibitors. An understanding of the interaction between genetic predisposition and ART may help to identify individuals at ...
Bernasconi, Enos +9 more
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Characterization of Isolated Bioactive Phytoconstituents from Flacourtia Indica as Potential Phytopharmaceuticals-An in Silico Perspective [PDF]
, 2016 The dependence of mankind for therapeutic applications on plants dates back to the start of the human race. Natural remedies from ethnobotanicals are found to be safe and cost effective.
Arbaaz Ahmed, L. +3 more
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Journal of CheminformaticsUDP-glucuronosyltransferases (UGTs) play a critical role in drug metabolism by catalyzing the glucuronidation of structurally diverse compounds. However, accurately predicting UGT-mediated sites of metabolism (SOMs) remains a challenge due to the limited
Meiling Zhan +7 more
doaj +1 more source