Dietary moderately oxidized oil activates the Nrf2 signaling pathway in the liver of pigs
Lipids in Health and Disease, 2012 Background Previous studies have shown that administration of oxidized oils increases gene expression and activities of various enzymes involved in xenobiotic metabolism and stress response in the liver of rats and guinea pigs.
Varady Juliane +4 more
doaj +1 more source
La farmacogenetica dei farmaci antitumorali [PDF]
, 2014 La variabilità individuale nella risposta ai farmaci è molto importante in quanto può condizionare la riuscita di un trattamento farmacologico ed è dovuta, in gran parte, al profilo genetico.
IOFRIDA, CATERINA
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Development of icterus gravis in a preterm infant with G71R UGT1A1 polymorphism [PDF]
, 2013 BACKGROUND: Uridine diphosphate-glucuronosyltransferase (UGT) gene family is involved in the detoxification of biomaterials and drugs in the liver. Among the UGT gene family members, only UGT1A1 is involved in bilirubin conjugation.
Akimune Kaga +9 more
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PPARα contributes to protection against metabolic and inflammatory derangements associated with acute kidney injury in experimental sepsis [PDF]
, 2019 Sepsis‐associated acute kidney injury (AKI) is a significant problem in critically ill children and adults resulting in increased morbidity and mortality. Fundamental mechanisms contributing to sepsis‐associated AKI are poorly understood.
Bennion, Brock G +10 more
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The effects of zinc sulfate on ethyl glucuronide immunoassay urine testing [PDF]
, 2016 Published research in the Journal of Analytical Toxicology and the American Society for Clinical Pathology has confirmed that the presence of Zinc Sulfate in adulterated urine samples can influence the testing results using EMIT and ELISA immunoassay ...
Cawley, Shanna Marie
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Role of DNA methylation in altered gene expression patterns in adult zebrafish (Danio rerio) exposed to 3, 3’, 4, 4’, 5-pentachlorobiphenyl (PCB 126) [PDF]
, 2018 © The Author(s), 2018. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Environmental Epigenetics 4 (2018): dvy005, doi:10.1093/eep/dvy005.There is growing evidence that ...
Aluru, Neelakanteswar +4 more
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Strain differences in purified rat hepatic 3 α-hydroxysteroid UDP-glucuronosyltransferase [PDF]
, 1985 M D Green +3 more
openalex +1 more source
Maternal urinary bisphenol a during pregnancy and maternal and neonatal thyroid function in the CHAMACOS study. [PDF]
, 2013 BackgroundBisphenol A (BPA) is widely used in the manufacture of polycarbonate plastic bottles, food and beverage can linings, thermal receipts, and dental sealants. Animal and human studies suggest that BPA may disrupt thyroid function. Although thyroid
Bradman, Asa +6 more
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Acta Pharmaceutica Sinica B, 2017 UDP-glucuronosyltransferase 1A1 (UGT1A1) plays a key role in detoxification of many potentially harmful compounds and drugs. UGT1A1 inhibition may bring risks of drug–drug interactions (DDIs), hyperbilirubinemia and drug-induced liver injury.
Xuewei Cheng +7 more
doaj +1 more source
Irinotecan pathway genotype analysis to predict pharmacokinetics [PDF]
, 2003 PURPOSE: The purpose was to explore the relationships between irinotecan disposition and allelic variants of genes coding for adenosine triphosphate binding cassette transporters and enzymes of putative relevance for irinotecan ...
Baker, S.D. (Sharyn) +7 more
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