Results 181 to 190 of about 72,405 (234)

Polymorphisms of UDP-Glucuronosyltransferase and Pharmacokinetics of Irinotecan

Therapeutic Drug Monitoring, 2002
Irinotecan is a prodrug that is hydrolyzed by carboxylesterase in vivo to form an active metabolite SN-38. SN-38 is further conjugated and detoxified by UDP-glucuronosyltransferase (UGT) to yield its beta-glucuronide (SN-38G). Although irinotecan is widely used, the drug causes unpredictably severe, occasionally fatal, toxicity of leukopenia or ...
Yuichi, Ando, Hiroshi, Ueoka, Toru, Sugiyama, Masao, Ichiki, Kaoru, Shimokata, Yoshinori, Hasegawa   +5 more
openaire   +2 more sources

STRUCTURAL AND FUNCTIONAL STUDIES OF UDP-GLUCURONOSYLTRANSFERASES*

Drug Metabolism Reviews, 1999
UDP-Glucuronosyltransferases (UGTs) are glycoproteins localized in the endoplasmic reticulum (ER) which catalyze the conjugation of a broad variety of lipophilic aglycon substrates with glucuronic acid using UDP-glucuronic acid (UDP-GIcUA) as the sugar donor. Glucuronidation is a major factor in the elimination of lipophilic compounds from the body. In
A, Radominska-Pandya, P J, Czernik, J M, Little, E, Battaglia, P I, Mackenzie   +4 more
openaire   +2 more sources

The inhibition of UDP-glucuronosyltransferases (UGTs) by vitamin A

Xenobiotica, 2016
1. The exposed level of vitamin A in plasma might be exceeded due to the both inadvertent and clinical utilization. The adverse effects of vitamin A have been frequently reported, however, the mechanism remains unclear. The inhibition of vitamin A on the activity of UDP-glucuronosyltransferases (UGTs) was determined using in vitro incubation system to ...
Xin, Liu, Yun-Feng, Cao, Pei-Pei, Dong, Liang-Liang, Zhu, Zhenying, Zhao, Xue, Wu, Zhi-Wei, Fu, Chun-Ting, Huang, Zhong-Ze, Fang, Hong-Zhi, Sun   +9 more
openaire   +2 more sources

Metabolism of Endobiotics and Xenobiotics by UDP-Glucuronosyltransferase

1997
Publisher Summary All organisms are exposed to a number of chemical compounds that are toxic were it not for metabolic mechanisms available to the organism to moderate their effects. Chemical substances may be xenobiotics, such as drugs, or compounds presented to the organism from environmental or dietary sources.
T R, Tephly, M D, Green, B L, Coffman, C, King, Z, Cheng, G, Rios   +5 more
openaire   +2 more sources

UDP-glucuronosyltransferases

Pharmacology & Therapeutics, 1989
B, Burchell, M W, Coughtrie
openaire   +2 more sources

Roles of UDP-Glucuronosyltransferases in Chemical Carcinogenesi

Critical Reviews in Biochemistry and Molecular Biology, 1991
UDP-glucuronosyltransferases (UGT) play a major role in the elimination of nucleophilic metabolites of carcinogens, such as phenols and quinols of polycyclic aromatic hydrocarbons. In this way they prevent their further oxidation to electrophiles, which may react with DNA, RNA, and protein.
openaire   +2 more sources

UDP-Glucuronosyltransferase inhibitors

European Journal of Drug Metabolism and Pharmacokinetics, 1998
E, Golovinsky, Z, Naydenova, K, Grancharov   +2 more
openaire   +2 more sources

Inhibition of human UDP‐glucuronosyltransferase enzymes by lapatinib, pazopanib, regorafenib and sorafenib: Implications for hyperbilirubinemia

Biochemical Pharmacology, 2017
J. Miners, N. Chau, A. Rowland, Kushari Burns, R. Mckinnon, P. Mackenzie, G. Tucker, K. Knights, G. Kichenadasse   +8 more
semanticscholar   +1 more source

Transcriptional Regulation of UDP-Glucuronosyltransferases

2009
Totowa, New ...
Xie, Wen, Mackenzie, Peter Ian, Radominska-Pandya, A   +2 more
openaire   +1 more source

A Molecular‐Splicing Strategy for Constructing a Near‐Infrared Fluorescent Probe for UDP‐Glucuronosyltransferase 1A1

Angewandte Chemie - International Edition, 2021
Xiangge Tian, Tao Liu, Jian Gao
exaly