Results 161 to 170 of about 72,405 (234)

Characterization of the Ontogeny of Hepatic UDP‐Glucuronosyltransferase Enzymes Based on Glucuronidation Activity Measured in Human Liver Microsomes

Journal of clinical pharmacology, 2019
An understanding of the postnatal development of hepatic UDP‐glucuronosyltransferase (UGT) enzymes is required for accurate prediction of the age‐dependent changes in pharmacokinetics of many drugs used in children.
J. Badée, N. Qiu, A. Collier, Ryan H Takahashi, W. Forrest, N. Parrott, S. Schmidt, S. Fowler   +7 more
semanticscholar   +1 more source

Regulation of UDP Glucuronosyltransferase Genes

Current Drug Metabolism, 2003
The UDP glucuronosyltransferase (UGT) content of cells and tissues is a major determinant of our response to those chemicals that are primarily eliminated by conjugation with glucuronic acid. There are marked interindividual differences in the content of UGTs in the liver and other organs.
Nishiyama, Takahito, Xie, Wen, Gregory, Philip A, Lewinsky, Rikke Holm, Jorgensen, Bo R, Mackenzie, Peter Ian, Gardner-Stephen, Dione Anne, Radominska-Pandya, A   +7 more
openaire   +3 more sources

The UDP-Glucuronosyltransferases as Oligomeric Enzymes

Current Drug Metabolism, 2008
The UDP-glucuronosyltransferases (UGTs) are integral membrane proteins of the endoplasmic reticulum that play important roles in the defense against potentially hazardous xenobiotics. The UGTs also participate in the metabolism and homeostasis of many endogenous compounds, including bilirubin and steroid hormones.
Moshe, Finel, Mika, Kurkela
openaire   +2 more sources

UDP-Glucuronosyltransferase in gilbert’s syndrome

Pathology, 1996
The diagnosis of Gilbert's syndrome, a condition characterised by mild jaundice related to chronic unconjugated hyperbilirubinemia, is often presumptive and the pathogenesis is incompletely understood. It would be of interest to develop an immunohistochemical staining method to confirm a diagnosis of Gilbert's syndrome.
H S, Debinski, C S, Lee, A P, Dhillon, P, Mackenzie, J, Rhode, P V, Desmond   +5 more
openaire   +2 more sources

Inhibition of aflatoxins on UDP-glucuronosyltransferases (UGTs)

Toxicology in Vitro, 2023
Aflatoxins have been recognized as the most harmful mycotoxins leading to various toxic effects. The present study aims to determine the inhibition behavior of aflatoxins on the activity of the important phase II metabolizing enzymes, UDP-glucuronosyltransferases (UGTs), based on in vitro incubation system of recombinant human UGTs-catalyzed ...
Zuo, Du, Zhen-Zhong, Liu
openaire   +2 more sources

Human UDP-Glucuronosyltransferase 2B7

Current Drug Metabolism, 2001
UDP-Glucuronosyltransferases (UGTs) are glycoproteins, localized in endoplasmic reticulum (ER) and nuclear membranes, which catalyze the confugation of a broad variety of lipophilic aglycon substrates with glucuronic acid using UDP-glucuronic acid (UDP-GlcUA) as the sugar donor.
A, Radominska-Pandya, J M, Little, P J, Czernik   +2 more
openaire   +2 more sources

Regulation of Mammalian UDP-Glucuronosyltransferases

Current Drug Metabolism, 2018
UDP-glucuronosyltransferases (UGTs) are a class of important phase II drug metabolizing enzymes (DMEs), playing essential roles in the homeostasis of endobiotics as well as the dispositional behavior of exogenous compounds. The expression and enzyme activity of UGTs are regulated by multiple dimensions of mechanisms and can be influenced by diverse ...
Hong, Wang, Guoxiu, Cao, Guangji, Wang, Haiping, Hao   +3 more
openaire   +2 more sources

UDP-Glucuronosyltransferases*

2010
United ...
Mackenzie, Peter Ian, Gardner-Stephen, Dione Anne, Miners, John Oliver   +2 more
openaire   +2 more sources

Structure of UDP‐Glucuronosyltransferases in Membranes

2005
This chapter presents the most recent experimental approaches to the investigation of UDP-glucuronosyltransferase (UGTs) in membranes. The first topic described is the subcellular localization of UGTs with special emphasis on the association of these proteins with the endoplasmic reticulum (ER).
Anna, Radominska-Pandya, Mohamed, Ouzzine, Sylvie, Fournel-Gigleux, Jacques, Magdalou   +3 more
openaire   +2 more sources

Polymorphism of UDP-Glucuronosyltransferase and Drug Metabolism

Current Drug Metabolism, 2005
UDP-glucuronosyltransferase is a group of catabolic enzymes involved in the detoxification and excretion of many xenobiotic and endogeneous substances in intrahepatic and extrahepatic tissues. The group consists of two subfamilies, UGT1 and UGT2. UGT1 consists of 5 exons and has a unique gene structure.
Yoshihiro, Maruo, Masaru, Iwai, Asami, Mori, Hiroshi, Sato, Yoshihiro, Takeuchi   +4 more
openaire   +2 more sources