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The UDP-Glucuronosyltransferases as Oligomeric Enzymes
Current Drug Metabolism, 2008The UDP-glucuronosyltransferases (UGTs) are integral membrane proteins of the endoplasmic reticulum that play important roles in the defense against potentially hazardous xenobiotics. The UGTs also participate in the metabolism and homeostasis of many endogenous compounds, including bilirubin and steroid hormones.
Moshe, Finel, Mika, Kurkela
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Human UDP-Glucuronosyltransferase 2B7
Current Drug Metabolism, 2001UDP-Glucuronosyltransferases (UGTs) are glycoproteins, localized in endoplasmic reticulum (ER) and nuclear membranes, which catalyze the confugation of a broad variety of lipophilic aglycon substrates with glucuronic acid using UDP-glucuronic acid (UDP-GlcUA) as the sugar donor.
A, Radominska-Pandya +2 more
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Inhibition of aflatoxins on UDP-glucuronosyltransferases (UGTs)
Toxicology in Vitro, 2023Aflatoxins have been recognized as the most harmful mycotoxins leading to various toxic effects. The present study aims to determine the inhibition behavior of aflatoxins on the activity of the important phase II metabolizing enzymes, UDP-glucuronosyltransferases (UGTs), based on in vitro incubation system of recombinant human UGTs-catalyzed ...
Zuo, Du, Zhen-Zhong, Liu
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UDP-Glucuronosyltransferase in gilbertâs syndrome
Pathology, 1996The diagnosis of Gilbert's syndrome, a condition characterised by mild jaundice related to chronic unconjugated hyperbilirubinemia, is often presumptive and the pathogenesis is incompletely understood. It would be of interest to develop an immunohistochemical staining method to confirm a diagnosis of Gilbert's syndrome.
H S, Debinski +5 more
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Regulation of Mammalian UDP-Glucuronosyltransferases
Current Drug Metabolism, 2018UDP-glucuronosyltransferases (UGTs) are a class of important phase II drug metabolizing enzymes (DMEs), playing essential roles in the homeostasis of endobiotics as well as the dispositional behavior of exogenous compounds. The expression and enzyme activity of UGTs are regulated by multiple dimensions of mechanisms and can be influenced by diverse ...
Hong, Wang +3 more
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Structure of UDPâGlucuronosyltransferases in Membranes
2005This chapter presents the most recent experimental approaches to the investigation of UDP-glucuronosyltransferase (UGTs) in membranes. The first topic described is the subcellular localization of UGTs with special emphasis on the association of these proteins with the endoplasmic reticulum (ER).
Anna, Radominska-Pandya +3 more
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Polymorphism of UDP-Glucuronosyltransferase and Drug Metabolism
Current Drug Metabolism, 2005UDP-glucuronosyltransferase is a group of catabolic enzymes involved in the detoxification and excretion of many xenobiotic and endogeneous substances in intrahepatic and extrahepatic tissues. The group consists of two subfamilies, UGT1 and UGT2. UGT1 consists of 5 exons and has a unique gene structure.
Yoshihiro, Maruo +4 more
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Ontogenesis of UDP-glucuronosyltransferase enzymes in sheep
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2011UDP glucuronosyltransferases (UGTs) are important for the metabolism of many drugs. To understand the ontogeny of these enzymes in sheep (Ovis aries), knowledge of their expression levels at different developmental stages is important. cDNA sequences of six UGTs (UGT1A1, UGT1A3, UGT1A4, UGT1A6 and UGT1A9) were cloned in sheep liver by rapid ...
Manoja, Pretheeban +4 more
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