Results 131 to 140 of about 53,054 (215)

New Aspects of UDP-glucuronosyltransferase

Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics, 2010
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UDP-Glucuronosyltransferase 2B7

Definitions, 2020
UDP-glucuronosyltransferase 2B7 (529 aa, ~61 kDa) is encoded by the human UGT2B7 gene. This protein plays a role in regulating the metabolism of estrogen metabolites.
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Evidence-based strategies for the characterisation of human drug and chemical glucuronidation in vitro and UDP-glucuronosyltransferase reaction phenotyping.

Pharmacology and Therapeutics, 2020
Enzymes of the UDP-glucuronosyltransferase (UGT) superfamily contribute to the elimination of drugs from almost all therapeutic classes. Awareness of the importance of glucuronidation as a drug clearance mechanism along with increased knowledge of the ...
J. Miners, A. Rowland, J. Novak, K. Lapham, T. Goosen   +4 more
semanticscholar   +1 more source

UDP-Glucuronosyltransferases

Current Drug Metabolism, 2000
Glucuronidation represents a major pathway which enhances the elimination of many lipophilic xenobiotics and endobiotics to more water-soluble compounds. The UDP-glucuronosyltransferase (UGT) family catalyzes the glucuronidation of the glycosyl group of a nucleotide sugar to an acceptor compound (aglycone) at a nucleophilic functional group of oxygen ...
C D, King, G R, Rios, M D, Green, T R, Tephly   +3 more
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Genetic polymorphisms of human UDP-glucuronosyltransferase (UGT) genes and cancer risk

Drug Metabolism Reviews, 2016
Peter Mackenzie, Ross Mckinnon, Dong Gui Hu   +2 more
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Steroid UDP glucuronosyltransferases

The Journal of Steroid Biochemistry and Molecular Biology, 1992
The glucuronidation of steroids is a major process necessary for their elimination in the bile and urine. In general, steroid glucuronides are biologically less reactive than their parent steroids. However, in some cases often associated with disease and steroid therapy, more reactive or toxic glucuronides may be formed.
P I, Mackenzie, L, Rodbourne, S, Stranks
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Heterodimerization of Human UDP-Glucuronosyltransferase 1A9 and UDP-Glucuronosyltransferase 2B7 Alters Their Glucuronidation Activities

Drug Metabolism and Disposition, 2023
Human UDP-glucuronosyltransferases (UGTs) play a pivotal role as prominent phase II metabolic enzymes, mediating the glucuronidation of both endobiotics and xenobiotics. Dimerization greatly modulates the enzymatic activities of UGTs. In this study, we examined the influence of three mutations (H35A, H268Y, and N68A/N315A) and four truncations (signal ...
Jia Xue, Jiayi Yin, Jing Nie, Huidi Jiang, Haitao Zhang, Su Zeng   +5 more
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Transcriptional regulation of human UDP-glucuronosyltransferase genes

Drug Metabolism Reviews, 2014
Peter Mackenzie, Ross Mckinnon, Dong Gui Hu   +2 more
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Characterization of the Ontogeny of Hepatic UDP‐Glucuronosyltransferase Enzymes Based on Glucuronidation Activity Measured in Human Liver Microsomes

Journal of clinical pharmacology, 2019
An understanding of the postnatal development of hepatic UDP‐glucuronosyltransferase (UGT) enzymes is required for accurate prediction of the age‐dependent changes in pharmacokinetics of many drugs used in children.
J. Badée, N. Qiu, A. Collier, Ryan H Takahashi, W. Forrest, N. Parrott, S. Schmidt, S. Fowler   +7 more
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Regulation of UDP Glucuronosyltransferase Genes

Current Drug Metabolism, 2003
The UDP glucuronosyltransferase (UGT) content of cells and tissues is a major determinant of our response to those chemicals that are primarily eliminated by conjugation with glucuronic acid. There are marked interindividual differences in the content of UGTs in the liver and other organs.
Nishiyama, Takahito, Xie, Wen, Gregory, Philip A, Lewinsky, Rikke Holm, Jorgensen, Bo R, Mackenzie, Peter Ian, Gardner-Stephen, Dione Anne, Radominska-Pandya, A   +7 more
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