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New Aspects of UDP-glucuronosyltransferase
Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics, 2010 openaire +1 more source
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Genetic polymorphisms of human UDP-glucuronosyltransferase (UGT) genes and cancer risk
Drug Metabolism Reviews, 2016Dong Gui Hu +2 more
exaly +2 more sources
Transcriptional regulation of human UDP-glucuronosyltransferase genes
Drug Metabolism Reviews, 2014Dong Gui Hu +2 more
exaly +2 more sources
Clinical Pharmacokinetics, 2018 Limited understanding of drug pharmacokinetics in children is one of the major challenges in paediatric drug development. This is most critical in neonates and infants owing to rapid changes in physiological functions, especially in the activity of drug ...
J. Badée +5 more
semanticscholar +2 more sources
Genetic variation in bilirubin UDP-glucuronosyltransferase gene promoter and Gilbert's syndrome
Lancet, The, 1996G Monaghan, R Hume, B Burchell
exaly +2 more sources
Pharmacology and Therapeutics, 2020
Enzymes of the UDP-glucuronosyltransferase (UGT) superfamily contribute to the elimination of drugs from almost all therapeutic classes. Awareness of the importance of glucuronidation as a drug clearance mechanism along with increased knowledge of the ...
J. Miners +4 more
semanticscholar +1 more source
Enzymes of the UDP-glucuronosyltransferase (UGT) superfamily contribute to the elimination of drugs from almost all therapeutic classes. Awareness of the importance of glucuronidation as a drug clearance mechanism along with increased knowledge of the ...
J. Miners +4 more
semanticscholar +1 more source
Current Drug Metabolism, 2000
Glucuronidation represents a major pathway which enhances the elimination of many lipophilic xenobiotics and endobiotics to more water-soluble compounds. The UDP-glucuronosyltransferase (UGT) family catalyzes the glucuronidation of the glycosyl group of a nucleotide sugar to an acceptor compound (aglycone) at a nucleophilic functional group of oxygen ...
C D, King +3 more
openaire +2 more sources
Glucuronidation represents a major pathway which enhances the elimination of many lipophilic xenobiotics and endobiotics to more water-soluble compounds. The UDP-glucuronosyltransferase (UGT) family catalyzes the glucuronidation of the glycosyl group of a nucleotide sugar to an acceptor compound (aglycone) at a nucleophilic functional group of oxygen ...
C D, King +3 more
openaire +2 more sources
Steroid UDP glucuronosyltransferases
The Journal of Steroid Biochemistry and Molecular Biology, 1992The glucuronidation of steroids is a major process necessary for their elimination in the bile and urine. In general, steroid glucuronides are biologically less reactive than their parent steroids. However, in some cases often associated with disease and steroid therapy, more reactive or toxic glucuronides may be formed.
P I, Mackenzie, L, Rodbourne, S, Stranks
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Drug Metabolism and Disposition, 2023
Human UDP-glucuronosyltransferases (UGTs) play a pivotal role as prominent phase II metabolic enzymes, mediating the glucuronidation of both endobiotics and xenobiotics. Dimerization greatly modulates the enzymatic activities of UGTs. In this study, we examined the influence of three mutations (H35A, H268Y, and N68A/N315A) and four truncations (signal ...
Jia Xue +5 more
openaire +2 more sources
Human UDP-glucuronosyltransferases (UGTs) play a pivotal role as prominent phase II metabolic enzymes, mediating the glucuronidation of both endobiotics and xenobiotics. Dimerization greatly modulates the enzymatic activities of UGTs. In this study, we examined the influence of three mutations (H35A, H268Y, and N68A/N315A) and four truncations (signal ...
Jia Xue +5 more
openaire +2 more sources