Results 171 to 180 of about 72,405 (234)

Ontogenesis of UDP-glucuronosyltransferase enzymes in sheep

Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2011
UDP glucuronosyltransferases (UGTs) are important for the metabolism of many drugs. To understand the ontogeny of these enzymes in sheep (Ovis aries), knowledge of their expression levels at different developmental stages is important. cDNA sequences of six UGTs (UGT1A1, UGT1A3, UGT1A4, UGT1A6 and UGT1A9) were cloned in sheep liver by rapid ...
Manoja, Pretheeban, Geoff, Hammond, Stelvio, Bandiera, Wayne, Riggs, Dan, Rurak   +4 more
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Isolation and purification of UDP-glucuronosyltransferases

Chemical Research in Toxicology, 1990
UDPGTs are members of a class of enzymes located in the endoplasmic reticulum and are encoded by a multigene family. These proteins are responsible for the glucuronidation of hundreds of xenobiotics of many chemical classes and many endogenous substances such as steroid hormones, bile acids, and bilirubin.
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Natural and synthetic inhibitors of UDP-glucuronosyltransferase

Pharmacology & Therapeutics, 2001
Glucuronidation is a major detoxification pathway in vertebrates. The reaction is catalyzed by a family of UDP-glucuronosyltransferases (UGTs) and involves conjugation of many endobiotic and xenobiotic substances with glucuronic acid, forming inactive water-soluble glucuronides.
K, Grancharov, Z, Naydenova, S, Lozeva, E, Golovinsky   +3 more
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Development of Human Liver UDP-Glucuronosyltransferases

Developmental Pharmacology and Therapeutics, 2017
The development of multiple UDPGT activities towards eight substrates has been studied in fetal term and adult post-mortem (less than 5 h after death) liver samples. Most fetal and term liver activities were less than 14% of adult values, except that towards 5-hydroxytryptamine which was present in fetal and term liver at adult levels.
B, Burchell, M, Coughtrie, M, Jackson, D, Harding, S, Fournel-Gigleux, J, Leakey, R, Hume   +6 more
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UDP-glucuronosyltransferases: a family of detoxifying enzymes

Trends in Pharmacological Sciences, 1990
Glucuronidation is an important process in the metabolism of xenobiotic and endogenous substances leading to enhancement of excretion of these compounds from the body. A multigene family encodes a number of UDP-glucuronosyltransferase enzymes which catalyse this route of metabolism.
T R, Tephly, B, Burchell
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Regulation of UDP glucuronosyltransferases in the gastrointestinal tract

Toxicology and Applied Pharmacology, 2004
The UDP glucuronosyltransferases (UGT) of the gastrointestinal (GI) tract have a crucial role in protection against the toxic effects of lipophilic chemicals in the environment. UGTs such as UGT1A7, UGT1A8, and UGT1A10 are exclusively expressed in gastrointestinal tissues, each with a unique tissue distribution pattern that is subject to ...
Gregory, Philip A, Lewinsky, Rikke Holm, Mackenzie, Peter Ian, Gardner-Stephen, Dione Anne   +3 more
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UDP glucuronosyltransferase in the cirrhotic rat liver

Journal of Gastroenterology and Hepatology, 1996
AbstractIn patients with cirrhosis, the elimination of drugs metabolized by glucuronidation is relatively preserved, in comparison with the metabolism of drugs by oxidation. This study explores this phenomenon at a molecular level. In cirrhotic rat livers the content of UDP‐glucuronosyltransferase (UGT) was examined by immunohistochemistry and ...
H S, Debinski, P I, Mackenzie, C S, Lee, M L, Mashford, J A, Danks, T R, Tephly, M, Green, P V, Desmond   +7 more
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UDP-glucuronosyltransferases in human intestinal mucosa

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1998
While UDP-glucuronosyltransferases (UGTs) are known to be expressed at high levels in human liver, relatively little is known about extrahepatic expression. In the present study, UGT2B family isoforms involved in the glucuronidation of steroid hormones and bile acids have been characterized in microsomes prepared from jejunum, ileum and colon from six ...
A, Radominska-Pandya, J M, Little, J T, Pandya, T R, Tephly, C D, King, G W, Barone, J P, Raufman   +6 more
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GLUCURONIDATION AND THE UDP-GLUCURONOSYLTRANSFERASES IN HEALTH AND DISEASE

Drug Metabolism and Disposition, 2004
This article is an updated report of a symposium held at the June 2000 annual meeting of the American Society for Pharmacology and Experimental Therapeutics in Boston. The symposium was sponsored by the ASPET Divisions for Drug Metabolism and Molecular Pharmacology.
Wells, Peter G, Hansen, Antony J, Gregory, Philip A, Ishii, Yuji, Mackenzie, Peter Ian, Guillemette, Chantal, Chowdhury, Jayanta Roy, Choudhury, Namita R, Kessler, Fay K, Kim, Perry M, Ritter, Joseph K   +10 more
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Cloning and Characterization of a Canine UDP-Glucuronosyltransferase

Archives of Biochemistry and Biophysics, 2001
UDP-glucuronosyltransferases (UGTs) are a major family of enzymes catalyzing the transfer of glucuronic acid to a range of endogenous compounds and xenobiotics facilitating their elimination in either urine or bile. Although the dog is commonly used in drug metabolism studies, relatively little is known about the expression and activity of UGTs in this
M G, Soars, D J, Smith, R J, Riley, B, Burchell   +3 more
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