Results 41 to 50 of about 12,805 (208)

The UDP-glucosyltransferase multigene family in Bombyx mori

BMC Genomics, 2008
Background Glucosidation plays a major role in the inactivation and excretion of a great variety of both endogenous and exogenous compounds. A class of UDP-glycosyltransferases (UGTs) is involved in this process.
Lu Cheng, Dai Fang-Yin, Liu Zeng-Hu, Zhang Ze, Chai Chun-Li, Huang Fei-Fei, Xiang Zhong-Huai   +6 more
doaj   +1 more source

Genome-wide characterization, evolution and expression profiling of UDP-glycosyltransferase family in pomelo (Citrus grandis) fruit

BMC Plant Biology, 2020
Background Pomelo is one of the three major species of citrus. The fruit accumulates a variety of abundant secondary metabolites that affect the flavor. UDP-glycosyltransferases (UGTs) are involved in the glycosylation of secondary metabolites.
Boping Wu, Xiaohong Liu, Kai Xu, Bo Zhang   +3 more
doaj   +1 more source

A simple model predicts UGT-mediated metabolism [PDF]

Bioinformatics, 2016
Abstract Motivation: Uridine diphosphate glucunosyltransferases (UGTs) metabolize 15% of FDA approved drugs. Lead optimization efforts benefit from knowing how candidate drugs are metabolized by UGTs. This paper describes a computational method for predicting sites of UGT-mediated metabolism on drug-like molecules. Results:
Na Le, Dang, Tyler B, Hughes, Varun, Krishnamurthy, S Joshua, Swamidass   +3 more
openaire   +2 more sources

Modifying Antibiotic Activity of Synthetic Thiadiazine Analogs Against MDR Bacteria and ADMET Analysis

ChemistryOpen, EarlyView.
The study demonstrated that thidiazine compounds potentiated the action of antibiotics. The compounds associated with norfloxacin against S. aureus showed greater significance in relation to the other medications. The indiscriminate use of antibiotics has led to the selection of resistant bacterial strains, significantly reducing the effectiveness of ...
João Arthur de Oliveira Borges, Priscilla Ramos Freitas, Isaac Moura Araújo, Ray Silva de Almeida, Igor José dos Santos Nascimento, João Xavier de Araújo‐Júnior, Edeildo Ferreira da Silva‐Júnior, Thiago Mendonça de Aquino, Francisco Jaime Bezerra Mendonça Junior, Emmanuel Silva Marinho, Hélcio Silva dos Santos, Radosław Kowalski, Grażyna Kowalska, Henrique Douglas Melo Coutinho, Saulo Relison Tintino, Ana Carolina Justino de Araújo   +15 more
wiley   +1 more source

Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.
Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen, Chaozhuang Shen, Yuchen Tian, Yuhe Peng, Jing Hu, Haitang Xie, Ping Yin   +6 more
wiley   +1 more source

INTRODUCTION OF AN N-GLYCOSYLATION SITE INTO UDP-GLUCURONOSYLTRANSFERASE 2B3 ALTERS ITS SENSITIVITY TO CYTOCHROME P450 3A1-DEPENDENT MODULATION

Frontiers in Pharmacology, 2016
Our previous studies have demonstrated functional protein-protein interactions between cytochrome P450 (CYP) 3A and UDP-glucuronosyltransferase (UGT). However, the role of carbohydrate chains of UGTs in the interaction with CYP is not well understood. To
Tatsuro Nakamura, Naho Yamaguchi, Yuu Miyauchi, Tomoki Takeda, Yasushi Yamazoe, Kiyoshi Nagata, Peter I Mackenzie, Hideyuki Yamada, Yuji Ishii   +8 more
doaj   +1 more source

Religious politics and the limits of redistribution: The rise and fall of family allowances in Spain, 1926–58

The Economic History Review, EarlyView.
Abstract After the Second World War, family allowances became a cornerstone of social spending in western Europe. Whilst religion is often highlighted as a driver of this policy, the role of political Catholicism remains contested, particularly in southern Europe.
Guillem Verd‐Llabrés
wiley   +1 more source

GeARF5/GeIAA33‐GeSWEET14 module balances the secondary metabolic biosynthesis to increase the yield and quality in Gastrodia elata

Journal of Integrative Plant Biology, EarlyView.
Auxin signaling regulates the formation of vegetative propagation corms in Gastrodia elata by regulating sugar‐acid interconversion, which in turn regulates polysaccharide and starch biosynthesis as well as biosynthesis of the bioactive metabolite gastrodin.
Qun Liu, Zhiqing Wu, Yugang Gao, Yue Xu, Pu Zang, Xinyu Yang, Yan Zhao, Pan Liao, Benoît Boachon, Guoyin Kai   +9 more
wiley   +1 more source

Bioconversion of carotenoids into high‐value crocins using a marine sponge carotenoid cleavage dioxygenase

New Phytologist, EarlyView.
Summary Carotenoids and apocarotenoids are widespread specialized metabolites, yet animals, including sponges, lack the ability to synthesize carotenoids de novo and must obtain them from dietary or microbial sources. The roles of carotenoid cleavage dioxygenases (CCDs) in marine animals remain largely unexplored. A CCD from the marine sponge Suberites
Elena Moreno‐Giménez, Lucía Morote, Alberto José López Jiménez, Eduardo Parreño, Jian You Wang, Matteo Nava, Carolina Aguado, Rafael Luján, Salim Al‐Babili, Gianfranco Diretto, Oussama Ahrazem, Lourdes Gómez‐Gómez   +11 more
wiley   +1 more source

Analisis Akuntansi Pembiayaan Mudarabah Berdasarkan PSAK 105 Pada BMT UGT Nusantara Cabang Pembantu Tayan

Aktiva
Purpose: This study aims to determine the management of mudarabah financing and to analyze the accounting treatment of mudarabah financing at BMT UGT Nusantara Tayan Sub-Branch based on PSAK 105.
Dini Lestary, Risatri Hayatunisa
doaj   +1 more source