Results 41 to 50 of about 21,310 (230)

Elementos de desarrollo territorial en la Provincia de Arauco

Urbano, 2005
La Región del Bío-Bío ha desarrollado con el fin de articular la inversión pública y hacerla más eficiente, una Estrategia Territorial, llamada Programa de Desarrollo Territorial (PDT), la que está en sintonía con las necesidades propias de cada ...
Ximena Oliva Aravena
doaj  

Integrated assessment of rifampicin‐mediated induction of transporters and drug‐metabolizing enzymes in a long‐term human liver tissue chip system

Clinical Pharmacology &Therapeutics, EarlyView.
Rifampicin is a prototypical clinical inducer used in drug–drug interaction (DDI) studies. However, the clinical relevance and predictability of rifampicin‐mediated hepatic transporter induction remain poorly defined. Conventional hepatocyte culture models fail to capture clinically relevant regulation of transporters and drug‐metabolizing enzymes ...
Mattie E. Hartauer, Raeanne M. Lanphier, Shivam Ohri, Jessica Snyder, Jacqueline B. Tiley, John K. Fallon, Henry Ho, Murat Cirit, Shiny Amala Priya Rajan, Kim L. R. Brouwer   +9 more
wiley   +1 more source

The UDP-glucosyltransferase multigene family in Bombyx mori

BMC Genomics, 2008
Background Glucosidation plays a major role in the inactivation and excretion of a great variety of both endogenous and exogenous compounds. A class of UDP-glycosyltransferases (UGTs) is involved in this process.
Lu Cheng, Dai Fang-Yin, Liu Zeng-Hu, Zhang Ze, Chai Chun-Li, Huang Fei-Fei, Xiang Zhong-Huai   +6 more
doaj   +1 more source

Genome-wide analysis of UGT gene family identified key gene for the biosynthesis of bioactive flavonol glycosides in Epimedium pubescens Maxim.

Synthetic and Systems Biotechnology, 2022
Epimedium pubescens Maxim. is a well-known traditional Chinese medicinal herb with flavonol glycosides as the major pharmaceutically active compounds. UDP-glycosyltransferases (UGTs) are a group of enzymes responsible for the glycosylation of flavonoid ...
Yu Yao, Jiajun Gu, Yanjiao Luo, Yuanyue Wang, Yongzhen Pang, Guoan Shen, Baolin Guo   +6 more
doaj   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Genome-wide characterization, evolution and expression profiling of UDP-glycosyltransferase family in pomelo (Citrus grandis) fruit

BMC Plant Biology, 2020
Background Pomelo is one of the three major species of citrus. The fruit accumulates a variety of abundant secondary metabolites that affect the flavor. UDP-glycosyltransferases (UGTs) are involved in the glycosylation of secondary metabolites.
Boping Wu, Xiaohong Liu, Kai Xu, Bo Zhang   +3 more
doaj   +1 more source

Biomechanical Analysis of Unplanned Gait Termination According to a Stop-Signal Task Performance: A Preliminary Study

Brain Sciences, 2023
There is a correlation between cognitive inhibition and compensatory balance response; however, the correlation between response inhibition and gait termination is not clear. Objectives: The purpose of this study was to investigate the gait parameters of
Dong-Kyun Koo, Jung-Won Kwon
doaj   +1 more source

The effect of antiseizure medications on the exposure to combined oral contraceptives: A systematic review and network meta‐analysis

Epileptic Disorders, EarlyView.
Abstract Objective Current recommendations for prescribing combined oral contraceptives (COCs) to people with epilepsy are often conflicting, particularly for weak inducers of cytochrome P450 3A4. We aimed to critically review the literature and compare the antiseizure medication (ASM)‐induced changes in exposure to COC components.
Hagar Cohen, Amnah Omar Mahajna, Tomer Ben‐Shushan, Ilan Matok, Sara Eyal   +4 more
wiley   +1 more source

Substrate Specificity of Opioid Compounds to UDP-Glucuronosyltransferase (UGT), hUGT2B7 and Bovine Microsomal UGT

Journal of Health Science, 2005
We studied the substrate specificity of some opioid derivatives of 5,9-dimethyl-2′-hydroxybenzomorphan [1], composed of A, B, and D ring-systems of morphine, for human UDP-glucuronosyltransferase 2B7 (hUGT2B7), a typical glucuronidation enzyme to morphine and for bovine microsomal UGT.
Iwamura, Tatsunori, Ito, Yuko, Kuno, Nayumi, Mizutani, Takaharu   +3 more
openaire   +2 more sources

Computational analysis of variation in C. elegans ugts

microPublication biology, 2023
Caenorhabditis elegans are free-living nematodes with a relatively short life cycle and a wealth of genomic information across multiple databases. Uridine diphosphate-glycosyltransferases (UGTs) are a family of enzymes involved in Phase II modification of xenobiotics in C.
Asif, Muhammad Zaka, Benveniste, Maci C., Chism, Kyra D., Levin, Ari L., Lanier, Deanna, Watkins, Rockford E., Taujale, Rahil, Tucker, Niyelle, Edison, Arthur S.   +8 more
openaire   +2 more sources