Results 51 to 60 of about 12,805 (208)
Rewiring Steroidal Metabolic Pathways for Diosgenin Production in Solanum nigrum
ABSTRACT Diosgenin is a key starting material for the synthesis of steroidal drugs, such as corticosteroids and sex hormones. While the primary commercial source of diosgenin is the tubers of Dioscorea spp., identifying alternative plant hosts capable of diosgenin biosynthesis could enhance its production.
Jongbu Lim +16 more
wiley +1 more source
In silico prediction of UGT-mediated metabolism in drug-like molecules via graph neural network
UDP-glucuronosyltransferases (UGTs) have gained increasing attention as they play important roles in the phase II metabolism of drugs. Due to the time-consuming process and high cost of experimental approaches to identify the metabolic fate of UGT ...
Mengting Huang +6 more
doaj +1 more source
ABSTRACT Gynostemma pentaphyllum, a herb used in tea and traditional Chinese medicine, shows geographic variation in its production of valuable dammarane‐type ginsenosides and gypenoside LVI between populations from Suining (SN) and Nanning (NN). To elucidate the mechanisms underlying this differential metabolite accumulation, a chromosome‐level genome
Peina Zhou +12 more
wiley +1 more source
Multi‐Omics Insights Into Anthraquinone Biosynthesis in Rheum tanguticum
ABSTRACT Rheum tanguticum is renowned for its medicinal properties, including purgative, anti‐inflammatory and hepatoprotective effects, primarily attributed to anthraquinones (AQs). However, the molecular mechanisms of AQs biosynthesis have largely been hindered by insufficient genomic resources and functional genomics investigations.
Shuo Zhao +6 more
wiley +1 more source
PSOE and UGT after the legislative elections of 1933
After losing the elections and its parliamentary group reduced fifthy per cent, the executive committee of the Partido Socialista Obrero Español wanted to put into practice what its president, Francisco Largo Caballero, had announced and proclaimed ...
Víctor Manuel Arbeloa
doaj
ABSTRACT Belamcanda chinensis is a non‐leguminous medicinal plant rich in bioactive isoflavones; however, the lack of a high‐quality reference genome has limited elucidation of its isoflavone biosynthetic and modification network. Here, we present the first near telomere‐to‐telomere genome assembly of B.
Yuan‐Yuan Wang +10 more
wiley +1 more source
Creation of bioactive non‐natural flavonoids via combinatorial prenylation–glycosylation cascades
mLife, EarlyView.
Hongjiao Zhang +3 more
wiley +1 more source
Sap flow and reversible stem shrinkage upon water depletion are strongly correlated under extreme drought conditions, but they respond differently to drought and cannot be used interchangeably when assessing tree response to drought. Abstract Temperate mixed forests are currently experiencing severe drought conditions and face increased risk of ...
L. S. Donfack +6 more
wiley +1 more source
Gap Analysis of Metabolic Conversions of Off‐Flavors and Antinutrients in Plant‐Based Substrates
ABSTRACT To drastically reduce the carbon footprint of the food production chain, a major shift towards alternatives to conventional meat and dairy products is required. The use of plant‐based proteins is a promising route, but it also comes with challenges: Plant‐based proteins often contain antinutritional factors and off‐flavors, which can ...
Robin I. Kuijpers +16 more
wiley +1 more source

