Results 201 to 210 of about 17,886 (241)

Comparative Pharmacokinetics of Intranasal or Intramuscular Atipamezole in Unsedated Dogs and Efficacy for Reversal of Xylazine Sedation

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT The objectives of this study were to evaluate ATIP pharmacokinetics (PK) in healthy Beagle dogs after IM and IN dosing (Phase I), and to compare the rate of reversal of IM versus IN routes for xylazine (XYL) sedation (Phase II). This study was comprised of two sequential, randomized, crossover experiments. The initial PK study dosed ATIP by IN
Vanessa E. Cowan, Vanessa R. Mitcham, Deborah L. Michel, Chloe Lyons, Juliet Kennedy, Yoana C. Reyes Morales, Jennifer M. Loewen, Alan L. Chicoine   +7 more
wiley   +1 more source

The Pharmacokinetics of Intravenous and Subcutaneous Ondansetron in Female Beagle Dogs

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT The purpose of this study was to evaluate the pharmacokinetic profile of ondansetron following intravenous (IV) and subcutaneous (SC) administration in five healthy adult female Beagles. Dogs were administered ondansetron at 0.5 mg/kg IV and SC in a randomized crossover design.
Elena D. Landau, Kendal R. Boege, Kristen Messenger, Gregory Ballash, Daniel Gustafson, Carolina Ricco Pereira, Krista Banks, Turi Aarnes, Phillip Lerche, Monica Midon, Kirk A. Muñoz   +10 more
wiley   +1 more source

Pharmacokinetics of Intramuscular and Intravenous Glycopyrrolate in Juvenile New Zealand White Rabbits

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Glycopyrrolate is an alternative to atropine to treat bradyarrhythmias in anesthetized rabbits; however, there are no pharmacokinetic studies in the literature. Six female New Zealand White rabbits received glycopyrrolate 0.05 mg/kg intravenously (IV) in the cephalic vein or intramuscularly (IM) in a complete crossover design.
Jocelyn Marchiori, Andrea Sanchez, Kristen Messenger, Jennifer M. Reinhart, Hugues Beaufrère, Sonja Fonfara, Alexander Valverde, Yu Gu, Ron Johnson   +8 more
wiley   +1 more source

A multi-mycotoxin UHPLC-MS/MS method for the detection, quantification and identification of mycotoxins in milk replacer [PDF]

, 2014
Antonissen, Gunther, Croubels, Siska, Daeseleire, Els, De Saeger, Sarah, Valgaeren, Bonnie, Van Pamel, Els   +5 more
core   +1 more source

Non‐innocent solvents in meteorite extractions: Evidence for artifact formation

Meteoritics &Planetary Science, EarlyView.
Abstract Solvent extraction is a cornerstone of meteoritic organic and inorganic chemistry, yet the assumption that common solvents act as chemically inert media is becoming increasingly untenable. This study reports that low‐molecular‐weight alcohols, particularly methanol and ethanol, are “non‐innocent” solvents when used to extract soluble sulfur ...
N. Randazzo, R. W. Hilts, R. M. Whittal, B. Reiz, V. Olan‐Rubio, C. D. K. Herd, I. H. Krouse   +6 more
wiley   +1 more source

Saccharomyces cerevisiae Yeast‐Based Supplement and Breast Milk Supply: A Randomised Placebo‐Controlled Trial

Maternal &Child Nutrition, EarlyView.
Maternal brewer's yeast supplementation did not change the milk oligosaccharide (HMO) concentration, but more mothers felt their milk supply was increased, and fewer reported formula use by 6 months postpartum compared to those taking the placebo. This suggests the supplement may support breastfeeding, warranting further investigation in larger trials.
Lili Jia, Louise Brough, Janet L. Weber
wiley   +1 more source

Equipped for success: genomes and metabolomes of the European Amanita muscaria are conserved in its novel South African range

New Phytologist, EarlyView.
Summary Plants and soils have been moved around the world for centuries, but invasive mushrooms receive scant attention. The Amanita muscaria species complex was introduced to South Africa in the context of forestry, but its origins, ecology and recent evolution are unstudied. We sequenced the genomes of 24 Northern and Southern Hemisphere A. muscaria,
Grant R. Nickles, Cecelia K. Stokes, Deborah L. Narh, Kira M. T. Lynn, Savannah R. Fuqua, Corbin Bryan, Brooke M. Allen, Christopher P. Bivins, Jin Woo Bok, J. Stephen Brewer, Sikelela T. Buthelezi, Jahiya P. R. M. Clark, Kerri L. Coon, Lauren R. Corby, Martin P. A. Coetzee, Claudette Dewing, Tuan A. Duong, Mathew A. Harris, Nancy P. Keller, Katlego Kopotsa, Frances A. Lane, Holly L. Nichols, Alandie Nieuwoudt, Martin A. Nuñez, Miguel E. Medina Munoz, Sung Chul Park, Nam Q. Pham, Kaetlyn T. Ryan, Myriam Solís, Rytas Vilgalys, Jasmine Marea Wallace, Yen‐Wen Wang, Brenda D. Wingfield, Michael J. Wingfield, Travis K. Worley, Taylor A. Zallek, Mostafa Zamanian, Jason D. Hoeksema, Milton T. Drott, Anne Pringle   +39 more
wiley   +1 more source

Benzoxazinoid‐mediated microbiome feedbacks enhance Arabidopsis growth and defence

New Phytologist, EarlyView.
Summary Plants modulate their surrounding microbiome via root exudates and such conditioned soil microbiomes feed back on the performance of the next generation of plants. How plants perceive altered soil microbiomes and modulate their performance in response to such microbiome feedbacks, however, remains largely unknown.
Katja Stengele, Lea Stauber, Lisa Thoenen, Henry Janse van Rensburg, Viola D'Adda, Klaus Schlaeppi   +5 more
wiley   +1 more source

A Chemical Probe for Increasing Leaf Tocopherol Levels by Coordinated Modulation of Biosynthesis, Competition and Storage

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant biofortification with phytonutrients typically relies on metabolic engineering strategies known as ‘push’ (enhancing biosynthetic flux), ‘block’ (inhibiting competing pathways) and ‘pull’ (promoting metabolite storage). Here, we describe a novel synthetic compound, X57, that simultaneously targets biosynthesis, competition and storage to
Pablo Perez‐Colao, Gaetan Glauser, Jacobo Cruces, Jorge Lozano‐Juste, Manuel Rodriguez‐Concepcion   +4 more
wiley   +1 more source

Expression of a Bacterial Trehalose 6‐Phosphate Synthase Gene otsA in Camelina sativa Seeds Promotes the Channelling of Carbon Towards Oil Accumulation

Plant Biotechnology Journal, EarlyView.
ABSTRACT Improving seed oil yield is essential for developing Camelina sativa as a sustainable biofuel crop. Fatty acid synthesis depends on the production of acetyl‐CoA from photosynthetically derived sugars. Trehalose 6‐phosphate (T6P), a proxy for sucrose availability, can link sugar status to plant growth and development. Synthesised by trehalose 6‐
Saroj Kumar Sah, Zhiyang Zhai, Hai Shi, Jin Chai, Elen Deng, Jorg Schwender, Xiao‐Hong Yu, John Shanklin   +7 more
wiley   +1 more source