Results 221 to 230 of about 61,869 (301)

Opposing roles of DGAT‐mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity

The FEBS Journal, EarlyView.
Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump, Leja Perne, Špela Koren, Eva Jarc Jovičić, Nastja Feguš, Carina Pinto Kozmus, Michele Wölk, Kristyna Brejchova, Maria Fedorova, Ondrej Kuda, Toni Petan   +10 more
wiley   +1 more source

Machine Learning and UHPLC-MS/MS-Based Discrimination of the Geographical Origin of <i>Dendrobium officinale</i> from Yunnan, China. [PDF]

Foods
Lin T, Ye Y, Zhang J, Wang J, Hu Z, Linn KZ, Chen X, Liu H, Liu Z, Yao Q.   +9 more
europepmc   +1 more source

A new branch of mammalian vitamin B6 metabolism: AKR1C‐mediated conversion of pyridoxal to pyridoxine and 4‐pyridoxolactone

The FEBS Journal, EarlyView.
Pyridoxal 5′‐phosphate (PLP) homeostasis relies on salvage enzymes, yet key metabolic branches remain undefined. We identify AKR1C isozymes as previously undescribed contributors that convert pyridoxal into pyridoxine or 4‐pyridoxolactone through reductase and dehydrogenase activities.
Nayu Kito, Yasuyuki Kitaura, Kyoka Iino, Kazuya Toriumi, Hyunah Noh, Naoya Ogawa, Makoto Arai, Hisashi Hemmi, Tomokazu Ito   +8 more
wiley   +1 more source

Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry

The FEBS Journal, EarlyView.
Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero, Juan Luis Pacheco‐Garcia, Pavla Vankova, Dmitry Loginov, Isabel Quereda‐Moraleda, Jose Manuel Martin‐Garcia, Petr Man, Angel Luis Pey, Milagros Medina   +8 more
wiley   +1 more source

Development of a UHPLC-MS/MS Method for Quantitative Analysis of Aflatoxin B₁ in <i>Scutellaria baicalensis</i>. [PDF]

Toxins (Basel)
Liu Y, Zeng C, Li YY, Guo J, Xu J.
europepmc   +1 more source

Lethal Effects of the Wild Potato Solanum bulbocastanum on the Planthopper Pentastiridius leporinus, a Vector of Bacterial Pathogens in Potato

Journal of Applied Entomology, EarlyView.
ABSTRACT The planthopper Pentastiridius leporinus [Hemiptera: Cixiidae] is a vector of the two plant pathogenic bacteria ‘Candidatus Arsenophonus phytopathogenicus’ and ‘Candidatus Phytoplasma solani’ causing ‘bacterial potato tuber wilt’ in potato.
Eva Therhaag, Karin Gorzolka, Jürgen Gross   +2 more
wiley   +1 more source

Development of a UHPLC-MS method to avoid the in-source dissociation interference in characterization of crocins from Buddlejae flos and its dyeing yellow rice. [PDF]

Front Plant Sci
Cheng S, Mi J, Jiang S, Li A, Zhong Z, Chen Z.   +5 more
europepmc   +1 more source

Association of Fontan Circulation With Gut Microbiome Derived Straight and Branched Short Chain Fatty Acids

Journal of Gastroenterology and Hepatology, EarlyView.
Adults with Fontan circulation (n = 20) and matched controls underwent body composition, frailty testing, CPET, and NICaS hemodynamics. Plasma short‐chain fatty acids were quantified by LC–MS/MS. Fontan patients had higher straight and branched SCFAs, correlating with lower muscle mass, greater frailty, reduced VO2max, and worse resting/postexercise ...
Ashish H. Shah, Yixiu Liu, Heather K. Armstrong, Jun Han, David R. Goodlett, Amir Ravandi, Sanjiv Dhingra   +6 more
wiley   +1 more source

RP-UHPLC/MS/MS Provides Enhanced Lipidomic Profiling of Human Serum in Pancreatic Cancer

Lásko Z, Peterka O, Jirásko R, Taylor A, Hájek T, Mohelníková-Duchoňová B, Loveček M, Melichar B, Holčapek M.   +8 more
europepmc   +1 more source

Simultaneous Quantification of Multiple Analytes in Rat Plasma by UHPLC-MS/MS Following Oral Administration of <i>Gastrodiae Rhizoma</i> Extract for Pharmacokinetic Evaluation. [PDF]

Molecules
Chen L, Zhu Y, Ouyang H, Wu X, Lin W, Zhang K, He J.   +6 more
europepmc   +1 more source