Results 41 to 50 of about 17,886 (241)

Chemical genetics uncovers novel inhibitors of lignification, including p-iodobenzoic acid targeting CINNAMATE-4-HYDROXYLASE [PDF]

, 2016
Plant secondary-thickened cell walls are characterized by the presence of lignin, a recalcitrant and hydrophobic polymer that provides mechanical strength and ensures long-distance water transport.
Audenaert, Dominique, Boerjan, Wout, Decou, Raphael, Goeminne, Geert, Höfer, René, Nguyen, Long, Pesquet, Edouard, Van de Wouwer, Dorien, Vanholme, Bartel, Vanholme, Ruben   +9 more
core   +2 more sources

COSY catalyses trans-cis isomerization and lactonization in the biosynthesis of coumarins [PDF]

, 2019
Coumarins, also known as 1,2-benzopyrones, comprise a large class of secondary metabolites that are ubiquitously found throughout the plant kingdom.
Boerjan, Wout, De Meester, Barbara, Goeminne, Geert, Haustraete, Jurgen, Hoengenaert, Lennart, Kim, Hoon, Li, Jin, Liu, Xinyu, Morreel, Kris, Ralph, John, Schmidt, Wolfgang, Seetso, Carol, Sundin, Lisa, Tsai, Huei-Hsuan, Vanholme, Bartel, Vanholme, Ruben   +15 more
core   +1 more source

Non-targeted LC-MS based metabolomics analysis of the urinary steroidal profile [PDF]

, 2017
The urinary steroidal fraction has been extensively explored as non-invasive alternative to monitor pathological conditions as well as to unveil the illicit intake of pseudo-endogenous anabolic steroids in sport.
Botrè, Francesco, de la Torre, Xavier, Palermo, Amelia, Zamboni, Nicola   +3 more
core   +1 more source

A Rapid Method for the Determination of Potassium Iodide in Ophthalmic Formulations by Indirect Derivatization with 4-Hydroxybenzoic Acid Using UHPLC–DAD and MS/MS Detection

Applied Sciences
A rapid ultra-high-performance liquid chromatography method with diode-array (DAD) and tandem mass spectrometric (MS/MS) detection was developed and, for the first time, applied for the determination of potassium iodide in ophthalmic formulations.
Jordan Sycz, Anna Duda-Madej, Antoni Szumny   +2 more
doaj   +1 more source

Differences in the metabolite composition and mechanical properties of extracellular vesicles secreted by hepatic cellular models

Journal of Extracellular Vesicles, 2019
Liver constitutes the major metabolic factory in the organism and is involved in the synthesis, secretion and clearance of many blood-circulating molecules.
Felix Royo, David Gil-Carton, Esperanza Gonzalez, Justyna Mleczko, Laura Palomo, Miriam Perez-Cormenzana, Rebeca Mayo, Cristina Alonso, Juan M. Falcon-Perez   +8 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

The effect of Rosmarinus officinalis L infusion supplementation on blood pressure among healthy volunteers and grade 1 hypertensive patients

Phytomedicine Plus
Background: Rosmarinus officinalis L, has been traditionally used to manage various ailments. Preclinical trials have reported the antihypertensive effect of the bioactive compounds in rosemary.
Awatef Sassi, Aicha Laouani, Mohamed Aymen Ben Abdessalem, Imen Jarray, Hana Nasrallah, Farhana Ferdousi, Manel Nouira, Ali Mtiraoui, Abdallah Mahdhaoui, Hiroko Isoda, Saad Saguem   +10 more
doaj   +1 more source

A New Strategy for Efficient Retrospective Data Analyses for Designer Benzodiazepines in Large LC-HRMS Datasets

Frontiers in Chemistry, 2022
The expanding and dynamic market of new psychoactive substances (NPSs) poses challenges for laboratories worldwide. The retrospective data analysis (RDA) of previously analyzed samples for new targets can be used to investigate analytes missed in the ...
Meiru Pan, Brian Schou Rasmussen, Petur Weihe Dalsgaard, Christian Brinch Mollerup, Marie Katrine Klose Nielsen, Michael Nedahl, Kristian Linnet, Marie Mardal, Marie Mardal   +8 more
doaj   +1 more source

A single meal has the potential to alter brain oxylipin content. [PDF]

, 2020
Our objective was to determine whether consumption of a single meal has the potential to alter brain oxylipin content. We examined the cerebrum of mice fed a single high-fat/high-sucrose Western meal or a low-fat/low-sucrose control meal, as well as ...
Aung, HH, Norman, JE, Otoki, Y, Rutledge, JC, Taha, AY, Zhang, Z   +5 more
core   +1 more source