Results 151 to 160 of about 67,993 (297)
Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress
Advanced Science, EarlyView.Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen +11 more
wiley +1 more source
Advanced Science, EarlyView.This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu +7 more
wiley +1 more source
Angewandte Chemie, EarlyView.The carbocyclic Decitabine analog (cAzadC) incorporates as an antimetabolite weakly into the genome of growing tumor cells, where it triggers a genome‐wide demethylation and a surprisingly strong hydroxymethylation of cytosine, which translates into an efficient in vivo antitumor (AML) effect.
Maike Däther +17 more
wiley +2 more sources
Secrets in the Snow: Nontargeted Analysis of CECs in Mountain Environments Using UHPLC-HRMS [PDF]
This work is part of the IN2AQUAS project, financed within the EU Horizon program, which aims to secure water quality from remote regions to the tropical belt.
Manuel A. A. Enríquez +7 more
core
Advanced Science, EarlyView.A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker +11 more
wiley +1 more source
Advanced Science, EarlyView.We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen +5 more
wiley +1 more source
海洋浮游植物色素UHPLC-MS/MS检测及应用研究 [PDF]
, 2017 浮游植物是海洋生态系统中最主要的初级生产力，其群落结构及其丰度不仅能够影响上层海洋食物网和生物地球化学循环过程，而且还能够影响气候变化，减轻温室效应带来的不利影响。浮游植物色素是指示其群落结构变化的重要指标，因此，准确检测浮游植物色素是海洋生态技术研究的重要内容。目前，常用的高效液相色谱（HPLC）色素检测方法具有一定的局限性，存在灵敏度与准确度较低的缺点。本研究针对该问题，开发了两种灵敏度高、准确度高的超高效液相色谱串联质谱（UHPLC-MS/MS）方法，可以同时检测多种浮游植物色素 ...
张晶晶
core
Animal Models and Experimental Medicine, EarlyView.The research strategy for pharmacodynamics, serum pharmacochemistry, metabolomics, and network pharmacology analysis method in intervention effects of LTT are illustrated. Abstract Background Liujing Toutong tablet (LTT) is a traditional Chinese patent medicine.
Zihan Yu +10 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.Gut microbiota from patients with type 2 diabetes induced early diabetes‐like phenotypes in germ‐free mice, including progressive glucose intolerance and mild renal injury. Longitudinal profiling revealed persistent dysbiosis preceding stable metabolic dysfunction, with coordinated fecal and plasma metabolite alterations and a prominent L‐Dopa ...
Jianghao Feng +6 more
wiley +1 more source