Results 131 to 140 of about 67,993 (297)

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

A Rapid Method for the Determination of Potassium Iodide in Ophthalmic Formulations by Indirect Derivatization with 4-Hydroxybenzoic Acid Using UHPLC–DAD and MS/MS Detection

Applied Sciences
A rapid ultra-high-performance liquid chromatography method with diode-array (DAD) and tandem mass spectrometric (MS/MS) detection was developed and, for the first time, applied for the determination of potassium iodide in ophthalmic formulations.
Jordan Sycz, Anna Duda-Madej, Antoni Szumny   +2 more
doaj   +1 more source

Fast protein digestion and identification using hybrid silica monolith based metal-ion chelately immobilized trypsin microreactor and uHPLC-MS/MS [PDF]

, 2008
Fast protein digestion and identification are indispensable in mosr proteomic study.Immobilized enzyme microreactors,especially those based on monoliths, recently have been paid much attention due to the fast digestion speed and the avoidance of enzyme ...
马俊锋, 梁振, 张玉奎, 张维冰, 张丽华   +4 more
core  

Efficient Concentration and Complete Destruction of Short‐Chain and Emerging PFAS in Contaminated Water via Integrated Interface Engineering‐Enhanced Carbon Felt Sorption and Photochemical Processes

Advanced Science, EarlyView.
A closed‐loop “Concentrate‐Destroy” strategy is presented for completely eliminating short‐chain and emerging PFAS, in which the new 3D PPy@P‐CF is used for efficiently concentrating PFAS and Cu2+‐mediated photodegradation is applied for the completely destroying PFAS in the sorbent regeneration eluent.
Hao Yu, Jialei Guo, Peng Zhang, Hongyi Li, Feng He, Hongwen Sun   +5 more
wiley   +1 more source

Development of an analytical method for the quantification of isoflavones in legumes by SPE-UHPLC-MS/MS [PDF]

, 2013
Legumes include lentils, beans, chickpeas, fava beans, soy beans and others. Cultivated for thousands of years, they have played an important role in the traditional diets of many regions throughout the world. A new method, that consists of an extraction
Gianni Sagratini, Sauro Vittori, Pilar Vila Donat, Massimo Ricciutelli, Filippo Maggi, Elisabetta Torregiani, Giovanni Caprioli, Manuela Cortese   +7 more
core  

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Development of Validated RP-UHPLC and Analogous UV Spectroscopic Methods for the Analysis of Tofacitinib Citrate

Drug Analytical Research
The current study aims to develop and optimize a simple, novel, reproducible and efficient RP-UHPLC and its analogous UV spectroscopic method for routine analysis of Tofacitinib Citrate (TFC).
Md. Jahid Hossain, Diponkor Kumar Shill, Kausik Chandra Mondal, Abu Shara Shamsur Rouf, Uttom Kumar   +4 more
doaj   +3 more sources

Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae

Advanced Science, EarlyView.
We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang, Mengmeng Li, Xuehui Dai, Yanchen Zhang, Yuhan Wu, Zhaotao Yan, Chenfei Tian, Hongkai Fan, Haili Liu, Xiaowei Zhang, Yiming Yang, Jiayu Lu, Yuwei Sun, Yong Wang   +13 more
wiley   +1 more source

Unveiling the global landscape of anabolic steroid residues in beef via integrated targeted quantification and high-resolution suspect screening

Current Research in Food Science
Anabolic steroid (AS) residues in animal-derived foods continues to pose a significant concern due to their potential risks to food safety and human health.
Huijing Shen, Xuanyu Wu, Xinyu Ge, Chi Zhang, Rong Liu, Shuang Zhou, Yongning Wu   +6 more
doaj   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source